Epidemiological and clinical features of hMPV, RSV and RVs infections in young children

Manoha, Catherine; Espinosa, Sophie; S, Aho; Huet, Frédéric; Pothier, Pierre

doi:10.1016/j.jcv.2006.12.005

Cited by 116 publications

(135 citation statements)

References 36 publications

(44 reference statements)

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“…Em um estudo realizado em Taiwan, das 523 crianças infectadas por algum vírus, 32,5% eram menores de 1 ano de idade, 37,7% tinham entre 1 e 3 anos, e 17,2% entre 3 e 6 anos 23 . As crianças acometidas por RVH normalmente apresentam idade superior à daquelas acometidas por outros vírus como o VSRH, por exemplo, que são geralmente detectados em crianças menores de 1 ano 24,25 . No entanto, em nosso estudo, a maioria dos casos positivos para VSRH apresentava idade superior a 24 meses.…”

Section: Discussionunclassified

Frequent respiratory pathogens of respiratory tract infections in children attending daycare centers

Bonfim¹,

Nogueira²,

Simas³

et al. 2011

J Pediatr (Rio J)

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Objectives: To identify and characterize respiratory viruses that infect children from daycare centers with symptoms of respiratory infection and to evaluate the association of clinical and epidemiological disease data with the identified virus. Methods:We conducted a study between 2003 and 2005 in 176 children with respiratory infection symptoms attending a municipal daycare center. Samples from nasopharyngeal secretion were tested by reverse transcriptase polymerase chain reaction and positive samples for picornavirus were sequenced.Results: All 782 collected samples were analyzed and 31.8% were positive for at least one of the studied respiratory viruses. Respiratory infections were characterized by the presence of mild symptoms of the upper respiratory tract, the most common of which were runny nose and cough. In the 2 years of study, most cases of infection occurred in autumn and winter, but respiratory viruses were detected throughout all the study period. Conclusions:Respiratory viruses and respiratory infections caused by them are part of the daily life of children attending daycare centers. Our results show the great impact that respiratory infections have on these children and suggest that more attention must be paid to viral pathogens. Resultados: Todas as 782 amostras coletadas foram analisadas, e 31,8% foram positivas para algum dos vírus respiratórios estudados. As infecções respiratórias foram caracterizadas pela presença de sintomas moderados do trato respiratório superior, sendo os mais comuns coriza e tosse. Em 2 anos de estudo, a maioria dos casos de infecção ocorreram no outono e no inverno, mas vírus respiratórios foram detectados ao longo de todo o período de estudo. J Pediatr (Rio J) Conclusões:Vírus respiratórios e as infecções respiratórias causadas por eles fazem parte do cotidiano de crianças que frequentam creches. Nossos resultados mostram o grande impacto gerado pelas infecções respiratórias nessas crianças e sugere que uma maior atenção deve ser dispensada aos patógenos virais.J Pediatr (Rio J). 2011;87(5):439-44: Vírus respiratórios, infecção respiratória aguda, crianças de creche.

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Section: Discussionunclassified

Frequent respiratory pathogens of respiratory tract infections in children attending daycare centers

Bonfim¹,

Nogueira²,

Simas³

et al. 2011

J Pediatr (Rio J)

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“…However, the pathogenic role of hBoV is not clear because other viruses have been frequently detected in hBoV-positive samples from children with acute respiratory tract infection (ARTI) (Longtin et al 2008). Similarly, hMPV is a new member of the Paramyxoviridae family, Pneumovirus subfamily (Chan et al 2007), showing a incidence rate between 3.9-9% in young children with ARTI (Manoha et al 2007). Molecular techniques are powerful tools to search for respiratory pathogens that may be present in clinical samples, especially from patients suffering from respiratory infections (Manning et al 2006).…”

mentioning

confidence: 99%

Detection of human bocavirus and human metapneumovirus by real-time PCR from patients with respiratory symptoms in Southern Brazil

Pilger¹,

Cantarelli

Amantéa

et al. 2011

Mem. Inst. Oswaldo Cruz

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The introduction of newer molecular methods has led to the discovery of new respiratory viruses, such as human metapneumovirus (hMPV) and human bocavirus (hBoV), in respiratory tract specimens. We have studied the occurrence of hMPV and hBoV in the Porto Alegre (PA) metropolitan area, one of the southernmost cities of Brazil, evaluating children with suspected lower respiratory tract infection from May 2007-June 2008. A real-time polymerase chain reaction method was used for amplification and detection of hMPV and hBoV and to evaluate coinfections with respiratory syncytial virus (RSV), influenza A and B, parainfluenza 1, 2 and 3, human rhinovirus and human adenovirus. Of the 455 nasopharyngeal aspirates tested, hMPV was detected in 14.5% of samples and hBoV in 13.2%. A unique causative viral agent was identified in 46.2% samples and the coinfection rate was 43.7%. For hBoV, 98.3% of all positive samples were from patients with mixed infections. Similarly, 84.8% of all hMPV-positive results were also observed in mixed infections. Both hBoV and hMPV usually appeared with RSV. In summary, this is the first confirmation that hMPV and hBoV circulate in PA; this provides evidence of frequent involvement of both viruses in children with clinical signs of acute viral respiratory tract infection, although they mainly appeared as coinfection agents

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“…106(3): 316-321, May 2011 Human rhinovirus (HRV) is typically associated with mild upper respiratory tract infections and exacerbation of asthma in children (Gern & Busse 1999, Manoha et al 2007, Mackay 2008, Kelly & Busse 2008. HRV is a member of the Picornaviridae family and is composed of a nonenveloped particle with a positive-sense single-stranded RNA genome.…”

mentioning

confidence: 99%

“…Due to advances in nucleic acid amplification, we can now detect HRV and determine when HRV is the causative agent of lower respiratory tract illness (LRTI) (Choi et al 2006, Miller et al 2007, Gerna et al 2009, Louie et al 2009). HRV is frequently detected in children diagnosed with bronchiolitis and pneumonia (Manoha et al 2007, Miller et al 2007, Louie et al 2009). Additionally, HRV can cause severe complications in patients that are immunocompromised (Malcolm et al 2001) or have underlying chronic disorders (Kim & Hodinka 1998, Glezen et al 2000, Cheuk et al 2007, Dreschers et al 2007.…”

mentioning

confidence: 99%

Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent

Paula

Carneiro

Yokosawa

et al. 2011

Mem. Inst. Oswaldo Cruz

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Epidemiological and clinical features of hMPV, RSV and RVs infections in young children

Cited by 116 publications

References 36 publications

Frequent respiratory pathogens of respiratory tract infections in children attending daycare centers

Frequent respiratory pathogens of respiratory tract infections in children attending daycare centers

Detection of human bocavirus and human metapneumovirus by real-time PCR from patients with respiratory symptoms in Southern Brazil

Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent

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