Epidemiological and clinical analysis of hepatitis virus A infections during three successive outbreaks in Sfax (Tunisia) between 2007 and 2010

Gargouri, Saba; Berrajah, Lamia; Ayadi, Imen; Messedi, Emna; Jallouli, H.; Hammami, Adnène; Karray-Hakim, Héla

doi:10.1684/mst.2015.0491

Cited by 7 publications

(9 citation statements)

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“…Among the patients diagnosed during 2007-2010 [7], 35 and 33% belonged to age groups 6-10 years and 11-15 years, respectively, which confirms that susceptibility to HAV is shifting from early age to older children and even adolescents and young adults. However, this shift was more prominent in urban areas than rural ones since the mean age of patients in these regions was 14.8 and 8.5 years, respectively.…”

Section: Endemicity Patterns Of Hepatitis a Virus Infectionmentioning

confidence: 57%

“…The annual and monthly distribution of hepatitis A cases from 2000 to 2011 showed an endemic circulation of HAV with an increase in the incidence of the disease during the fall and winter season [7]. Importantly, this distribution highlighted similar waves of large outbreaks during 2002-2005, in comparison with those of 2007-2010, suggesting the cyclical trend of HAV infection in Tunisia.…”

Section: Endemicity Patterns Of Hepatitis a Virus Infectionmentioning

confidence: 78%

“…In Tunisia, HAV infection is still common, but its epidemiology is undergoing a gradual shift. Indeed, improvements in hygiene and socioeconomic conditions have led to changes in the pattern of the age-specific seroprevalence of anti-HAV antibodies; specifically, the prevalence of anti-HAV antibodies in the age group under 10 years declined from 91% in the 1980s [5] (center east of Tunisia), with the occurrence of severe forms [7]. The increase in the incidence of hepatitis A cases involved nearly all regions of the governorate, including urban and rural areas.…”

Section: Endemicity Patterns Of Hepatitis a Virus Infectionmentioning

confidence: 99%

“…Up to date, few investigations on the molecular epidemiology have been performed in Tunisia. In order to characterize HAV strains during the large outbreaks occurred in Sfax, Tunisia, during 2007-2010 [7], a molecular epidemiological study was carried out [10]. Amplification of VP1/2A region of HAV RNA by nested RT-PCR was performed on the serum samples for 159 patients with available epidemiological information [7].…”

Section: Molecular Epidemiology Of Hepatitis a Virus Infectionmentioning

confidence: 99%

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Epidemiological Aspects of Hepatitis A: Endemicity Patterns and Molecular Epidemiology

Gargouri¹,

Fki-Berrajah²,

Ayadi³

et al. 2020

Hepatitis a and Other Associated Hepatobiliary Diseases

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Improvements in hygiene and socioeconomic conditions in many parts of the world have led to an epidemiological shift in hepatitis A with a transition from high to low endemicity. Consequently, in these areas, higher proportion of symptomatic disease among adolescents resulting in large-scale community outbreaks has been described. In Tunisia, an increase in the average age at the time of infection has been reported, hence resulting in regular outbreaks, especially household and primary school epidemics. Molecular investigation of such outbreaks, based on the determination of viral genotype and genetic relatedness between hepatitis A virus (HAV) strains, is a useful tool to identify the potential source of HAV contamination but also to assess the virus molecular dynamics over time, such as the introduction of a new genotype or a specific clustering of HAV strains according to the geographical origin. In Sfax city, (Center-East of Tunisia), only HAV strains of genotype IA are circulating. In rural areas, HAV infection is still highly endemic with probably a water-borne transmission pattern. Nevertheless, the considerable genetic heterogeneity observed in urban areas highlights the changing pattern of hepatitis A epidemiology in these settings. Further molecular studies are strongly needed to better understand HAV epidemiology in Tunisia.

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Section: Endemicity Patterns Of Hepatitis a Virus Infectionmentioning

confidence: 57%

Section: Endemicity Patterns Of Hepatitis a Virus Infectionmentioning

confidence: 78%

Section: Endemicity Patterns Of Hepatitis a Virus Infectionmentioning

confidence: 99%

Section: Molecular Epidemiology Of Hepatitis a Virus Infectionmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiological Aspects of Hepatitis A: Endemicity Patterns and Molecular Epidemiology

Gargouri¹,

Fki-Berrajah²,

Ayadi³

et al. 2020

Hepatitis a and Other Associated Hepatobiliary Diseases

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“…Hepatitis A is a widespread, highly contagious anthroponotic viral infection caused by the hepatitis A virus (HAV), described by many authors in humans and various species of monkeys …”

Section: Introductionmentioning

confidence: 99%

Molecular genetic identification of isolates of the hepatitis A virus (HAV) from monkeys at Adler Primate Center

Догадов

Korzaya

Karlsen

et al. 2018

J of Medical Primatology

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Seroprevalence of hepatitis A virus infection in Central‐West of Tunisia

Ayouni

Kharroubi

Mallekh

et al. 2020

Journal of Medical Virology

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Hepatitis A infections still represent a major global health concern. During the past years, a transition pattern of the hepatitis A epidemiology was noted in many parts of the world. In Tunisia, there is not a recent survey on age‐specific hepatitis A virus seroprevalence. This study aimed to investigate the seroprevalence of hepatitis A virus infection in Central‐West Tunisia, representative of regions with lowest socioeconomic level in the country, before vaccine implementation. Sera obtained from the blood samples of subjects were screened for the detection of hepatitis A virus. The seroprevalence was evaluated by detection of total antibodies to hepatitis A virus using commercially available immunoassay kits. A total of 1379 subjects, aged 5–75 years (mean age: 29.0 ± 17.3 years) were studied. The global anti‐hepatitis A virus seroplevalence was 84.7% (95% confidence interval: [82.6–86.5]). A higher hepatitis A virus seroprevalence was showed in subjects aged 10–14 years compared to those aged less than 10 years (50.0% vs. 31.0%). In subjects aged 20–29 years, a rapid increase in the hepatitis A virus prevalence was noted; it reached 97.0%. The seroprevalence of anti‐hepatitis A virus differed by zone of residence (81.1% in rural area vs. 72.4% in urban area, p = .005) and increased significantly with lower level of education (p = .019). There was no statistical significant seroprevalence difference between male and female: 84.2% versus 85.2%, respectively. Our study confirm the transition pattern of the hepatitis A virus endemicity in Tunisia from high to intermediate and provide an evaluation of the hepatitis A virus epidemiological situation before vaccine implementation.

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Epidemiological and clinical analysis of hepatitis virus A infections during three successive outbreaks in Sfax (Tunisia) between 2007 and 2010

Cited by 7 publications

References 0 publications

Epidemiological Aspects of Hepatitis A: Endemicity Patterns and Molecular Epidemiology

Epidemiological Aspects of Hepatitis A: Endemicity Patterns and Molecular Epidemiology

Molecular genetic identification of isolates of the hepatitis A virus (HAV) from monkeys at Adler Primate Center

Seroprevalence of hepatitis A virus infection in Central‐West of Tunisia

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