Epidemiological characteristics of patellofemoral osteoarthritis in elderly Koreans and its symptomatic contribution in knee osteoarthritis

Cho, Hyung Joon; Gn, Kiran Kumar; Kang, Jung Mook; Suh, Kuen Tak; Kim, Tae Kyun

doi:10.1016/j.knee.2015.09.003

Cited by 19 publications

(14 citation statements)

References 36 publications

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“…The prevalence of any PF OA in community-based population was 32% (24 to 42) in those aged 50 years or over from eight studies 19 24 26 28 39 46 54 75. Only one study described prevalence of isolated compartment-specific PF OA,26 with prevalence of medial PF OA at 0.3% in women and 0.7% in men, and the prevalence of lateral PF OA at 1.6% in women and 3.7% in men. Sensitivity analyses based on sex revealed that the prevalence of any PF OA in women was 41% (31 to 51) from six studies18 19 24 26 28 75 and 47% (23 to 71) in men from four studies 18 19 24 26…”

Section: Resultsmentioning

confidence: 99%

The prevalence of radiographic and MRI-defined patellofemoral osteoarthritis and structural pathology: a systematic review and meta-analysis

et al. 2017

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BackgroundPatellofemoral osteoarthritis (PF OA) is more prevalent than previously thought and contributes to patient’s suffering from knee OA. Synthesis of prevalence data can provide estimates of the burden of PF OA.ObjectiveThis study aims to conduct a systematic review and meta-analysis on the prevalence of PF OA and structural damage based on radiography and MRI studies in different populations.MethodsWe searched six electronic databases and reference lists of relevant cross-sectional and observational studies reporting the prevalence of PF OA. Two independent reviewers appraised methodological quality. Where possible, data were pooled using the following categories: radiography and MRI studies.ResultsEighty-five studies that reported the prevalence of patellofemoral OA and structural damage were included in this systematic review. Meta-analysis revealed a high prevalence of radiographic PF OA in knee pain or symptomatic knee OA (43%), radiographic knee OA or at risk of developing OA (48%) and radiographic and symptomatic knee OA (57%) cohorts. The MRI-defined structural PF damage in knee pain or symptomatic population was 32% and 52% based on bone marrow lesion and cartilage defect, respectively.ConclusionOne half of people with knee pain or radiographic OA have patellofemoral involvement. Prevalence of MRI findings was high in symptomatic and asymptomatic population. These pooled data and the variability found can provide evidence for future research addressing risk factors and treatments for PF OA.Trial registration numberPROSPERO systematic review protocol (CRD42016035649).

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Section: Resultsmentioning

confidence: 99%

The prevalence of radiographic and MRI-defined patellofemoral osteoarthritis and structural pathology: a systematic review and meta-analysis

et al. 2017

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“…This is relevant for our study, which was carried out later in the life course, as increased age may explain the increased prevalence of patellofemoral disease. Prior studies have used WOMAC [ 10 , 18 ], reported symptoms [ 9 ] and pain [ 19 ] in the context of OA of the compartments of the knee. We found a significant association between WOMAC knee symptoms (including pain on stair climbing), clinical signs and tibiofemoral OA, but no significant associations with patellofemoral OA following adjustment.…”

Section: Discussionmentioning

confidence: 99%

“…The patellofemoral joint is associated with pain when walking up and down stairs [ 6 , 7 ] and can be managed by conservative therapy such as quadriceps strengthening exercises, and rarely, surgical treatment such as patellofemoral arthroplasty. Epidemiological studies highlight that patellofemoral OA [ 8 , 9 ] can occur in consort with tibiofemoral OA or in isolation, with some studies finding a significant difference in the demography of the two conditions [ 10 ]. There is a growing body of evidence to suggest that patellofemoral knee OA impacts independently on function and symptoms, and therefore, the aetiology and risk factors for tibiofemoral and patellofemoral knee OA may differ [ 7 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, changes in symptoms and, more particularly, in structure over 3 years in patients with osteoarthritis have been shown to reflect a clinically relevant progression of the disease [ 17 ]. Previous studies have investigated clinical correlation of knee symptoms in patellofemoral disease using WOMAC [ 10 , 18 ], reported symptoms [ 9 ] and pain [ 19 ], but these have not included physical, knee examination in their assessments. Other studies have focused on examining the prevalence of patellofemoral OA in specific ‘knee pain’ groups.…”

