Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China

Eastin, Carly; Eastin, Travis

doi:10.1016/j.jemermed.2020.04.006

Cited by 111 publications

(87 citation statements)

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“…The actual incidence is unknown since there are no community-based studies. While more than 90% of children with COVID-19 were described to have asymptomatic, mild, or moderate disease, new concerns emerged with reports on hyperinflammatory states or Kawasaki-like disease [2,3]. The resulting phenotypes are a combination of typical/atypical Kawasaki disease, Kawasaki shock syndrome, toxic shock syndrome, and macrophage activation syndrome/hemophagocytic lymphohistiocytosis [4,5].…”

Section: Introductionmentioning

confidence: 99%

Kawasaki-like disease in children with COVID-19

et al. 2020

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Children with Coronavirus disease 2019 (COVID-19) are being reported to have manifestations of hyperinflammatory states and/or Kawasaki-like disease. In this study, we investigated children with typical and atypical Kawasaki disease (KD) likely to be associated with COVID-19. We have reported four children with Kawasaki-like disease probably associated with COVID-19. The clinical features were consistent with incomplete KD in three patients. SARS-CoV-2 RT-PCR was positive in one and the serology was positive in one patient with negative RT-PCR. Corticosteroids, anakinra, intravenous immunoglobulin (IVIG), and acetylsalicylic acid were used in the treatment. Three patients recovered after the treatment while one patient died. The literature review revealed 36 articles describing 320 children with Kawasaki-like disease associated with COVID-19. SARS-CoV-2 RT-PCR was negative in 120 (65.5%) of 183 patients while the serology was positive in 130 (83.8%) of 155 patients. The therapeutic options have included IVIG, acetylsalicylic acid, tocilizumab, anakinra, enoxaparin, and methylprednisolone. Pediatric COVID-19 cases may present with atypical/incomplete Kawasaki-like disease. Thus, pediatricians need to be aware of such atypical presentations resembling KD for early diagnosis of COVID-19.

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Section: Introductionmentioning

confidence: 99%

Kawasaki-like disease in children with COVID-19

et al. 2020

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“…Gastrointestinal symptoms such as vomiting and diarrhoea can occur, being more common in children than in adults. The prevalence of severe and critical disease was 10.6% n in children aged <1% at diagnosis; 7.3% in children aged 1-5 years; 4.2% 6-10 years; 4.1% 11-15 years and 3% 16-17 years [14].…”

Section: Covid-19 and Childrenmentioning

confidence: 92%

“…A recent review of 72,314 cases by the Chinese Center for Disease Control and Prevention showed that about 2% of the cases were children age 0-19 years and less 1% younger than 10 years of age [12]. Most reports of children infected with SARS-CoV-2 demonstrate family contact with a proven diagnosis of the infection [13,14]. It suggests that children are just as likely to infected as adults but have fewer symptoms or risk of developing disease seriously.…”

Section: Covid-19 and Childrenmentioning

confidence: 99%

“…It suggests that children are just as likely to infected as adults but have fewer symptoms or risk of developing disease seriously. Signs and symptoms include different stages as asymptomatic, mild, moderate, severe and critical [14]. Although the majority of affected patients exhibit symptoms including a dry cough which is usually accompanied by fever and difficulty in breathing [8,15].…”

Section: Covid-19 and Childrenmentioning

confidence: 99%

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Coronavirus (Covid-19) in Children: History and Pediatric Oral Health

Coelho¹,

Credie²,

Rezende³

2020

DOBCR

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Objective: This study aims to, through a recent literature review, present the epidemiological and pediatric oral health of COVID-19. Material and Methods: A bibliographical research was carried out in the PUBMED database, with the keywords COVID-19 and dental practice, until April 5 of 2020. Discussion: Children of all ages appeared susceptible to COVID-19, and there was no significant gender difference. The participants in dental practice expose to tremendous risk of COVID-19 infection due to the face-to-face communication and the exposure to saliva, blood, and other body fluids, and the handling of sharp instruments. There is still much more to know about COVID-19, especially as concerns mortality and capacity of spreading on a pandemic level. Conclusion: Everyone who has had close contact with an infected individual is susceptible to COVID-19. Up-to-date oral health helps in the general health of the children prevent dental care during the pandemic, minimizing the risk of contamination. Healthcare guidance is being updated with frequency, as to how best to proceed in a care setting.

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“…Подобные поражения лёгких (рис. 5,6) являются причиной смерти без присоединения бактериальной и микотической суперинфекции [20]. Те процессы, которые происходят в легких и других органах, проиллюстрированы фотографиями макро-и микропрепаратов, которые были выполнены при аутопсиях в условиях ГКБ 15 им.…”

Section: рисунок 5 вирусное повреждение трахеи и бронховunclassified

Диагностика И Лечение Новой Коронавирусной Инфекции В Многопрофильном Стационаре: Опыт ГКБ №№15

Байкова

Vechorko

Дорошенко

et al. 2020

Preprint

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Статья посвящена проблемам этиологии, патогенеза, диагностики, клиники и лечения COVID-19, вызываемого коронавирусом SARS-CoV-2 на основе обзора литературных источников, а также собственного опыта курации пациентов с COVID-19 клиницистами инфекционного госпиталя на базе перепрофилированной ГКБ 15 им. О.М. Филатова. Представляло интерес изменение взглядов медицинского сообщества на патогенез и подходы к лечению данного заболевания за период пандемии.

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Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China

Cited by 111 publications

References 0 publications

Kawasaki-like disease in children with COVID-19

Kawasaki-like disease in children with COVID-19

Coronavirus (Covid-19) in Children: History and Pediatric Oral Health

Диагностика И Лечение Новой Коронавирусной Инфекции В Многопрофильном Стационаре: Опыт ГКБ №№15

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