Epidemiological and microbiological aspects of healthcare-associated infections in Ukraine during the 2009–2019 period

Konechnyi, Yulian; Panas, Marta; Tymchuk, I. V.; Havur, Oksana; Borysiuk, O; Hubytska, Iryna; Журахівська, Л. Р.; Konechna, Roksolana; Korniychuk, Olena

doi:10.32394/pe.75.09

Cited by 5 publications

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“…Salmanov et al 98 provide further details on these and another study has pointed out that extensive antibiotic resistance is also seen in many other countries. 101 Healthcare-associated infections have decreased in Ukraine in the last decade, 63 with most nosocomial infections originating from surgery, pregnancy, childbirth and the perinatal period. 63 A review by Konechnyi et al, 63 63 Extended spectrum beta-lactamase-producing bacteria were common.…”

Section: Antibiotic Resistancementioning

confidence: 99%

“…101 Healthcare-associated infections have decreased in Ukraine in the last decade, 63 with most nosocomial infections originating from surgery, pregnancy, childbirth and the perinatal period. 63 A review by Konechnyi et al, 63 63 Extended spectrum beta-lactamase-producing bacteria were common. 63 Finally, a 2020 study isolated a large number of strains with multi-resistance to several antibiotics: 49.1% of Klebsiella pneumoniae isolates, 32.6% of Staphylococcus haemoliticus isolates, 36.9% of Staphylococcus aureus isolates and 30.6% of Streptococcus pyogenes isolates.…”

Section: Antibiotic Resistancementioning

confidence: 99%

“…63 A review by Konechnyi et al, 63 63 Extended spectrum beta-lactamase-producing bacteria were common. 63 Finally, a 2020 study isolated a large number of strains with multi-resistance to several antibiotics: 49.1% of Klebsiella pneumoniae isolates, 32.6% of Staphylococcus haemoliticus isolates, 36.9% of Staphylococcus aureus isolates and 30.6% of Streptococcus pyogenes isolates. 127 The factors that contributed to antibiotic resistance in children could have included lack of parental knowledge.…”

Section: Antibiotic Resistancementioning

confidence: 99%

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Systematic review of health and disease in Ukrainian children highlights poor child health and challenges for those treating refugees

Ludvigsson

Лобода

2022

Acta Paediatrica

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Aim Millions of Ukrainian children have been internally displaced or fled to other countries because of the Russian war. This systematic review focused on their health needs and future challenges for clinicians. Methods A systematic literature search of the Medline, Embase and MedRxiv databases from 1 January 2010 to 31 March 2022 identified 1628 papers on the health of Ukrainian children and 112 were relevant to this review. Results In 2019, under‐5 mortality was 8 per 1000 live births in Ukraine. Underweight and adverse childhood experiences, including child abuse, were frequent compared to other European countries, while childhood obesity seemed less common. Alcohol consumption was common in women of reproductive age, including during pregnancy, risking foetal alcohol syndrome. Neonatal screening programmes provided low coverage. Vaccine hesitancy was common and vaccination rates were low. Other concerns were measles, HIV, antibiotic resistance and multi‐resistant tuberculosis. Many children are expected to suffer from psychological and physical trauma due to the war. Other healthcare challenges include low COVID‐19 vaccination rates and a preference for secondary and tertiary care, rather than primary care. Many people cannot afford medication. Conclusion Ukrainian children often have poor health and host countries need to be aware of their needs.

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Section: Antibiotic Resistancementioning

confidence: 99%

Section: Antibiotic Resistancementioning

confidence: 99%

Section: Antibiotic Resistancementioning

confidence: 99%

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Systematic review of health and disease in Ukrainian children highlights poor child health and challenges for those treating refugees

Ludvigsson

Лобода

2022

Acta Paediatrica

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“…The situation in Ukraine is particularly challenging due to a combination of factors, including inadequate infection control measures and a potential problem of under-registration. This manuscript builds upon our previous work [5] and aims to provide a comprehensive overview of the registered cases of HAIs in Ukraine from 2009 to 2021. By analyzing this data, we hope to shed light on the prevalence and trends of HAIs in Ukraine, thereby contributing to the global understanding of these infections and informing public health strategies.…”

Section: Introductionmentioning

confidence: 99%

Data of Prevalence of Healthcare-Associated Infections in Ukraine During the 2009–2022 Period

Konechnyi,

Lavryk,

Konechna

et al. 2024

ujlm

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Health Care Associated Infections (HCAI) present a worldwide health challenge, yet the situation regarding HCAI in Ukraine has not been extensively examined. This study aimed to evaluate the reported prevalence of HCAI in Ukraine between 2009-2022. Data from the "Public Health Center of the Ministry of Health of Ukraine" was scrutinized. Yearly, an approximate 4109 HCAI cases have been documented. By age demographics, the 2009-2022 average was 75.8±6.6% for adults and 24.2±6.3% for individuals aged 0-17. It's projected that the minimum annual HCAI cases in Ukraine surpass 1 million, with the reported rate being less than 0.1%.

