Epidemiological And Histopathologic Study Of Rhabdomyosarcoma cases in a tertiary Care hospital of Peshawar

Abstract


 Aim: This study aimed to find out rhabdomyosarcoma’s (RMS) histopathological and immunohistochemical features. Settings: The current study was carried out at the Department of Pathology, Section of Histopathology, Khyber Teaching Hospital Peshawar. The study duration was between from 1st January 2015 to 30th of December 2020. Results: In the current study, all the 300 occurrences were found to be relevant. The most prevalent rhabdomyosarcoma was embryonal rhabdomyosarcoma (ERMS) (87.4%), followed by alveolar rhabdomyosarcoma (ARMS) (9.4%). In the current study we found that embryonal rhabdomyosarcomas was most frequent in males (64%). ERMS were 16.1 percent found in the genitourinary system followed by neck and head region (46.7%). Most samples displayed positive Desmin and MyoD1 immunohistochemistry staining. Conclusions: It is consistent with previously published rhabdomyosarcoma data from all across the globe that our patients' epidemiologic information and microscopic findings are consistent with one other.

Covid as an immunosuppressive disease a Review

“…Particularly, among 191 COVID-19 patients investigated at two hospitals in Wuhan, D-dimer levels > 1 g/L at admission suggested an 18-fold increase in the odds of dying before discharge. Be aware that DIC caused by a systemic infection displays an early, overly inflammatory response that is only linked to endothelial damage [19].…”

“…Why respiratory symptoms are so widespread is explained by the disease's pathogenesis: In actuality, the virus is able to penetrate host cells thanks to the angiotensin-converting enzyme 2 (ACE2) protein, which is widely present in the lungs. However, endothelial cells also express ACE2 [12][13][14], and these cells also express other important clinical outcomes that are often seen in COVID-19 patients, including hypertension and thrombosis. The endothelium of the kidney, one of the major human organs, has been suggested as the virus' potential target (disease, pulmonary embolism, cerebrovascular and neurologic diseases).…”