Section: Introductionmentioning

confidence: 99%

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Concordance between clinical and radiographic evaluations of knee osteoarthritis

et al. 2017

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BackgroundSignificant correlation has been previously demonstrated between radiographic and clinical diagnoses of knee osteoarthritis (OA); however, the specific findings on clinical examination that relate best to a radiographic diagnosis have not been fully elicited.AimsWe aimed to explore the relationship between clinical symptoms and physical findings with radiographic diagnoses of tibiofemoral and patellofemoral OA.MethodsThis study was based on 409 individuals from the Hertfordshire Cohort Study, born between 1931 and 1939. Antero-posterior and lateral radiographs were taken of both knees. The presence of tibiofemoral and patellofemoral OA was defined according to the Kellgren and Lawrence score. Clinical symptoms, assessed using WOMAC, and physical findings were ascertained by examination. Relationships were assessed using multilevel univariate logistic regression.ResultsIn the 775 knees studied, the prevalence of physical findings was crepitus (25%), tibiofemoral tenderness (15%), bony swelling (12%), and pain on flexion (10%). Thirty-one percent (n = 238) knees demonstrated tibiofemoral OA, 28% (n = 220) showed patellofemoral OA, and 16% demonstrated OA in both locations. A global clinical symptom score was associated with increased risk of tibiofemoral OA (OR 12.5, 95% CI 5.4–29.0) and patellofemoral OA (OR 5.1, 95% CI 2.3–13.1). On clinical examination, the presence of crepitus, tibiofemoral tenderness, bony swelling, and pain on flexion was associated with increased risk of tibiofemoral OA; however, only tenderness was found to be associated with patellofemoral OA.ConclusionGlobal clinical symptom score was associated with radiographic tibiofemoral and patellofemoral OA. However, individual clinical signs were more strongly associated with tibiofemoral than patellofemoral OA.

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“…Osteoarthritis (OA) is one of the most common diseases affecting older people[1,2]. Non-surgical treatments are usually first line management of OA-associated knee degeneration[3], but there are no targeted drugs to combat OA because of its elusive pathogenic mechanism[4] and research into novel pharmacological interventions remains critical[5].…”

Section: Introductionmentioning

confidence: 99%

T140 blocks the SDF-1/CXCR4 signaling pathway and prevents cartilage degeneration in an osteoarthritis disease model

et al. 2017

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Osteoarthritis (OA) is one of the most common diseases affecting older people; however, there remains no effective targeted drug to combat OA. The aims of this study were (1) to explore the effect of T140 in regulating degeneration of articular cartilage in vivo by targeted blocking of the SDF-1/CXCR4 signaling pathway, and (2) to provide experimental evidence for the development of a novel OA-targeted pharmacotherapy. Thirty-six healthy Hartley guinea pigs were randomly divided into three groups: a T140-treated group (n = 12), a phosphate buffer saline control group (n = 12) and an untreated control group (n = 12). At 2, 4, 6, 8, 10 and 12 weeks of treatment, SDF-1 in serum was quantified by enzyme-linked immunosorbent assay. At 12 weeks of treatment, the cartilage from knee tibial plateau in the knee joint was collected for H&E, Safranin-O staining and Mankin grading; measurement for mRNA levels of matrix metalloproteinases (MMP-3, MMP-9 and MMP-13), aggrecan (ACAN) and collagen II (Col II) using RT-PCR; and measurement for Col II protein levels by western blot. Results showed that SDF-1 in serum increased in the T140 group and increased in the control groups. H&E and Safranin-O staining revealed less cartilage loss in T140-treated animals compared to controls. The mRNA levels of MMP-3, MMP-9 and MMP-13 in cartilage were much lower in the T140 group than other groups, but mRNA levels of ACAN and Col II in cartilage were higher in the T140-treated group. Col II protein levels in the T140 group and control groups were different. T140 can downregulate the expression of matrix-degrading enzyme and lessen the degeneration of cartilage by blocking the SDF-1/CRCR4 signaling pathway in vivo. This mechanism may present a pharmacological target for the treatment of OA.

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Epidemiological characteristics of patellofemoral osteoarthritis in elderly Koreans and its symptomatic contribution in knee osteoarthritis

Cited by 19 publications

References 36 publications

The prevalence of radiographic and MRI-defined patellofemoral osteoarthritis and structural pathology: a systematic review and meta-analysis

The prevalence of radiographic and MRI-defined patellofemoral osteoarthritis and structural pathology: a systematic review and meta-analysis

Concordance between clinical and radiographic evaluations of knee osteoarthritis

T140 blocks the SDF-1/CXCR4 signaling pathway and prevents cartilage degeneration in an osteoarthritis disease model

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