Epidemiological burden of meningococcal disease in Brazil: A systematic literature review and database analysis

Almeida, Rodrigo Sini de; Spinardi, Júlia; Cané, Alejandro

doi:10.1016/j.ijid.2019.01.009

Cited by 13 publications

(25 citation statements)

References 28 publications

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“…Brazil was the first country in Latin America to report an increase in the percentage of cases associated with MenW, which was evident in RS [11]. Since 2004 there has been an increase in the number of IMD cases associated with MenW in RS.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, between 1987 and 2003, the majority of cases (73.5 %) were due to serogroup B, 25.8 % due to serogroup C and 0.7 % due to other serogroups in SC [17]. Recently, another study conducted in Brazil reported an incidence rate of 0.57 cases per 100 000 inhabitants in PR, 0.41 cases per 100 000 in SC and 0.94 cases per 100 000 in RS [11].…”

Section: Discussionmentioning

confidence: 99%

“…MCC vaccination started in 2010 in Brazil. The programme has been reported to be highly effective and has had a strong direct impact on the groups targeted for vaccination [9, 11]. Regarding IMD in Brazil, it was recently reported that MenC and MenB represent the aetiological agent in a substantial proportion of cases and that MenW was also significantly contributed to the disease burden [11].…”

Section: Discussionmentioning

confidence: 99%

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Surveillance of invasive meningococcal disease in the south of Brazil: considerations of immunization programme

Silveira

Crespo

Conrad

et al. 2021

Journal of Medical Microbiology

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Invasive meningococcal disease (IMD) is a major cause of meningitis and septicaemia worldwide. The switches in serogroup predominance contribute to the unpredictable nature of the disease with significant health impacts. The aim of this study was to determine the epidemiological profile of IMD in Rio Grande do Sul, Santa Catarina and Paraná, three states in the south of Brazil. All meningitis cases confirmed by clinical and/or laboratory criteria notified to the national information system for notifiable diseases between 2015 and 2019 were analysed. Proportions of serogroup and incidence by age were calculated. A total of 17 894 cases of IMD were reported during this period. Of these, 9029 cases (50 %) were due to serogroup C. Furthermore, serogroup W was responsible for almost half of the cases among children younger than 5 years old during 2017 and 2018, with an overall incidence of 33.3 cases per 100 000 infants. Despite the reduction in serogroup C after the introduction of meningococcal C conjugate vaccine into a childhood immunization programme in Brazil, it remains a significant healthcare issue in the south of the country. Changes in disease epidemiology were observed and serogroup W was the most common among children below 5 years of age in 2017 and 2018. Although future cost-effectiveness studies are necessary, our results could have future implications for meningococcal vaccination programmes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Surveillance of invasive meningococcal disease in the south of Brazil: considerations of immunization programme

Silveira

Crespo

Conrad

et al. 2021

Journal of Medical Microbiology

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“…Most of the cases reported are sporadic, with seasonal variations and periodic outbreaks occurring in several cities. 6 During the last 50 years, several meningococcal vaccination programmes were implemented in Brazil, providing important lessons. In the early 1970s, an epidemic of serogroup A disease, with incidence rates as high as 179 cases/100,000 population in determined regions provided the first major experience in the world with a large-scale vaccination of a polysaccharide A and C vaccine, resulting in the successful control of the epidemic one year after its implementation.…”

Section: Introductionmentioning

confidence: 99%

A critical analysis of serogroup B meningococcal disease burden in Brazil (2001–2015): implications for public health decisions