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“…В Україні структура та поширеність ІАНМД, а також антимікробна резистентність збудників малодосліджені [13]. З'ясування етіологічних чинників шпитальних інфекцій дихальних шляхів (ІДШ), а також докладна характеристика їх чутливости до антибактеріальних засобів -актуальна проблема сучасної медицини.…”

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Species Spectrum of Bacterial Factors of Nosocomial Respiratory Infections in Hospitals of Lviv and the Prevalence of Antimicrobial Resistance Among Them

Korniychuk¹,

Shykula²,

Khorkavyi³

et al. 2022

Lʹviv. klin. visn.

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Introduction. Healthcare-associated infections (HAIs) are a pressing problem in the health care system. Respiratory tract infections (RTI) are the second most common group of HAIs. One of the determining factors in the development of nosocomial pneumonia, which is predominantly bacterial in origin, is the properties and level of virulence of microbial factors. Early nosocomial pneumonia occurs when the upper respiratory tract microbiota infects the respiratory tract. Late nosocomial pneumonia is caused by nosocomial strains of microorganisms, characterized by multidrug resistance to antibiotics and disinfectants high levels of virulence, which include P. aeruginosa, Acinetobacter spp., Enterobacteriaceae family, MRSA. Unfortunately, in Ukraine, the structure and prevalence of HAIs and the antimicrobial resistance of pathogens are extremely poorly studied. The aim of the study. Therefore, the study investigates the species spectrum and antimicrobial resistance of the main causative agents of respiratory tract infections. Materials and methods. A study of microbial factors of nosocomial respiratory tract infections in 4 hospitals in Lviv. 205 patients of intensive care units diagnosed with RTI (36.6 %) were examined. Statistical analysis of the results was performed using the standard package of the program “Microsoft Excel 2010”. Microbiological diagnostics were performed following current regulations in the specialty “Bacteriology and Virology” and “Guidelines for Clinical Microbiology” of the 12th revision of the American Association for Microbiology. Microbiological diagnostics is performed in the research laboratory of the Department of Microbiology of Danylo Halytsky Lviv National Medical University. Results. The species profile of the detected pathogens of RTI indicates that among 14 representatives of different taxa, the gram-positive microbiota predominates, but the quantitative level of seeding per gram-negative microbiota accounts for 70.17 %. Among the isolates – factors of HAIs, multidrug-resistant (MDR) share accounted for 62.8 %. 3 strains are classified as pan drug resistant (PDR): 2 – P. putida and 1 – P. aeruginosa. Of the gram-positive microbiota, Enterococcus spp., represented mainly by E. faecalis and E. faecium, was most often detected in clinical material. E. faecalis was most often detected in the clinical material of the gram-positive microbiota. E. faecalis isolates were characterized by pronounced resistance to penicillins (including oxacillin), cephalosporins, fluoroquinolones, erythromycin and azithromycin, clindamycin with preserved sensitivity to vancomycin and linezolid. Pseudomonas aeruginosa isolates showed absolute sensitivity to colistin. Among other antibiotics, the most effective in terms of the number of sensitive strains were carbapenems – imipenem (57.5 %) and meronem (55.0 %). Only 37.5 % of the cultures were sensitive to tobramycin and tegicillin, an inhibitor of the protected cephalosporin antibiotic, sulfperazone. The genus Staphylococcus was among the causative agents of pneumonia other than Staph. aureus subsp. aureus, will Staph. haemolyticus, Staph. lugdunensis. Moreover, only one strain of methicillin-resistant Staphylococcus was detected. Most cases of RTI (57.4%) of patients in intensive care units occurred within 48 hours after the installation of a tracheostomy or intubation tube. Conclusions. According to the results of microbiological diagnostics, it has been established that the main etiological factors of nosocomial pneumonia associated with medical care are opportunistic microorganisms – Pseudomonas aeruginosa and enterococci. 62.8 % of strains were MDR. Furthermore, the results of monitoring the antibiotic resistance of hospital strains of microorganisms show their differences in different institutions of Lviv and the connection exclusively with the hospital environment. Therefore, optimization of antimicrobial treatment of nosocomial pneumonia is possible only based on the broader use of microbiological research results, constant monitoring of the microbiological status of patients in intensive care units, hospitality (distribution and properties of pathogens in hospitals).

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Epidemiological and microbiological aspects of healthcare-associated infections in Ukraine during the 2009–2019 period

Cited by 5 publications

References 0 publications

Systematic review of health and disease in Ukrainian children highlights poor child health and challenges for those treating refugees

Systematic review of health and disease in Ukrainian children highlights poor child health and challenges for those treating refugees

Data of Prevalence of Healthcare-Associated Infections in Ukraine During the 2009–2022 Period

Species Spectrum of Bacterial Factors of Nosocomial Respiratory Infections in Hospitals of Lviv and the Prevalence of Antimicrobial Resistance Among Them

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