Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012–2016

Wang, Jiayu; Teng, Zheng; Cui, Xiaoqing; Li, Chongshan; Pān, Hào; Zheng, Yaoxian; Mao, Shenghua; Yang, Yuying; Wu, Li; Guo, Xia; Zhang, Xi; Zhu, Yongzhang

doi:10.1038/s41426-017-0011-z

Cited by 64 publications

(61 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of patients were under 5 years of age in this study, which is possibly associated with the incomplete immunity of children [3]. The incidence rate in boys with HFMD was higher than that of girls, with 1.4:1 sex ratio, which was similar to the results of previous studies [10,49,52]. We suspected that poor hygiene, more outdoor activities, and host factors may be related to that phenomenon [22].…”

Section: Discussionsupporting

confidence: 88%

“…Additionally, different serotypes of EV were distinct in their monthly distribution. Significantly, CVA-6 was the predominant pathogen of the small HFMD peak in autumn, and CVA-10 and CVA-16 were prevalent in the beginning of summer (the peak in May), which was similar to that observed in Shanghai and southern Vietnam to a certain extent [10,52]. The discrepancy in the monthly distribution of CVA-6 and CVA-10 in different regions may be attributed to the adaptive changes in the pathogens.…”

Section: Discussionsupporting

confidence: 69%

See 1 more Smart Citation

Co-circulation of coxsackieviruses A-6, A-10, and A-16 causes hand, foot, and mouth disease in Guangzhou city, China

Xie

Yang

et al. 2020

BMC Infect Dis

View full text Add to dashboard Cite

Background: Hand, foot, and mouth disease (HFMD) is a common infectious disease occurring in children under 5 years of age worldwide, and Enterovirus A71 (EV-A71) and Coxsackievirus A16 (CVA-16) are identified as the predominant pathogens. In recent years, Coxsackievirus A6 (CVA-6) and Coxsackievirus A10 (CVA-10) have played more and more important role in a series of HFMD outbreaks. This study aimed to understand the epidemic characteristics associated with HFMD outbreak in Guangzhou, 2018. Methods: The clinical and laboratory data of 1220 enterovirus-associated HFMD patients in 2018 were analysed in this study. Molecular diagnostic methods were performed to identify its serotypes. Phylogenetic analyses were depicted based on the complete VP1 gene. Results: There were 21 enterovirus serotypes detected in Guangzhou in 2018. Three serotypes of enterovirus, CVA-6 (364/1220, 29.8%), CVA-10 (305/1220, 25.0%), and CVA-16 (397/1220, 32.5%), were identified as the causative pathogens and accounted for 87.3% among all 1220 HFMD patients. In different seasons, CVA-6 was the predominant pathogen of HFMD during autumn, and CVA-10 as well as CVA-16 were more prevalent in summer. Patients infected by CVA-6, CVA-10 or CVA-16 showed similar clinical features and laboratory characteristics, and the ratios of severe HFMD were 5.8, 5.9, and 1.5% in the three serotypes. Phylogenetic analyses of VP1 sequences showed that the CVA-6, CVA-10, and CVA-16 sequences belonged to the sub-genogroup E2, genogroup E, and genogroup B1, respectively. Conclusions: CVA-6, CVA-10, and CVA-16 were the predominant and co-circulated serotypes in Guangzhou China, 2018, which should be the new target for prevention and control of HFMD. Our findings provide useful information for diagnosis, treatment, and prevention of HFMD.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 69%

Co-circulation of coxsackieviruses A-6, A-10, and A-16 causes hand, foot, and mouth disease in Guangzhou city, China

Xie

Yang

et al. 2020

BMC Infect Dis

View full text Add to dashboard Cite

show abstract

“…The clinicians could also test the specimens as the conditions required. Throat and/or faecal swabs were sent directly to microbiology laboratories at the local CDCs, where the presence of EV-A71, CV-A16, CV-A6, CV-A10, and other EVs was con rmed by real-time PCR [11]. The vast majority of children with HFMD are treated in two designated hospitals, the Children's Hospital of Fudan University and the Xinhua Hospital a liated to Shanghai Jiao Tong University School of Medicine.…”

Section: Participants and Specimensmentioning

confidence: 99%

“…CV-A16 and EV-A71 are responsible for most of the large outbreaks [10]. Among healthy individuals in Shanghai, 50.5% and 54.2% are positive for neutralising antibodies against EV-A71 and CV-A16, respectively [11]. Beginning in 2008, CV-A6 has been increasingly reported as a cause of HFMD outbreaks worldwide, and it may be associated with more severe diseases than typical HFMD [4,[12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Neonatal hand, foot, and mouth disease due to Coxsackievirus A6 in Shanghai

