Epidemiological and Serological Profile of Hepatitis B Virus in an Urban Area in Mali

Abstract

The objective of our study was to evaluate hepatitis B virus (HBV) infection in an urban population. This longitudinal study was conducted in Bamako District and Kati Commune. After a preparatory phase, the persons who accepted the protocol were assessed for HBsAg. HBsAg carriers had blood collection for HBeAg assay, viral load assessment, genotyping, DNA mutation testing, and severity of hepatic fibrosis and necrosis. At the end of this study, 1475 persons were included, of which 195 had HBsAg positive confirmed, that is to say 13.97%. The mean age of HBsAg positive patients was 35.11 ± 11.12 years with a sex ratio of 2.68. HBeAg was found in 8.9% of the patients tested for this antigen. The viral load was undetectable in 10.52% of patients and greater than 2000 IU/mL in 32.24% of cases. Fibrosis ≥ F2 and necrosis ≥ A2 were found in respectively 19.72% and 6.80% of cases. Genotype E was found in 91.6 patients and an R249S mutation observed in 39.04% of cases. Conclusion: HBV infection has a serious impact on socioeconomic development in Mali because it affects mainly the young male population, hence the need to organize preventive measures effectively.

Etiologies of Liver Cytolysis in the Service of Hepato-Gastroenterology of the Gabriel Toure University Hospital

“…This frequency of HBV infection in our context is reported by a previous study which found at least one serum marker of HBV in 60.2% of patients with HCC [9]. A study recent report has reported the prevalence of HBs Antigen to be 14.7% of the general population [7]. A recent study reported the prevalence of the HBs Antigen to 14.7% of the general population [7].…”

“…The sex ratio was 1.73 in our study, which was contrary to that found by Hachicha et al [6] which was 0.44. This difference could be explained by the frequency of chronic HBV carriage in humans in our [7]. The predominance of cytolysis in farmers and housewives were reported by our study.…”

“…A study recent report has reported the prevalence of HBs Antigen to be 14.7% of the general population [7]. A recent study reported the prevalence of the HBs Antigen to 14.7% of the general population [7]. In the work Debonne et al [10], after steatosis (52%), chronic hepatitis with or without cirrhosis viral predominance B is the second largest diagnostic framework (33% of cases).…”