Epidemiological and diagnostic aspects of oral squamous cell carcinoma

Abstract

Available data in United Stales on morbidity, mortality and survival is reviewed and trends discussed. Oral squamous cell carcinoma is a small problem in numerical terms, but is a highly lethal disease. The diagnosis is not difficult for the competent pathologist but problems arise in the diagnosis and prognosis of potentially malignant conditions. Our understanding of the behavior of dysplastic lesions is limited and any attempts to determine individuals “at risk” should be encouraged.

Overexpression of phosphorylated nuclear factor-kappa B in tonsillar squamous cell carcinoma and high-grade dysplasia is associated with poor prognosis

“…20,21 Our clinical data including survival, recurrence and tobacco use in the patients with squamous cell carcinoma of the tonsil are essentially compatible with reports in the literature.…”

Expression of oncogenes in human tumours with special reference to the head and neck region

“…The patients that were staged as I or II SCC all had signifieantly redueed expression of the myc oneogene, 2 of which have since died and one suffered a reeurrenee. The 2 patients who died suffered from SCC of the tongue and this site has been reported by many workers to have a poor prognosis (91,92). The report by Yokota et al (67) discussed in the previous section also indicated a correlation between c-myc expression with advaneed and aggressive primary tutnours.…”

A study on the clinical profile of ulcers and membranous lesions of oral cavity and oropharynx

“…He also suggested that hydrocortisone administered patients with recurrent aphthous ulceration exerts an effect on both lymphocytes and epithelial cells. 7 Silvermen et al (1977) compared 25 patients with primary herpetic gingivostomatitis found there was no association. Their findings were based on cytological examination, antibody titer and actual isolation of the herpes virus.…”