Epidemiological and Clinicopathological Trends of Breast Cancer in Chinese Patients During 1993 to 2013

Wen, Shi Wu; Li, Ying; Han, Yingjie; Zhang, Fan; Wang, Yingzhe; Linghu, Rui Xia; Zhang, Xingyang; Yang, Junlan

doi:10.1097/md.0000000000000820

Cited by 27 publications

(27 citation statements)

References 29 publications

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“…However, BC etiology is far from being fully understood in developing countries such as Central African Republic (CAR). Large differences have been observed in the behaviour of the tumour, clinical manifestation, treatment response and prognosis [8]. …”

Section: Introductionmentioning

confidence: 99%

Epidemiology of breast cancer: retrospective study in the Central African Republic

et al. 2016

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BackgroundBreast cancer is recognised as a major public health problem in developing countries; however, there is very limited evidence about its epidemiology in the Central African Republic. The aim of this study was to investigate the epidemiological and histopathological characteristics of breast cancer in Bangui.MethodsThis is a retrospective study based on the data collected from pathological anatomy records from 2003 to 2015 in Bangui. A questionnaire was designed to collect information and data was analysed using descriptive and inferential statistical methods.ResultsThe mean age was 45.83 (SD = 13.5) years. The age group of 45–54 years represented the majority of the study population (29.3%). Over 69.5% of the women were housewives with a moderate economic status (56.9%). Less than 14% of the study population had a level of academic degree and 85.6% lived in cities. The breast cancer prevalence was 15.27%. The age-standardized incidence and death by world population (ASW) were 11.19/100,000 and 9.97/100,000 respectively. 50–54 years were most affected. Left breast cancer is mainly common and the time between first symptoms and consultation is more than 48 months. Most (69%) of the samples analysed were lumpectomy. The most common morphology of breast cancer was invasive ductal carcinoma (64.9%). Scarff Bloom Richardson III was the main grade in both common pathological types, but their proportion showed no significant increase along with time (χ2 = 7.06, p = 0.54). Invasion of regional lymph node differed significantly among the pathological type of breast cancer (χ2 = 24.6, p = 0.02). Surgery and chemotherapy were appropriate treatment yet 84.5% of the cases died.ConclusionThe findings of this study showed that breast cancer is common and mostly affected women. Epidemiological trends are more or less common to those of developing countries with a predominance of invasive ductal carcinoma. However, most of the women studied live in an urban area and developed the disease in advanced stage. The establishment of an appropriate framework will effectively contribute to promoting the early detection and reducing the incidence of this disease in the population.Electronic supplementary materialThe online version of this article (doi:10.1186/s12889-016-3863-6) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Epidemiology of breast cancer: retrospective study in the Central African Republic

et al. 2016

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“…In China, BC patients <50 years old account for 46% of the total cases (4), with the peak prevalence observed in the 45 to 55 years old age (5)(6)(7)(8). Meanwhile, the highest mortality is observed in even younger age i.e.…”

Section: Introductionmentioning

confidence: 99%

Multicenter cross‑sectional screening of the BRCA gene for Chinese high hereditary risk breast cancer populations

et al. 2018

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Abstract. Due to lack of systematic reviews, BRCA, DNA Repair Associated (BRCA) mutations in the Chinese population are not completely understood. The following study investigates the prevalence and type of BRCA mutations in Chinese patients with high hereditary risk of breast cancer (BC).Patients Drwere recruited from 14 cities between October 2015 and February 2016, and were selected based on family and personal medical history. BRCA mutations were analyzed by collecting blood samples from all participants. 437 BC patients were included. A total of seventy-six (17.4%) mutation carriers were identified with no geographic difference. The mutation rate in the early-onset BC patients was lower compared to family history of breast/ovarian cancer (OC), bilateral BC, male BC, BC&OC or meeting ≥2 criteria (9.2 vs. 21.7, 24.0, 22.2, 16.7 and 24.3%, respectively, P=0.007). A total of 61 mutation sites were identified (BRCA1 32, BRCA2 29) including 47.5% novel sites and extra 10 variants of uncertain significance. A total of five sites were repeated in more than one unrelated patient. A total of 11 sites were associated with hereditary breast and ovarian cancer syndrome, two of which were confirmed by family pedigrees. Compared with BRCA -patients, patients with BRCA1 mutation tended to be triple-negative BC (P<0.001), whereas patients with BRCA2 mutation were more likely to be hormone receptor positive

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“…A recent epidemiological study demonstrated that the luminal B HER2-negative breast cancer had the highest incidence among these five molecular subtypes, and >40% patients are Chinese women (6). Although luminal B HER2-negative breast cancer expresses hormone receptors, the curative effect of hormone therapy and conventional chemotherapy is unsatisfactory (7).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic T lymphocyte associated antigen 4 expression predicts poor prognosis in luminal B HER2-negative breast cancer

Lan

Wen

et al. 2018

Oncol Lett

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Epidemiological and Clinicopathological Trends of Breast Cancer in Chinese Patients During 1993 to 2013

Abstract: Supplemental Digital Content is available in the text

Cited by 27 publications

References 29 publications

Epidemiology of breast cancer: retrospective study in the Central African Republic

Epidemiology of breast cancer: retrospective study in the Central African Republic

Multicenter cross‑sectional screening of the BRCA gene for Chinese high hereditary risk breast cancer populations

Cytotoxic T lymphocyte associated antigen 4 expression predicts poor prognosis in luminal B HER2-negative breast cancer

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