Chicuto

Moraes

et al. 2020

Human Vaccines & Immunotherapeutics

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The recent licensure of two different serogroup B recombinant protein meningococcal vaccines in Brazil emphasizes the importance of a better knowledge of the real burden of serogroup B meningococcal (MenB) disease to establish evidence-based vaccination policies. We performed an observational, descriptive study, from 2001 to 2015, analyzing the incidence and case fatality rates (CFR) of MenB disease in Brazil, according to age group and region. In the absence of any vaccine use targeting MenB disease, a significant decline of 90% in the overall incidence rates of MenB disease was observed (from 0.55 cases/100,000 habitants in 2001 to 0.05 in 2015), with declines found in all age groups during the study period. The highest incidence rates were consistently observed in infants and children 1-4 year of age, whereas adults ≥ 60 years experienced the highest CFR (33.9%). The proportion of cases with serogroup identified increased from 37.1% in 2001 to 51.5% in 2015. Despite an improvement in recent years, the quality of diagnosis is highly heterogeneous in the diverse regions, presenting important deficiencies that still prevent the possibility of a robust and reliable analysis of the burden of the meningococcal disease in Brazil. Based on the findings of this study and taking in account the unlikely indirect effect associated with the use of the new recombinant serogroup B protein vaccines, infants < 1 year is the age group to be prioritized when considering the implementation of routine immunization programmes with MenB vaccines.

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“…Twelve serogroups of Neisseria meningitidis have been characterized based on their capsular polysaccharides, although serogroups A, B, C, W, Y and X are the most clinically significant [ 2, 3 ]. Most cases of IMD occur sporadically and vary according to the age, socioeconomic conditions, geographic regions and serogroups involved; outbreaks and epidemics may occur at irregular intervals [ 4–6 ]. Since 1975, IMD is a notifiable disease in Brazil and the National Surveillance System (SNV) monitors the epidemiological characteristics of the disease.…”

Section: Introductionmentioning

confidence: 99%

Phenotypic characterization of Neisseria meningitidis strains isolated from invasive meningococcal disease in Brazil from 2002 to 2017

Gorla

Brandão

Pinhata

et al. 2020

Access Microbiology

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Introduction Invasive meningococcal disease (IMD) has a high rate of fatality and may cause severe clinical sequelae. Over the years, the epidemiology of IMD has changed significantly in various regions of the world, and laboratory surveillance of this disease is important for mapping epidemiologic changes. Aim To perform phenotypic characterization of Neisseria meningitidis strains isolated from invasive disease in Brazil from 2002 to 2017, as a complementation of the data obtained in the period of 1990–2001. Methodology In total, 8,689 isolates sent to Adolfo Lutz Institute confirmed as N. meningitidis by conventional methods were serogrouped by slide agglutination against MenA, MenB, MenC, MenE, MenW, MenX, MenY and MenZ; serotyped and serosubtyped by a whole-cell dot-blotting assay with monoclonal antibodies. Results The isolates were sent from all regions of Brazil, and the southeast region was responsible for the largest number of isolates (57.2 %). Overall, the total sample ( n =8,689) was represented by serogroups C ( n =4,729; 54.4 %), B ( n =3,313; 38.1 %), W ( n =423; 4.9 %), Y ( n =203; 2.3 %), X ( n =5; 0.1 %) and others ( n =16; 0.2 %). A shift in the prevalence of serogroups was observed in 2006, when serogroup C became the most prevalent (65.5 %), surpassing the serogroup B (21.9 %). The main isolated phenotypes were C:23:P1.14–6; B:4,7:P1.19,15; W:2a:P1.5 and W:2a:P1.5,2. Conclusion The data show an important change in the distribution of meningococcal serogroups, serotypes and subtypes occurring during 2002–2017. A continuous laboratory-based surveillance provides robust information to implement appropriate strategies to IMD control.

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Epidemiological burden of meningococcal disease in Brazil: A systematic literature review and database analysis

Cited by 13 publications

References 28 publications

Surveillance of invasive meningococcal disease in the south of Brazil: considerations of immunization programme

Surveillance of invasive meningococcal disease in the south of Brazil: considerations of immunization programme

A critical analysis of serogroup B meningococcal disease burden in Brazil (2001–2015): implications for public health decisions

Phenotypic characterization of Neisseria meningitidis strains isolated from invasive meningococcal disease in Brazil from 2002 to 2017

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