Epidemiological Applications of Assessing Mosquito Exposure in a Malaria-Endemic Area

Sagna, Aloïse; Poinsignon, Anne; Remoué, Franck

doi:10.1016/b978-0-12-805360-7.00012-5

Cited by 28 publications

(19 citation statements)

References 75 publications

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“…It provides for each participant a proxy of the individual level of exposure to Anopheles bites and thus, is more appropriate for reflecting the inter-individual heterogeneity of exposure in natural setting. Numerous studies have evidenced the Anopheles gSG6-P1 salivary peptide represents a reliable and complementary tool to entomological methods for assessing spatial and temporal heterogeneity of exposure to Anopheles bites at the individual level [35].…”

Section: Discussionmentioning

confidence: 99%

“…On the contrary, children from the high exposure group (∆OD gSG6-P1 > 1. 35) from Dar-es-Salam had a significantly higher IgG median value than children from Petessou (p = 0.001), indicating that children from the high exposure group from Dar-es-Salam were higher exposed to Anopheles than did children from Petessou.…”

Section: Study Population Characteristics Parasitological and Entomomentioning

confidence: 95%

“…Individuals with ΔOD gSG6-P1 < 1.15 were considered as low exposed and individuals with ΔOD gSG6-P1 > 1. 35 were considered as high exposed to Anopheles bites low exposure group from each site. On the contrary, children from the high exposure group (∆OD gSG6-P1 > 1.…”

Section: Study Population Characteristics Parasitological and Entomomentioning

confidence: 99%

“…Interestingly, the intensity of Anopheles exposure was assessed at an individual level by evaluating the IgG level specific to the Anopheles gambiae gSG6-P1 salivary peptide. For the last decade, new immune-epidemiological tools have been developed that aimed at evaluating the level of exposure to mosquito bites at population and individual level [35]. These innovative tools are based on the measure of human antibody responses to salivary proteins of arthropod vector injected during the bite.…”

mentioning

confidence: 99%

“…gambiae saliva has been identified and validated as a pertinent biomarker of Anopheles bites [36][37][38]. It represents a proxy of human exposure to Anopheles bites and is a reliable tool for assessing spatial and temporal heterogeneity of exposure at the individual level [35]. The gSG6-P1 salivary peptide is specific to the Anopheles genus, antigenic, easy to synthesize and highly conserved between Anopheles mosquitoes.…”

mentioning

confidence: 99%

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Pattern of antibody responses to Plasmodium falciparum antigens in individuals differentially exposed to Anopheles bites

Aka

Traoré

Sagna

et al. 2020

Malar J

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Background: In malaria-endemic areas, human populations are frequently exposed to immunomodulatory salivary components injected during mosquito blood feeding. The consequences on pathogen-specific immune responses are not well known. This study evaluated and compared the humoral responses specific to merozoite stage vaccine candidates of Plasmodium falciparum, in children differentially exposed to Anopheles bites in a natural setting. Methods:The cross-sectional study was carried out in Bouaké (Côte d'Ivoire) where entomological data and blood samples from children (0-14 years) were collected in two sites with similar malaria prevalence. Antibody (IgG, IgG1, IgG3) responses to PfAMA1 and PfMSP1 were evaluated by ELISA. Univariate and multivariate analysis were performed to assess the relationship between the immune responses to P. falciparum antigens and exposure to Anopheles bites in the total cohort and in each site, separately. The individual level of exposure to Anopheles bites was evaluated by quantifying specific IgG response to the Anopheles gSG6-P1 salivary peptide, which represents a proxy of Anopheles exposure.

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Section: Discussionmentioning

confidence: 99%

Section: Study Population Characteristics Parasitological and Entomomentioning

confidence: 95%

Section: Study Population Characteristics Parasitological and Entomomentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Pattern of antibody responses to Plasmodium falciparum antigens in individuals differentially exposed to Anopheles bites

Aka

Traoré

Sagna

et al. 2020

Malar J

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Use of Anopheles salivary biomarker to assess seasonal variation of human exposure to Anopheles bites in children living near rubber and oil palm cultivations in Côte d'Ivoire

Sadia-Kacou

Yobo

Adja

et al. 2019

Parasite Epidemiology and Control

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Environmental changes related to agricultural practices and activities can impact malaria transmission. In the objective to evaluate this impact on the human-vector contact, the level of human exposure to Anopheles vector bites was assess by an immuno-epidemiological indicator based on the assessment of the human IgG antibody response to the Anopheles gambiae gSG6-P1 salivary peptide, previously validated as a pertinent biomarker.Two cross-sectional surveys were carried out in the dry and rainy season in three villages with intensive agricultural plantations (N'Zikro with rubber cultivation, Ehania-V5 and Ehania-V1 with palm oil exploitation) and in a control village without plantations (Ayébo). Overall, 775 blood samples were collected in filter papers from children aged 1 to 14 years-old for immunological analysis by ELISA. The IgG levels to the gSG6-P1 salivary peptide significantly differed between studied villages both in the dry and the rainy seasons (P < 0.0001) and were higher in agricultural villages compared to the control area. In particular, the level of specific IgG in Ehania-V5, located in the heart of palm oil plantations, was higher compared to other agricultural villages. Interestingly, the level of specific IgG levels classically increased between the dry and the rainy season in the control village (P < 0.0001) whereas it remained high in the dry season as observed in the rainy season in agricultural villages.The present study indicated that rubber and oil palm plantations could maintain a high level of human exposure to Anopheles bites during both the dry and rainy seasons. These agricultural activities could therefore represent a permanent factor of malaria transmission risk.

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Evolutionary Parasitology

Schmid‐Hempel

2021

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Parasites are ubiquitous and shape almost every aspect of their hosts, including physiology, behaviour, life histories, the structure of the microbiota, and entire communities. Hence, parasitism is one of the most potent forces in nature and, without parasites, the world would look very different. The book gives an overview over the parasite groups and the diversity of defences that hosts have evolved, such as immune systems. Principles of evolutionary biology and ecology analyse major elements of host–parasite interactions, including virulence, infection processes, tolerance, resistance, specificity, memory, polymorphisms, within-host dynamics, diseases spaces, and many other aspects. Genetics is always one of the key elements in these topics. Modelling, furthermore, can predict best strategies for host and parasites. Similarly, the spread of an infectious disease in epidemiology combines with molecular data and genomics. Furthermore, parasites have evolved ways to overcome defences and to manipulate their hosts. Hosts and parasites, therefore, continuously co-evolve, with changes sometimes occurring very rapidly, and sometimes requiring geological times. Many infectious diseases of humans have emerged from a zoonotic origin, in processes governed by the basic principles discussed in the different sections. Hence, this book integrates different fields to study the diversity of host–parasite processes and phenomena. It summarizes the essential topics for the study of evolutionary parasitology and will be useful for a broad audience.

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Epidemiological Applications of Assessing Mosquito Exposure in a Malaria-Endemic Area

Cited by 28 publications

References 75 publications

Pattern of antibody responses to Plasmodium falciparum antigens in individuals differentially exposed to Anopheles bites

Pattern of antibody responses to Plasmodium falciparum antigens in individuals differentially exposed to Anopheles bites

Use of Anopheles salivary biomarker to assess seasonal variation of human exposure to Anopheles bites in children living near rubber and oil palm cultivations in Côte d'Ivoire

Evolutionary Parasitology

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