Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth

Abstract

Menstrual cycle-related injury and repair and coinciding hormonal cycling appears to affect myometrial stem cells that, at a certain stage of fibroid development, often obtain cytogenetic aberrations and mutations of Mediator complex subunit 12 (MED12). Mammalian target of rapamycin (mTOR), a master regulator of proliferation, is activated in many of these tumors, possibly by mechanisms that are similar to some human fibrosis syndromes and/or by mutation of upstream tumor suppressor genes. Animal models of the disease support some of these dysregulated pathways in fibroid etiology or pathogenesis, but none are definitive. All of this suggests that there are likely several key mechanisms involved in the disease that, in addition to increasing the complexity of uterine fibroid pathobiology, offer possible approaches for patient-specific therapies. A final model that incorporates many of these reported mechanisms is presented with a discussion of their implications for leiomyoma clinical practice.

Fucoidan Inhibits the Proliferation of Leiomyoma Cells and Decreases Extracellular Matrix-Associated Protein Expression

“…Some patients suffer from leiomyoma, apart from hysterectomy, and most therapeutic treatments only provide temporary effectiveness [12]. Postoperative complications can be relieve by using conventional medical treatment, but the cost related to ULs is considerable.…”

Association between expression of nuclear receptor co‑activator 5 protein and prognosis in postoperative patients with osteosarcoma

“…The primary reason for this is that the mechanism of pathogenesis is not clear. The formation and development of the tumor is a multifactorial, multi-stage and a gradual process; early diagnosis and timely intervention are essential for the prognosis of patients (5). In previous years, the associations between cell proliferation and cell signaling have become an area of interest (6,7).…”

Medical Management of leipmyomas-emphasis for different geographical regions

“…Brakhta et al reviewed the role of Vit D in uterine biology and found that Vit D deficiency has been associated with increased leiomyomatosis in afro-american group as found by other workers like Baird et al [57,58] which is associated with decreased Vit D absorption due to increase melanin concentrations associated with decreased Vit D R (VDR) concentrations. They demonstrated 1,25 dihidroxy Vit D acts as an antifibrotic factor inhibiting proliferation of immortalized human uterine fibroid cells HuL M cells [59][60][61] .…”