Epidemiological Characteristics and Survival Studies of Rhabdomyosarcoma in East Egypt: A Five-Year Multicenter Study

Badr, Mohamed; Al‐Tonbary, Youssef; Mansour, Ahmed; Hassan, Tamer; Beshir, Mohamed Refaat; Darwish, Ahmad; El-Ashry, Rasha

doi:10.5402/2012/674523

Cited by 10 publications

(16 citation statements)

References 12 publications

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“…This result was closely comparable to an an Egyptian Multicenter study which was conducted over a 5 -year period between 2004 and 2009 , and showed that the median age of patients was 6 years with 80.4% below 10 years . (19) This is similar to a recent study done in the central region of Tunisia by Missaoui N et al in 2010 who reported that almost two third of patients with RMS were diagnosed before 7 years of age. (20) This also agrees with data from the IRS IV which reported that the median age of patients with RMS was 5-year, with 72% of patients below the age of 10 years.…”

Section: Discussionsupporting

confidence: 90%

“…(3,20,23 (23) This is supported by a five-year study from East Egypt conducted between 2004 and 2009, which showed that the embryonal RMS was the most commont histopathologic subtype (61.9%), followed by alveolar (28.6%) and lastly the botryoid and spindle subtypes in 4.7% for each. (19) This is not similar to a study conducted in the Japan by Suita S, et al in 2005 ,who reported that the alveolar type accounted for 36. 8% of RMS cases, while 35.…”

Section: Discussioncontrasting

confidence: 74%

“…(3,20,21) On the other hand ,similar to our results, a more recent study from Egypt in 2012 found that the extremities ranks second after head and neck regarding the primary site of tumor. (19) These differences may be explained by the variable number of patients included in these studies. The present study described the stages of RMS in pediatric age group, as seen in Table III.…”

Section: Discussionmentioning

confidence: 98%

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Pediatric Rhabdomyosarcoma : A 7-Year Experience at King Hussein Medical Center

Mustafa¹,

Al-Jarrah²,

Hamoury³

2016

JRMS

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Objective: To evaluate the clinical characteristics and treatment outcomes of children with rhabdomyosarcoma diagnosed and treated at King Hussein Medical Center. Methods: This retrospective descriptive study was conducted by the hematology-oncology unit of pediatric department at Queen Rania Al Abdullah Hospital for Children at King Hussein Medical Center. The medical records of children with rhabdomyosarcoma were reviewed over a period of 7 years, between April 2005 end of March 2012. The age of children included in the study was less or equal to 14 years at the time diagnosis. The charts of 52 patients were reviewed regarding: patient demographics, tumor characteristics, risk stratification, treatment outcomes. Descriptive analysis using frequencies was used to describe the study variables. Results: There were 27males and 25 females with M: F ratio of 1.08:1. The median age at diagnosis was 5 years (range 0.25-13.75 years) with 80.8% below the age of 10 years. Head and neck was the most common primary site of tumor (46.2%) , followed by the extremities (21.2%). Pathologically, embryonal rhabdomyosarcoma was the most frequent subtype (90.4%). The stage frequencies were as follows: stage I (25.0 %) , stage II (9.6 %) , stage III (36.5 %) and stage IV (28.8 %). Regarding postsurgical grouping classification, group III and IV were the most prevalent, constituting 42.3% and 28.8% respectively. The 3-year event-free survival rate for patients was 55.8 % , and the 3-year overall survival rate was 61.5 %. Conclusion: Advanced stages (stage III and IV) and postsurgical groups (group III and IV) were the most commonly encountered in pediatric patients, which showed a negative effect on event free survival and overall survival rates. Epidemiological features other than gender distribution were close to the previously reported data

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Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 74%

Section: Discussionmentioning

confidence: 98%

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Pediatric Rhabdomyosarcoma : A 7-Year Experience at King Hussein Medical Center

Mustafa¹,

Al-Jarrah²,

Hamoury³

2016

JRMS

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“…RMS in children can originate from any site of body. Some researchers have showed that the head and neck region is the most common primary site in children with RMS, which accounts for 45%, while the primary site in the orbit accounts for 25-35% of patients with RMS in the head and neck region (Turner and Richmon, 2011;Badr et al, 2012;Salman et al, 2012). In this study, the most frequent positions in patients with RMS were in the orbit and eyelid, which accounted for 56.09% (23/41).…”

Section: Discussionmentioning

confidence: 71%

Clinical Character of Pediatric Head and Neck Rhabdomysarcomas: A 7-Year Retrospective Study

Zhang¹,

Zhang²,

Huang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…As many other researchers have reported, better outcome was observed in the younger patient group (<18 years old), only one of whom died during the 5 years of follow-up. In contrast, of the older patients (>18 years old), 10/15 died in the same period (Hosoi et al, 2007;Sultan et al, 2009;Badr et al, 2012). The most likely reason for this is the fact that among younger patients, embryonal RMS was the most common diagnosis (80%), while this histological type was not found in the older patient group (0.001).…”

Section: Discussionmentioning

confidence: 98%

Immunohistochemical expression of nestin in rhabdomyosarcoma: implications for clinicopathology and patient outcome

Glumac¹,

Pejić²,

Kovacevic³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Rhabdomyosarcoma (RMS) is a highly malignant cancer.Over the last two decades, prognosis for RMS patients has significantly improved, with the exception of those in the high-risk group. In order to identify new prognostic factors, we investigated the expression of nestin in RMS cells and its correlation with clinicopathological features and patient outcome. The analysis of overall survival for all patients (N = 30) revealed 1-, 2-, 3-, 4-, and 5-year survival rates of 93.3, 83.3, 66.7, 63.3, and 63.3%, respectively. Nestin overexpression significantly correlated with survival (P = 0.044). Survival of patients with ≤50% nestin-positive cells was 90, 70, and 40% after 1, 2, and 3 years, respectively, and remained unchanged until the end of the investigation period. The study group composed of patients exhibiting nestin expression in >50% of cells showed 1-, 2-, 3-, and 4-year survival rates of 95, 90, 80, and 75%, respectively, remaining stable at 75% for the fifth year of observation. A nestin-positive expression rate lower than 50% was observed more frequently in older patients (43.60 ± 27.58 years; P = 0.028). In addition, higher rates of nestin expression were observed in most embryonal RMS specimens and low-grade tumors, in early stages of the disease, and among younger patients. Our results lead us to propose nestin as possible positive prognostic factor in RMS.

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Epidemiological Characteristics and Survival Studies of Rhabdomyosarcoma in East Egypt: A Five-Year Multicenter Study

Cited by 10 publications

References 12 publications

Pediatric Rhabdomyosarcoma : A 7-Year Experience at King Hussein Medical Center

Pediatric Rhabdomyosarcoma : A 7-Year Experience at King Hussein Medical Center

Clinical Character of Pediatric Head and Neck Rhabdomysarcomas: A 7-Year Retrospective Study

Immunohistochemical expression of nestin in rhabdomyosarcoma: implications for clinicopathology and patient outcome

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