Epidemiological evaluation focusing on prognostic impact of young age in Egyptian patients with colorectal Cancer, NEMROCK experience

Abstract

Worldwide, Colorectal cancer (CRC) is the most common malignant tumor of the gastrointestinal tract. It is the third most common cancer after lung and breast cancers and the second most common cause of death in both genders 1,2. CRC is a disease affecting mainly older persons, more than 90% of patients being diagnosed after the age of 55 years 3. However, epidemiologic features of CRC vary widely in different parts of the world 4. Epidemiological studies of CRC in Egypt showed that patients younger than 40 years represented a significant percentage and constituted 30% to 40% of all cases, which is the highest incidence documented in this age group for colorectal cancer patients worldwide 5-7. In young patients, colorectal cancer tends to present more commonly with stage III or IV disease. Conflicting results about prognosis of younger patients are published, some studies proved bad prognosis and some reported to be the same like older patients 7-9. Since data regarding prognosis of young patients with CRC in Egypt is limited, we decided to describe the epidemiological characteristics of colorectal cancer patients in Egypt and to focus on the prognosis of young patients. Data was taken from Kasr Al Ainy Center of Clinical Oncology and Radiation Therapy (NEMROCK) at Cairo University.

Expression of long non coding RNA H19& miR-675 in colorectal cancer and ulcerative colitis patients

“…In our study, demographic data which comprises age and gender showed a signi cant difference regarding age where CRC group showed a higher mean of age with statistical signi cance when compared to both control and UC groups who showed a lower mean in their ages, this comes in accordance with other studies [3,23,24] which stated that colorectal cancer is mainly a disease of the elderly [23]or above the age of 55 [24,10]. These results were previously challenged in an Egyptian study [25] that recognized a relatively high percentage of patients diagnosed with CRC at a younger age group (between 20-40 years).…”