Epidemiological changes in the histological subtypes of 35,018 non-small-cell lung cancer cases in Brazil

Thuler, Luiz Cláudio Santos; Ferreira, Carlos Gil

doi:10.1016/j.lungcan.2016.04.019

Cited by 25 publications

(20 citation statements)

References 31 publications

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“…For instance, lung cancer is the second most frequent type of cancer in males with approximately 17,330 new cases identified in 2016 in Brazil [139]. Non-small-cell lung cancer (NSCLC) is a major form of lung cancer [140], and the published literature have suggested that the disruption of melatonin rhythm could increase the NSCLC incidence [141].…”

Section: Experimental Studiesmentioning

confidence: 99%

Melatonin for the prevention and treatment of cancer

et al. 2017

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The epidemiological studies have indicated a possible oncostatic property of melatonin on different types of tumors. Besides, experimental studies have documented that melatonin could exert growth inhibition on some human tumor cells in vitro and in animal models. The underlying mechanisms include antioxidant activity, modulation of melatonin receptors MT1 and MT2, stimulation of apoptosis, regulation of pro-survival signaling and tumor metabolism, inhibition on angiogenesis, metastasis, and induction of epigenetic alteration. Melatonin could also be utilized as adjuvant of cancer therapies, through reinforcing the therapeutic effects and reducing the side effects of chemotherapies or radiation. Melatonin could be an excellent candidate for the prevention and treatment of several cancers, such as breast cancer, prostate cancer, gastric cancer and colorectal cancer. This review summarized the anticancer efficacy of melatonin, based on the results of epidemiological,experimental and clinical studies, and special attention was paid to the mechanisms of action.

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Section: Experimental Studiesmentioning

confidence: 99%

Melatonin for the prevention and treatment of cancer

et al. 2017

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“…It is one of the most frequent histological subtypes and is closely related to tumor mortality 7 . Accumulating evidence indicates that LSCC is associated with many chronic diseases and disorders, including diabetes, hypertension, obesity, and metabolic syndrome 8 10 , thus dramatically increasing its clinical and economic burden 11 .…”

Section: Introductionmentioning

confidence: 99%

Nomograms to Predict Survival in Patients with Lung Squamous Cell Cancer: A Population-Based Study

Zheng

Wang

et al. 2019

J Nippon Med Sch

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Background: This study aimed to identify risk factors affecting cancer-specific survival (CSS) and overall survival (OS) in patients with lung squamous cell carcinoma (LSCC) and to develop nomograms for prognostic prediction in these patients. Methods: Patients who received an LSCC diagnosis between 2007 and 2013 were selected from the Surveillance, Epidemiology, and End Results (SEER) database. The prognostic effect of each variable on survival was evaluated with Cox regression and Kaplan-Meier analysis, and nomograms were developed to predict 3-, 5-, and 7-year CSS and OS rates. Results: Data from 23,004 patients with LSCC were analyzed. Nomograms were first developed by using variables that were significantly associated with CSS and OS and then validated by using an internal bootstrap resampling approach, which showed that they had a sufficient level of discrimination, according to the C-index. Conclusions: The nomograms satisfactorily predicted 3-, 5-, and 7-year CSS and OS rates for patients with LSCC.

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“…(5,6) Clinically advanced/ metastatic LC has recently been identified in 54.9% to 57.4% of cases at diagnosis and is on the rise in Brazil. (7,8) However, the other stages were not adequately assessed in those studies. (7,8) Knowledge of the distribution of the clinical stages of LC is essential to optimizing smoking cessation programs, as well as cancer screening, diagnosis, and treatment at the national level, whether in the public or private sector.…”

Section: Introductionmentioning

confidence: 99%

“…(7,8) However, the other stages were not adequately assessed in those studies. (7,8) Knowledge of the distribution of the clinical stages of LC is essential to optimizing smoking cessation programs, as well as cancer screening, diagnosis, and treatment at the national level, whether in the public or private sector. (9)(10)(11)(12) Therefore, using data from hospital cancer registries, the present study aimed to characterize the clinical and histological profile, as well as treatment patterns, of patients with early-stage, locally advanced, or advanced/metastatic LC, diagnosed between 2000 and 2014, in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Tumor-node-metastasis staging and treatment patterns of 73,167 patients with lung cancer in Brazil

Mello

Bergmann

Ferreira³

et al. 2020

J. bras. pneumol.

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Objective: To characterize the clinical and histological profile, as well as treatment patterns, of patients with early-stage, locally advanced (LA), or advanced/metastatic (AM) lung cancer, diagnosed between 2000 and 2014, in Brazil. Methods: This was an analytical cross-sectional epidemiological study employing data obtained for the 2000-2014 period from the hospital cancer registries of two institutions in Brazil: the José Alencar Gomes da Silva National Cancer Institute, in the city of Rio de Janeiro; and the São Paulo Cancer Center Foundation, in the city of São Paulo. Results: We reviewed the data related to 73,167 patients with lung cancer. The proportions of patients with early-stage, LA, and AM lung cancer were 13.3%, 33.2%, and 53.4%, respectively. The patients with early-stage lung cancer were older and were most likely to receive a histological diagnosis of adenocarcinoma; the proportion of patients with early-stage lung cancer remained stable throughout the study period. In those with LA lung cancer, squamous cell carcinoma predominated, and the proportion of patients with LA lung cancer decreased significantly over the period analyzed. Those with AM lung cancer were younger and were most likely to have adenocarcinoma; the proportion of patients with AM lung cancer increased significantly during the study period. Small cell carcinoma accounted for 9.2% of all cases. In our patient sample, the main treatment modality was chemotherapy. Conclusions: It is noteworthy that the frequency of AM lung cancer increased significantly during the study period, whereas that of LA lung cancer decreased significantly and that of early-stage lung cancer remained stable. Cancer treatment patterns, by stage, were in accordance with international guidelines.

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Epidemiological changes in the histological subtypes of 35,018 non-small-cell lung cancer cases in Brazil

Cited by 25 publications

References 31 publications

Melatonin for the prevention and treatment of cancer

Melatonin for the prevention and treatment of cancer

Nomograms to Predict Survival in Patients with Lung Squamous Cell Cancer: A Population-Based Study

Tumor-node-metastasis staging and treatment patterns of 73,167 patients with lung cancer in Brazil

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