Epidemiological analysis of the spread of pathogens from a urological ward using genotypic, phenotypic and clinical parameters

Wagenlehner, Florian M. E.; Krčmery, S.; Held, Claudia; Klare, Ingo; Witte, Wolfgang; Bauernfeind, A.; Schneider, Ines; Naber, Kurt G.

doi:10.1016/s0924-8579(02)00093-6

Cited by 21 publications

(15 citation statements)

References 20 publications

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“…The pathogens causing NAUTI may come from the patients themselves, from the hospital personnel or neighbouring patients [6]. Significant regional differences have been reported for the susceptibility pattern in community-acquired UTIs [1].…”

Section: Most Important Findingsmentioning

confidence: 99%

“…Little is known about the spectrum and the susceptibility of pathogens in urology departments in an international perspective. Pathogens may spread between patients, and health personnel may act as carriers [6]. Since pathogens do not respect national boundaries, and the transport of patients and health personnel is increasing, we decided to study this on an international level [7].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hospital acquired urinary tract infections in urology departments: pathogens, susceptibility and use of antibiotics

Johansen

Çek

Naber

et al. 2006

International Journal of Antimicrobial Agents

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Section: Most Important Findingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hospital acquired urinary tract infections in urology departments: pathogens, susceptibility and use of antibiotics

Johansen

Çek

Naber

et al. 2006

International Journal of Antimicrobial Agents

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“…The difference was statistically significant (two-tailed Kolmogorov-Smirnov test, P < 0.0001). If the APACHE II scores of all visits with infections are calculated, the highest mean values were registered on the days when bacteraemia was diagnosed (24), followed by gastrointestinal infections (18), pneumonia (17) and UTI (16). In nine of 31 (29%) NUTI episodes, a concomitant infection other than UTI was present.…”

Section: Incidence Of Infectionmentioning

confidence: 99%

Incidence of nosocomial urinary tract infections on a surgical intensive care unit and implications for management

Wagenlehner

Loibl

Vogel

et al. 2006

International Journal of Antimicrobial Agents

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“…Furthermore, the duration of asymptomatic bladder colonization is shorter on average in hospitalized patients than in healthy carriers. Additionally, the hospital environment may preselect certain E. coli vari-ants, e.g., by nosocomial transmission and cross-transmission of strains (58), which may differ in virulence potential and phylogeny from ABU isolates carried by otherwise healthy individuals.…”

mentioning

confidence: 99%

Comparison of Asymptomatic Bacteriuria Escherichia coli Isolates from Healthy Individuals versus Those from Hospital Patients Shows that Long-Term Bladder Colonization Selects for Attenuated Virulence Phenotypes

et al. 2012

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Asymptomatic bacteriuria (ABU) is a condition where bacteria stably colonize the urinary tract, in a manner closely resembling commensalism at other mucosal sites. The patients carry >10 5 CFU/ml for extended periods of time and rarely develop symptoms. Contrasting the properties of ABU strains to those of uropathogenic isolates causing symptomatic infection is therefore highly relevant to understand mechanisms of bacterial adaptation. The prototype ABU strain Escherichia coli 83972 has a smaller genome than uropathogenic E. coli (UPEC) strains with deletions or point mutations in several virulence genes, suggesting that ABU strains undergo a programmed reductive evolution within human hosts. This study addressed if these observations can be generalized. Strains causing ABU in outpatients or hospitalized patients after catheterization or other invasive procedures were compared to commensal E. coli isolates from the intestinal flora of healthy individuals. Notably, clonal complex 73 (CC73) was a prominent phylogenetic lineage dominated by ABU isolates. ABU isolates from outpatients and hospitalized patients had a similar overall virulence gene repertoire, which distinguished them from many commensals, but typical UPEC virulence genes were less frequently attenuated in hospital strains than in outpatient strains or commensals. The decreased virulence potential of outpatient ABU isolates relative to that of ABU strains from hospitalized patients supports the hypothesis that loss of expression or decay of virulence genes facilitates long-term carriage and adaptation to host environments.

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Epidemiological analysis of the spread of pathogens from a urological ward using genotypic, phenotypic and clinical parameters

Cited by 21 publications

References 20 publications

Hospital acquired urinary tract infections in urology departments: pathogens, susceptibility and use of antibiotics

Hospital acquired urinary tract infections in urology departments: pathogens, susceptibility and use of antibiotics

Incidence of nosocomial urinary tract infections on a surgical intensive care unit and implications for management

Comparison of Asymptomatic Bacteriuria Escherichia coli Isolates from Healthy Individuals versus Those from Hospital Patients Shows that Long-Term Bladder Colonization Selects for Attenuated Virulence Phenotypes

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