Qiao³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Evidence of hand, foot, and mouth disease (HFMD) in neonates is limited. The aim of this study was to evaluate the clinical symptoms, pathogens, possible transmission routes, and prognosis of neonatal HFMD in Shanghai. Methods: This was a case-control study based on the HFMD registry surveillance system. All neonates and infected family members were enrolled between 2016 and 2017 in Shanghai. Neonates with HFMD were followed for at least half a year. Detailed questionnaires, medical history, and physical examination were recorded. Routine blood examination, liver and renal function, immunophenotypes of peripheral blood lymphocytes (CD3, CD4, and CD8 T-cells; NK cells), immunoglobulin (Ig) M, IgG, and IgA, and cytokine interleukin (IL-1β, IL-2R, IL-6, IL-8, IL-10, and TNF-α) levels were measured. All rectal swab specimens were collected and genotyped for enterovirus, and phylogenetic analysis based on the VP1 sequences of coxsackievirus A6 (CV-A6) was performed to investigate molecular and evolutionary characteristics. T-test or nonparametric test was used to evaluate the differences. Logistic analysis was applied to calculate the risk of clinical manifestations in the group of HFMD neonates and their paired siblings. Results: There were 16 neonates among the 12608 diagnosed patients with HFMD, accounting for 0.13%. All neonatal infections were transmitted by other members of the family, mainly the elder siblings, and were caused by CV-A6. CV-A6 was the emerging and predominant causative agent of HFMD in Shanghai. None of the neonates with HFMD experienced fever, onychomadesis, or severe complications. However, two elder sibling patients showed lethargy, and one developed hypoperfusion. In the elder siblings with HFMD, the proportion of white blood cells was generally higher than in neonates with HFMD. The immunologic function of the neonates with HFMD was basically normal. The levels of inflammatory markers were higher in both neonates and elder siblings with HFMD compared to age-matched controls. The clinical symptoms receded about one week after onset. None of the neonates had sequelae. Conclusions: In our study, CV-A6 infection in neonates was benign, but had the character of family clustering. Due to the two-child policy in China, elder siblings may be the main route of HFMD transmission.

show abstract

“…Several outbreaks were still reported and resulted in dozens of deaths for decades, recently (Le, Nguyen, Nguyen, & Pham, 2019;Wang, Teng, et al, 2018;Yin, Wang, Wang, Xiao, & Ji, 2018). EV71 infection causes typical hand-foot-and-mouth disease, aseptic meningitis, encephalomyelitis, acute flaccid paralysis, or even neurologic and psychiatric disorders (Chang et al, 2004;Chang et al, 2007;Wu et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Host relieves lnc‐IRAK3‐3‐sequestered miR‐891b to attenuate apoptosis in Enterovirus 71 infection

Liao

Chen

et al. 2019

Cellular Microbiology

View full text Add to dashboard Cite

Enterovirus 71 (EV71) is an emerging life-threatening pathogen particularly in the Asia-Pacific region. Apoptosis is a major pathogenic feature in EV71 infection.However, which molecular mechanism participating in EV71-induced apoptosis is not completely understood. Long noncoding RNAs (lncRNAs), a newly discovered class of regulatory RNA molecules, govern a wide range of biological functions through multiple regulatory mechanisms. Whether lncRNAs involved in EV71-induced apoptosis was investigated in this study. We conducted an apoptosis-oriented approach by integrating lncRNA and mRNA profilings. lnc-IRAK3-3 is downregulated in EV71 infection and plays an important role in EV71 infection-induced apoptosis. Compensation of lnc-IRAK3-3 in EV71 infection promoted cell apoptosis wherein GADD45β expression was increased and further triggered caspase3 and PARP cleavage. Using bioinformatics analysis and functional assays, lnc-IRAK3-3 could functionally sequester miR-891b and GADD45β 3′UTR whereas miR-891b showed the inhibitory activity on GADD45β expression. Taken together, lnc-IRAK3-3 has the ability capturing miR-891b to enforce GADD45β expression and eventually promotes apoptosis. On the contrary, host cells suppress lnc-IRAK3-3 to relieve lnc-IRAK3-3sequestered miR-891b, restrain GADD45β, and attenuate apoptosis in EV71 infection that prevent host cells from severe damages. We discover a new molecular mechanism by which host cells counteract EV71-induced apoptosis through the lnc-IRAK3-3/miR-891b/GADD45β axis partially.

show abstract

Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012–2016

Cited by 64 publications

References 52 publications

Co-circulation of coxsackieviruses A-6, A-10, and A-16 causes hand, foot, and mouth disease in Guangzhou city, China

Co-circulation of coxsackieviruses A-6, A-10, and A-16 causes hand, foot, and mouth disease in Guangzhou city, China

Neonatal hand, foot, and mouth disease due to Coxsackievirus A6 in Shanghai

Host relieves lnc‐IRAK3‐3‐sequestered miR‐891b to attenuate apoptosis in Enterovirus 71 infection

Contact Info

Product

Resources

About