Epidemiological characteristics, clinical manifestations and laboratory findings in 850 patients with brucellosis in Heilongjiang Province, China

Abstract

Background Brucellosis has extensive clinical spectrum, clinicians have insufficient understanding of the disease, and the misdiagnosis rate is still high. By collecting and analyzing the clinical characteristics of patients with brucellosis in Heilongjiang Province to provide guidance and reference for clinicians to make timely diagnosis and treatment. Methods The demographic and epidemiological characteristics, clinical features, complications, laboratory findings were retrospectively evaluated in 850 brucellosis patients admitted in the Department of Infectious Diseases of the First Affiliated Hospital of Harbin Medical University and the Second Hospital of Daqing from 2012 to 2017. Results Of the 850 patients, the most common clinical manifestations were fever (93.3%), joint pain (69.8%), sweating (45.2%), fatigue (38.6%), and splenomegaly (34.0%). Peripheral arthritis, spondylitis and epididymal-orchitis were the common complications. Of the 398 patients who were followed up and completed treatment, 22 (5.5%) had relapse. Conclusions Brucellosis is a multisystem disease with diverse clinical manifestations. In areas where brucellosis is endemic, the possibility of the disease should be considered in patients with unexplained fever and joints pain. In addition, the high rate of relapse is mainly due to the misdiagnosis of complications, so local CT or MRI examination is necessary for patients with joint pain and low back pain. Timely diagnosis, early detection of complications are essential to improve the prognosis and reduce relapse.

<p>Analysis of the Epidemiological, Clinical Characteristics, Treatment and Prognosis of Human Brucellosis During 2014–2018 in Huludao, China</p>

“…25 Of all the cases recorded the clinical manifestations, it was found that the most frequent symptoms were fatigue, hyperhidrosis, fever, arthralgia/myalgia, which is similar to most previous studies. [26][27][28][29] It was found that patients aged more than 60 years were more likely to had arthralgia/ myalgia than other age groups, and patients who had enlarged spleen in male were more than female; and in another study about clinical characteristics of brucellosis in different age groups, 30 it was reported that patients aged under 3 years old constituted the largest proportion (19.1%) of hepatosplenomegaly. In this study, most patients were diagnosed with acute brucellosis, and there was no statistically significant difference in clinical diagnosis between different age groups and genders, which was different from another study that reporting most (87%) patients under 15 years-old presented as acute cases.…”

Brucellosis: Evaluation of Two Hundred and Ten Cases with Different Clinical Features

“…Brucella bacterial growth in blood culture was achieved in 22 of 70 cases. Typing was possible for only 18 isolates; 14 of them were brucella melitensis and 4 were brucella abortus.The clinical and laboratory features of the patients are presented in Tables 1 and 2. The treatment regimens were a 6-week combination of oral doxycycline+rifampicin, 6 weeks of doxycycline + 21 days of streptomycin or 7 days gentamicin, 6 weeks of doxycycline+trimethoprim-sulfamethoxazole, 6 weeks of rifampicin+trimethoprim-sulfamethoxazole, 6 weeks of doxycycline + ciprofloxacin, 6 weeks of rifampicin+ ceftriaxone. Aminoglycoside combination was used mostly in osteoarticulear involvement and ceftriaxone combination was used in pregnancy.…”

“…Its broad spectrum of clinical presentations leads to delay in diagnosis and treatment. 6 The purpose of our study is to analyse the epidemiological, clinical, and laboratory findings and therapeutic features of our patients with brucellosis and compare our results with other similar studies in the literature.…”

Factors Related to Hypocalcemia in human Brucellosis: a retrospective review

“…As with complex clinical complications [17] , multiple organ damage can be caused by brucellosis,such as Brucellosis spondylitis.The incidence of meningitis and ion disorder (hyponatremia, hypokalemia and hypocalcemia) in hypocalcemia group was higher than that in normal corrected calcium group, indicating that hypocalcemia affected the occurrence of various systemic diseases, including blood system, nervous system, etc. [18] , suggesting that hypocalcemia may be associated with systemic disease in brucella patients.It has been described that CKD can cause nervous system complications through metabolic disorders (such as acidosis, hypocalcemia, hyperphosphatemia) [19] . Moreover, associated with the recurrence of hypocalcemia.…”