Epidemiological and Clinical Characteristics of Patients With Coronavirus Disease-2019 in Shiyan City, China

Liu, Long; Xu, Lei; Xiao, Xiao; Yang, Jing; Li, Jian; Ji, Manshan; Du, Weixing; Tan, Huabing; Zhu, Jian; Li, Bei; Zhou, Jin; Liu, Weiyong; Wu, Jianguo; Liu, Zhixin

doi:10.3389/fcimb.2020.00284

Cited by 33 publications

(50 citation statements)

References 28 publications

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“…Most of COVID-19 patients in Shiyan city are mild cases 4 . In order to further study the level of chemokine in mild COVID-19 patients, we detected the level of chemokine in the serum of mild COVID-19 patients admitted to Xiyuan Hospital and Renmin Hospital in Shiyan City.…”

Section: Discussionmentioning

confidence: 99%

“…Globally, by September 2020, there have been 31,425,029 con rmed cases of COVID-19, including 967,164 deaths (https://covid19.who.int/). According to the epidemiological statistics, most of the COVID-19 (about 80%) belong to the mild 3,4 . Although the city of Shiyan is located in Hubei Province, most of the COVID-19 patients there had mild cases 4 .…”

Section: Introductionmentioning

confidence: 99%

“…According to the epidemiological statistics, most of the COVID-19 (about 80%) belong to the mild 3,4 . Although the city of Shiyan is located in Hubei Province, most of the COVID-19 patients there had mild cases 4 . For this reason, it is necessary to study the immunological characteristics of mild COVID-19 patients and nd a suitable therapeutic strategy on the basis.…”

Section: Introductionmentioning

confidence: 99%

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The higher expression of monocyte chemotactic protein 1 in mild COVID-19 patients is correlation with the inhibition of IFN signaling

Guo

Zhu

et al. 2020

Preprint

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Background: The level of chemokine was markedly elevated in severe COVID-19 patients. But the role of chemokine in mild COVID-19 has not yet been established. However, most of the COVID-19 patients in Shiyan City, China, had mild cases. The purpose of this study is to evaluate the level of chemokine in mild COVID-19 patients and to explore the correlation between chemokine and host immune response.Methods: In this study, the level of chemokine in the serum for COVID-19 patients in Shiyan City was detected by ELISA. The expression of chemokine receptor and other signal molecular was detected by real-time PCR. Results: We first demonstrated that COVID-19 patients are characterized by higher levels of chemokine. Meanwhile, monocyte chemotactic protein 1 (MCP-1) has shown higher expression in patients with mild cases of COVID-19. The receptor of MCP-1, CCR2 was also found to be expressed at higher levels in the same mild COVID-19 patients. Finally, the higher expression of MCP-1 in mild COVID-19 patients is correlated with the inhibition of IFN signaling. Conclusion: These findings add to our understanding of the immune-pathologic mechanisms of SARS-CoV-2 infection, and provide potential therapeutic targets and strategies. MCP-1 may be an effective indicator in mild patients, and early use of interferon has a good antiviral therapeutic effect.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The higher expression of monocyte chemotactic protein 1 in mild COVID-19 patients is correlation with the inhibition of IFN signaling

Guo

Zhu

et al. 2020

Preprint

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“…2019 novel coronavirus, 2019-nCoV, also known as SARS-CoV-2, can cause serious pneumonia. Although its toxicity is weaker than SARS-CoV, it's more susceptible and more transmissible to crow 1 . Up to 6 o'clock in Apr.…”

Section: Introductionmentioning

confidence: 99%

Exploration of prognostic factors for critical COVID-19 patients：a nomogram analysis

Wang

et al. 2020

Preprint

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To discuss influencing factors on critical COVID-19 patient’s prognosis, construct a basic model and predict their mortality risks. Retrospectively analyzed the general condition and respective laboratory biomarkers of critical patients with duration≥24 h from Feb. 10th, 2020 to Mar. 30th, 2020 to separate them into a survival group and death group based on their clinical features. Multiple logistic regression analysis was performed to assess risk factors for critical COVID-19 patient’s and a nomogram was constructed based on screened risk factors. A receiver operating curve (ROC) was created to evaluate the accuracy of the nomogram. Multi-factor Logistic recovery analysis results show: Age, Peripheral blood leucocyte count,Lymphocyte percentage, Thrombocyte count and Hyper C-reactive protein are single danger factors of critical COVID-19 patient’s mortality risk (p＜0.05). ROC curve indicates Nomogram predictive model AUC is 0.958 (95%CI: 0.923-0.993), which has high predictive value. Findings from this study suggest advanced age, high peripheral blood leucocyte count, high hyper C-reactive protein, low lymphocyte percentage and low thrombocyte count are risk factors of critical COVID-19 patient’s death.The Nomogram model is helpful for timely intervention to reduce the incidence of critical COVID-19 patients.

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“…Globally, by October 2020, there have been 38,394,169 con rmed cases of COVID-19, including 1,089,047 deaths (https://covid19.who.int/). According to the epidemiological statistics, most of the are classi ed as mild 3,4 . Most of the COVID-19 patients in Shiyan city had mild cases 4 .…”

Section: Introductionmentioning

confidence: 99%

Higher expression of monocyte chemotactic protein 1 in mild COVID-19 patients may be correlated with the inhibition of IFN signaling

Guo

Zhu

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The level of chemokines was markedly elevated in severe COVID-19 patients. But the role of chemokines in mild COVID-19 has not yet been established. However, most of the COVID-19 patients in Shiyan City, China, had mild cases. The purpose of this study is to evaluate the level of chemokines in mild COVID-19 patients and explore the correlation between chemokines and host immune response.Methods: In this study, the level of chemokines in the serum for COVID-19 patients in Shiyan City was detected by ELISA. The expression of chemokine receptors and other signal molecules was measured by real-time PCR.Results: We first demonstrated that COVID-19 patients are characterized by higher level of chemokines. Meanwhile, monocyte chemotactic protein 1 (MCP-1) has also shown higher expression in patients with mild cases of COVID-19. The receptor of MCP-1, CCR2, was also found to be expressed at higher level in the same mild COVID-19 patients. Finally, we found the downregulation of interferon regulatory factor 3 (IRF3) was significantly negative correlated with the concentration of MCP-1 in mild COVID-19 patients.Conclusion: Higher expression of MCP-1 in mild COVID-19 patients may be correlated with the inhibition of IFN signaling. The finding adds our understanding to the immune-pathologic mechanisms of SARS-CoV-2 infection, and provides potential therapeutic targets and strategies.

show abstract

Epidemiological and Clinical Characteristics of Patients With Coronavirus Disease-2019 in Shiyan City, China

Cited by 33 publications

References 28 publications

The higher expression of monocyte chemotactic protein 1 in mild COVID-19 patients is correlation with the inhibition of IFN signaling

The higher expression of monocyte chemotactic protein 1 in mild COVID-19 patients is correlation with the inhibition of IFN signaling

Exploration of prognostic factors for critical COVID-19 patients：a nomogram analysis

Higher expression of monocyte chemotactic protein 1 in mild COVID-19 patients may be correlated with the inhibition of IFN signaling

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