Epidemiological and clinical characteristics of the first 557 successive patients with COVID-19 in Pernambuco state, Northeast Brazil

Magalhães, Jurandy Júnior Ferraz de; Mendes, Renata Pessôa Germano; Silva, Caroline Targino Alves da; Silva, Severino Jefferson Ribeiro da; Guarines, Klarissa Miranda; Pena, Lindomar

doi:10.1016/j.tmaid.2020.101884

Cited by 29 publications

(14 citation statements)

References 19 publications

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“…Similar to other Latin American countries, such as Brazil, Chile and Ecuador, [ 2 , 13 , 49 ], our results confirm that the highest rate of SARS-CoV-2 infection in Colombia occurs mainly in younger age groups (median age of 38 years), and that most fatal cases affect the elder population. These results contribute to the understanding of the epidemiological behavior of SARS-CoV-2 across different population groups and emphasize the need for prioritizing vaccination in particularly vulnerable at-risk groups, such as the elderly ( Table S1 ) [ 34 ].…”

Section: Discussionsupporting

confidence: 88%

Evolution and Epidemic Spread of SARS-CoV-2 in Colombia: A Year into the Pandemic

et al. 2021

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Current efforts to understand the epidemiology, transmission dynamics and emergence of novel SARS-CoV-2 variants worldwide has enabled the scientific community to generate critical information aimed at implementing disease surveillance and control measures, as well as to reduce the social, economic and health impact of the pandemic. Herein, we applied an epidemic model coupled with genomic analysis to assess the SARS-CoV-2 transmission dynamics in Colombia. This epidemic model allowed to identify the geographical distribution, Rt dynamics and predict the course of the pandemic considering current implementation of countermeasures. The analysis of the incidence rate per 100,000 inhabitants carried out across different regions of Colombia allowed visualizing the changes in the geographic distribution of cases. The cumulative incidence during the timeframe March 2020 to March 2021 revealed that Bogotá (8063.0), Quindío (5482.71), Amazonas (5055.68), Antioquia (4922.35) and Tolima (4724.41) were the departments with the highest incidence rate. The highest median Rt during the first period evaluated was 2.13 and 1.09 in the second period; with this model, we identified improving opportunities in health decision making related to controlling the pandemic, diagnostic testing capacity, case registration and reporting, among others. Genomic analysis revealed 52 circulating SARS-CoV-2 lineages in Colombia detected from 774 genomes sequenced throughout the first year of the pandemic. The genomes grouped into four main clusters and exhibited 19 polymorphisms. Our results provide essential information on the spread of the pandemic countrywide despite implementation of early containment measures. In addition, we aim to provide deeper phylogenetic insights to better understand the evolution of SARS-CoV-2 in light of the latent emergence of novel variants and how these may potentially influence transmissibility and infectivity.

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Section: Discussionsupporting

confidence: 88%

Evolution and Epidemic Spread of SARS-CoV-2 in Colombia: A Year into the Pandemic

et al. 2021

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“…The first confirmed SARS-CoV-2 infection in Pernambuco was reported in the second week of March (12 March 2020) in the 11th epidemiological week ( Figure 1 B) comprising an elderly couple returning from Italy on 28 February [ 39 ], only 16 after the first confirmed case in Brazil (25 February 2020) ( Figure 1 B—top panel). In the 21st epidemiological week, the Pernambuco state reached the first peak of cases followed by a second peak at the 31st epidemiological week ( Figure 1 B—top panel).…”

Section: Resultsmentioning

confidence: 99%

Multiple Introductions Followed by Ongoing Community Spread of SARS-CoV-2 at One of the Largest Metropolitan Areas of Northeast Brazil

Paiva

Guedes

Docena

et al. 2020

Viruses

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Multiple epicenters of the SARS-CoV-2 pandemic have emerged since the first pneumonia cases in Wuhan, China, such as Italy, USA, and Brazil. Brazil is the third-most affected country worldwide, but genomic sequences of SARS-CoV-2 strains are mostly restricted to states from the Southeast region. Pernambuco state, located in the Northeast region, is the sixth most affected Brazilian state, but very few genomic sequences from the strains circulating in this region are available. We sequenced 101 strains of SARS-CoV-2 from patients presenting Covid-19 symptoms that reside in Pernambuco. Phylogenetic reconstructions revealed that all genomes belong to the B lineage and most of the samples (88%) were classified as lineage B.1.1. We detected multiple viral introductions from abroad (likely from Europe) as well as six local B.1.1 clades composed by Pernambuco only strains. Local clades comprise sequences from the capital city (Recife) and other country-side cities, corroborating the community spread between different municipalities of the state. These findings demonstrate that different from Southeastern Brazilian states where the epidemics were majorly driven by one dominant lineage (B.1.1.28 or B.1.1.33), the early epidemic phase at the Pernambuco state was driven by multiple B.1.1 lineages seeded through both national and international traveling.

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“…In Brazil, until mid-September 2020, most people who tested positive for COVID-19 were aged 30 to 59 years and 73% of deaths were reported among people over 60 years [26][27] .…”

Section: Discussionmentioning

confidence: 99%

Variáveis associadas ao desfecho clínico de pacientes hospitalizados por COVID-19

Desiderio¹,

Fabio²,

Cárnio

et al. 2021

Rev. Med. (São Paulo)

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Introdução: Compreender a fisiopatologia da COVID-19 e fatores associados à evolução grave dessa doença é primordial para o estabelecimento de melhores condutas preventivas, diagnósticas e terapêuticas no combate ao novo coronavírus. Objetivo: Identificar as características sociodemográficas e clínicas associadas ao desfecho clínico de pacientes hospitalizados com diagnóstico de COVID-19 em um serviço privado de um município do interior paulista. Método: Incluíram-se os dados sociodemográficos e clínicos de 117 pacientes hospitalizados com diagnóstico de COVID-19, atendidos no período de julho a dezembro de 2020. Os dados foram analisados por meio do teste não paramétrico Qui-Quadrado de Pearson e o Teste Exato de Fisher, com adoção do nível de significância estatística de 5% (p<0,05). Resultados: A maior parte dos pacientes hospitalizados pertencia ao sexo masculino, com idade entre 61 a 70 anos, permaneceu em enfermaria por 8,7 dias sendo que 29,9% evoluíram para óbito. Hipertensão arterial e baixa saturação de oxigênio representaram, respectivamente, a comorbidade e o fator de gravidade mais frequentes. Identificou-se associação entre a variável desfecho com as variáveis idade superior a 64 anos e alteração da função renal. Conclusões: Entre pacientes hospitalizados com diagnóstico de COVID-19, o desfecho clínico associou-se aos fatores de gravidade, faixa etária e alteração da função renal.

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Epidemiological and clinical characteristics of the first 557 successive patients with COVID-19 in Pernambuco state, Northeast Brazil

Cited by 29 publications

References 19 publications

Evolution and Epidemic Spread of SARS-CoV-2 in Colombia: A Year into the Pandemic

Evolution and Epidemic Spread of SARS-CoV-2 in Colombia: A Year into the Pandemic

Multiple Introductions Followed by Ongoing Community Spread of SARS-CoV-2 at One of the Largest Metropolitan Areas of Northeast Brazil

Variáveis associadas ao desfecho clínico de pacientes hospitalizados por COVID-19

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