Abstract:Cutaneous Leishmaniasis is the most common form of Leishmaniasis, it affects the skin and cause a painless and chronic papule at the site of the infected sand fly bite. The current study amied to assess the associated-risk determinants for cutaneous leishmaniasis in patients with diabetes compared to patients without diabetes. The direct stain method used to diagnose the cutaneous leishmaniasis. Blood samples were collected form 45 confirmed cutaneous leishmaniasis patients for the purpose of measuring HBA1C for patients with cutaneous leishmaniasis. The results of current study showed that 276 out of 315 (87.61%) were infected with cutaneous leishmaniasis by microscopic examination. Significant differences (P<0.05) were recorded in the prevalence of cutaneous leishmaniasis according to patient sex and the infected males 65.21% more than infected females 34.78%. Eleven out of 45 cutaneous leishmaniasis patients were suffered from diabetes with prevalence 24.44%. A high association between diabetes and increase in the size of the skin lesions was recorded in current study, the prevalence of diabetic patients with large skin lesions 17.78% higher than the prevalence of diabetic patients with small skine lesions 6.67%, also an association between diabetes and increased the number of cutaneous skin lesions was reported. The prevalence of cutaneous leishmaniasis patients with diabetes who suffered from multiple skin lesions was 13.33% higher than the prevalence of cutaneous leishmaniasis patients with diabetes who had a single skin lesions 11.11% and an association between diabetes and non-response to treatment of cutaneous leishmaniasis patients was recorded, the prevalence of cutaneous leishmaniasis patients with diabetes who did not respond to treatment was 15.56% higher than the prevalence of cutaneous leishmaniasis patients with diabetes who responded to treatment 8.89%. The results of current study demonstrated a significant relationship between diabetes and cutaneous leishmanasis in distinct risk determinants. Also, the study showed that the diabetes increased the severity of active cutaneous leihmaniasis.