Epidemiological and prognostic factors involved in upper gastrointestinal bleeding: results of a French prospective multicenter study

Abstract

UGIB still occurs mainly as a result of peptic ulcers and portal hypertension in France, and causes significant rates of mortality. There is scope for improvement via better prevention (better use of UGIB-facilitating drugs), endoscopic therapy, and management of co-morbidities.

Peptic ulcer disease: one in five is related to neitherHelicobacter pylorinor aspirin/NSAID intake

“…Peptic ulcer disease (PUD) remains a common condition worldwide . PUD accounts for 38% of upper gastrointestinal bleeding in France . Although H. pylori infection prevalence has declined in developed and developing countries over the past 10 years, due to improving sanitary conditions and the widespread use of antibiotics, H. pylori infection remains a major cause of PUD .…”

Upper Gastrointestinal Bleeding Due to a Peptic Ulcer

“…2 The case fatality rate among hospitalized patients with upper gastrointestinal bleeding has decreased over the past 20 years and ranges from 2.1 to 2.5% in U.S. nationwide database studies 3,4 to 10% in large, prospective European observational studies. 5,6 The rate of death among patients who are already hospitalized for another condition when upper gastrointestinal bleeding develops is approximately 3 to 4 times as high as the rate among patients who are admitted to the hospital for upper gastrointestinal bleeding. 5 Peptic ulcers, which are primarily due to Helicobacter pylori infection or the use of nonsteroidal antiinflammatory drugs (NSAIDs), occur in the stomach or duodenum and are the most frequent cause of upper gastrointestinal bleeding.…”

Upper gastrointestinal bleeding risk scores: Who, when and why?

“…Many risk factors are known to influence the outcome in UGIB setting. Age, comorbidities, presence of shock, endoscopic diagnosis, haemoglobin values at the time, ulcers' size, stigmata of recent haemorrhage and need for a blood transfusion have all been described as significant risk factors for rebleeding and death [4][5][6][7][8] .…”