Epidemiological aspects of an outbreak of encephalomyelitis at the Royal Free Hospital, London, in the summer of 1955

Crowley, Nuala; Nelson, Merran; Stovin, Sybille

doi:10.1017/s0022172400061295

Cited by 39 publications

(18 citation statements)

References 11 publications

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“…Throughout the 1950s to 1980s however, outbreaks of CFS/ME-like illness have been reported as Bornholm disease [2], Iceland disease [3], the Royal Free Hospital epidemic [4], as well as Chronic Epstein Barr Virus Syndrome [5]. In recent decades, several formal case definitions have been released for CFS/ME [6-12], and each differ significantly in the symptoms they emphasise, as well as their exclusion criteria [13].…”

Section: Introductionmentioning

confidence: 99%

A comparison of health status in patients meeting alternative definitions for chronic fatigue syndrome/myalgic encephalomyelitis

Johnston

Brenu

Hardcastle

et al. 2014

Health Qual Life Outcomes

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BackgroundSeveral diagnostic definitions are available for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) that varies significantly in their symptom criteria. This pilot study was conducted to determine whether simple biological and clinical measures differed between CFS/ME patients meeting the 1994 Centres for Disease Control and Prevention (CDC) criteria, the International Consensus Criteria (ICC), as well as healthy controls.MethodsA total of 45 CFS/ME patients and 30 healthy controls from the South East Queensland region of Australia provided a blood sample, reported on their current symptoms, as well as aspects of their physical and social health using the Short-Form Health Survey (SF-36), and the World Health Organisation Disability Adjustment Schedule 2.0 (WHO DAS 2.0). Differences were examined using independent sample t-testing.ResultsPatients fulfilling the ICC definition reported significantly lower scores (p < 0.05) for physical functioning, physical role, bodily pain, and social functioning than those that only fulfilled the 1994 CDC definition. ICC patients reported significantly greater (p < 0.05) disability across all domains of the WHO DAS 2.0.ConclusionsThese preliminary findings suggest that the ICC identifies a distinct subgroup found within patients complying with the 1994 CDC definition, with more severe impairment to their physical and social functioning.

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Section: Introductionmentioning

confidence: 99%

A comparison of health status in patients meeting alternative definitions for chronic fatigue syndrome/myalgic encephalomyelitis

Johnston

Brenu

Hardcastle

et al. 2014

Health Qual Life Outcomes

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“…CFS or related conditions, which have been described over a long period of time in western countries3-7)have attracted a great deal of attention, particulary in the lay press. As this syndrome is apt to occur as a small or large epidemic in Western communities, many of the epidemiological reports of this syndrome have described such outbreaks [3][4][5][6][7][8], and a few reports have dealt with the prevalence and incidence in a particular population9 -14). Outbreaks of CFS have not been reported in Japan, to date.…”

mentioning

confidence: 99%

Descriptive Epidemiology of Chronic Fatigue Syndrome Based on a Nationwide Survey in Japan

Minowa

Mei²

1996

Journal of Epidemiology

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In order to clarify the epidemiological features of chronic fatigue syndrome (CFS), a nationwide survey was conducted using the Japanese version of the CDC Criteria prepared by the CFS Research Group of Japan. All clinical departments of internal medicine, pediatrics, psychiatry and neurology at university hospitals and at ordinary hospitals with 200 or more beds were surveyed. Major results were as follows: (1) Period prevalence adjusted for response rate was 0.85 (0.63 for males and 1.02 for females) per 100,000 population during the year 1992; (2) Based on the first and final dates of hospital visits, the prevalences on January 1 of 1992 and 1993 were 0.40 and 0.60 per 100,000 population, respectively, suggesting an increasing trend; (3) Reported new cases during 1992 were 301, and the response adjusted-incidence was estimated to be 0.46 per 100,000 person-years; (4) The proportion of post-infectious CFS cases was 14.8% for both sexes, and tended to be slightly higher among females than males, but was not related to age. Three clusterings of two cases were reported.

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“…Although the illness resembled infectious mononucleosis and many patients demonstrated atypical lymphocytes, negative heterophile tests were thought to exclude this syndrome. This outbreak was considered to be an example of benign myalgic encephalomyelitis, but the possibility was raised that a second agent was responsible for causing a similar syndrome (Crowley et at., 1957). …”

Section: Infectionmentioning

confidence: 99%

Viruses, Immunity, and Mental Disorders

Kurstak¹,

Lipowski²,

Morozov³

1987

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Epidemiological aspects of an outbreak of encephalomyelitis at the Royal Free Hospital, London, in the summer of 1955

Cited by 39 publications

References 11 publications

A comparison of health status in patients meeting alternative definitions for chronic fatigue syndrome/myalgic encephalomyelitis

A comparison of health status in patients meeting alternative definitions for chronic fatigue syndrome/myalgic encephalomyelitis

Descriptive Epidemiology of Chronic Fatigue Syndrome Based on a Nationwide Survey in Japan

Viruses, Immunity, and Mental Disorders

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