Epidemiological characteristics of hepatocellular carcinoma in Egypt: a retrospective analysis of 1313 cases

Shaker, Mohamed; Abdella, Heba M.; Khalifa, Mohamed; Dorry, Ahmed Kamal El

doi:10.1111/liv.12209

Cited by 72 publications

(44 citation statements)

References 31 publications

(40 reference statements)

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“…Similar results were presented by Shaker et al [16] who showed that 38.6% of their cohort had more than one hepatic focal lesion. Vascular invasion was found in 23.5% in our HCC patients.…”

Section: Discussionsupporting

confidence: 78%

Association of serum levels of epidermal growth factor with disease severity in patients with unresectable hepatocellular carcinoma

Kohla¹,

Al-Haddad²,

Nada³

et al. 2015

Hepatoma Res

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Aim: Epidermal growth factor (EGF) is a mitogen for hepatocyte grown in vitro, and its expression is up-regulated during liver regeneration. EGF also plays an important role in tumor initiation and progression. The goal of this study is to assess whether EGF is associated with advanced hepatocellular carcinoma (HCC) and also whether it is a predictive factor of shortened survival. Methods: Serum EGF levels were evaluated in a total of 151 subjects: 51 patients with unresectable HCC, (21 of them were eligible for transarterial chemoembolization (TACE) and serum EGF levels were measured before and 1 week after TACE), 40 patients with chronic hepatitis without cirrhosis, 40 patients with cirrhosis, and 20 healthy controls. Patient demographic and laboratory variables were evaluated as predictive factors of survival in a Cox regression multivariate analysis using SPSS software. Results: The mean serum level of EGF in patients with HCC was 784.49 pg/mL, which was significantly higher (P < 0.05) than all other groups. Mean EGF level in cirrhotic patients was 144.69 pg/mL; in those with chronic hepatitis C without cirrhosis, it was 338.64 pg/mL; and in healthy controls, it was 297.15 pg/mL. In group Ia patients who underwent TACE, the mean serum level of EGF was 759.76 ± 287.88 pg/mL before TACE, and 801.14 ± 276.12 pg/mL 1 week after treatment (P = 0.34). On multivariate Cox regression analysis only age (P = 0.03) and higher serum EGF level (P = 0.005), were inversely correlated with overall survival. Conclusion: EGF levels were found to be significantly higher in HCC patients and together with age were the only predictors of poor survival in these patients. There was an increase in EGF levels 1 week after TACE in response to hypoxia; however, this increase was not statistically significant.

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“…Similar results were presented by Shaker et al [16] who showed that 38.6% of their cohort had more than one hepatic focal lesion. Vascular invasion was found in 23.5% in our HCC patients.…”

Section: Discussionsupporting

confidence: 78%

Association of serum levels of epidermal growth factor with disease severity in patients with unresectable hepatocellular carcinoma

Kohla¹,

Al-Haddad²,

Nada³

et al. 2015

Hepatoma Res

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“…It is well known, in addition, that HCV infection is associated with HCC carcinogenesis, especially in the Egyptian population (24). Hence it is important to further detect the potential association between HCV-induced cirrhosis and these biomarkers.…”

Section: Introductionmentioning

confidence: 99%

Stemness-Related Transcriptional Factors and Homing Gene Expression Profiles in Hepatic Differentiation and Cancer

Toraih

Fawzy

El-Falouji

et al. 2016

Mol Med

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and 6 Pulmonologist, Ministry of Health, EgyptStem cell transcriptional signature activation is an essential event in the development of cancer. This study aimed to investigate the differential expression profiles of three pluripotency-associated genes, OCT4, NANOG and SOX2, G-protein-coupled chemokine receptor 4 (CXCR4) and the ligand CXCL2, and alpha-fetoprotein (AFP) in hepatogenic differentiated stem cells and in sera of hepatitis C virus (HCV) and HCV-induced hepatocellular carcinoma (HCC) patients. Mesenchymal stem cells derived from umbilical cord blood were differentiated using hepatogenic differentiation media. Serum specimens were collected from 96 patients (32 cirrhotic HCV, 32 early HCC and 32 late HCC) and 96 controls. Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed for relative quantification of the six target genes using the Livak method. In silico network analysis was also executed to explore the pluripotency and tumorigenetic regulatory circuits in liver cancer. The expression levels of all genes declined gradually during the stages of stem cell differentiation. On univariate and multivariate analyses, NANOG, CXCR4 and AFP were significantly upregulated in late clinical stage HCC patients. In contrast, SOX2 and CXCL2 were markedly overexpressed in cirrhotic patients and could be used for clear demarcation between cirrhotic and HCC patients in our cases. In conclusion, our data highlight the potential role of the SOX2 stem cell marker and CXCL2 chemokine in liver cell degeneration and fibrogenesis in HCV-induced hepatic cirrhosis in our sample of the Egyptian population. In addition, the significant association of NANOG and CXCR4 high expression with late HCC could contribute to the acquisition of stem celllike properties in hepatic cancer and dissemination in late stages, respectively. Taken together, our results could have potential application in HCC prognosis and treatment.

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“…In Egypt, HCC is a major health problem and its incidence is increasing being related to high incidence of HCV [31]. HCC constitutes 70.48% of all liver tumors among Egyptians and represents the main complication of cirrhosis with about 21% of cirrhotic patients at risk of developing HCC [32,33].…”

Section: Hepatocellular Carcinoma (Hcc)mentioning

confidence: 99%

Comparative study of liver biopsy results in egypt over three decades

Hassan¹,

Hady²,

Helal³

et al. 2018

Gen Med Open

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Indications for liver biopsy technique were changed a lot over the recent few years. This was associated with dramatic revolution in viral diagnosis, viral vaccination and anti-viral therapy. This current work deals with a retrospective study of the prevalence of different hepatic lesions among liver biopsies received at Theodor Bilharz Research Institute within the periods from (1987 to 1989) compared to the period from (1996 to 1998) and from (2014 to 2016). It was found that the total number of liver biopsy specimens sent were not significantly changed during the three studied periods of time (p > 0.05). However, the number of liver biopsies was significantly and acutely decreased during the last two studied years (2015 and 2016) (p < 0.05). A well reported difference was also noticed in the pattern of biopsied liver lesions, being mostly bilharzial hepatitis in the eighties and nineties, while viral hepatitis came over during the new century with a marked reduction in the histopathological diagnosis of bilharziasis. Our study showed a steady increase in the histopathological diagnosis of chronic viral hepatitis between the different periods studied. On the contrary histopathological diagnosis of bilharzial liver disease was declining with time, being only about 1.6% at the period of time from 2014 to 2016. Diagnoses of autoimmune liver diseases, drug hepatitis, non-alcoholic fatty liver diseases (NAFD) and non-alcoholic steatohepatitis (NASH), were overcoming the diagnosis of bilharzial liver disease within recent years.

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Epidemiological characteristics of hepatocellular carcinoma in Egypt: a retrospective analysis of 1313 cases

Abstract: HCC is a major health problem in Egypt and its incidence is increasing. The high prevalence of HCV infection makes screening programmes and surveillance of those patients a very important tool to early detect cases of small HCCs.

Cited by 72 publications

References 31 publications

Association of serum levels of epidermal growth factor with disease severity in patients with unresectable hepatocellular carcinoma

Association of serum levels of epidermal growth factor with disease severity in patients with unresectable hepatocellular carcinoma

Stemness-Related Transcriptional Factors and Homing Gene Expression Profiles in Hepatic Differentiation and Cancer

Comparative study of liver biopsy results in egypt over three decades

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