Epidemiological analysis of strains of methicillin-resistant Staphylococcus aureus (MRSA) infection in the nursery; prognosis of MRSA carrier infants

Mitsuda, Toshihiro; Arai, Kazuji; Fujita, Shujiro; Yokota, Shumpei

doi:10.1016/0195-6701(95)90167-1

Cited by 44 publications

(35 citation statements)

References 20 publications

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“…The duration of MRSA carriage varies between different studies [8][9][10][11][12][13][14][15]. Most studies show longer durations of carriage compared to our study and the existence of household contacts or spa-type are not taken into account.…”

Section: Discussionmentioning

confidence: 72%

See 1 more Smart Citation

Duration of methicillin-resistant Staphylococcus aureus colonization after diagnosis: A four-year experience from southern Sweden

Larsson

Gustafsson²,

Nilsson

et al. 2011

Scandinavian Journal of Infectious Diseases

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Section: Discussionmentioning

confidence: 72%

“…MRSA is also associated with higher healthcare costs [7]. The duration of colonization with MRSA varies widely among studies [8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Duration of methicillin-resistant Staphylococcus aureus colonization after diagnosis: A four-year experience from southern Sweden

Larsson

Gustafsson²,

Nilsson

et al. 2011

Scandinavian Journal of Infectious Diseases

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“…6,7 Molecular typing of MRSA isolates (N = 12) obtained from four inpatient children, their mothers, and from four HCWs in ICU was performed by pulsed field gel electrophoresis (PFGE) as previously reported. 8 The MRSA isolates were tested for resistance to antimicrobials by the disc diffusion method recommended by the Clinical Laboratory Standards Institute. 9 The following antimicrobial discs were used: ciprofloxacin (5 μg), clindamycin (2 μg), pristinamycin (15 μg), erythromycin (15 μg), gentamicin (10 μg), fusidic acid (10 μg), mupirocin (20 μg), trimethoprim-sulfamethoxazole (25 μg), and vancomycin (30 μg) (Oxoid, Basingstoke, Hampshire, UK).…”

Section: Methodsmentioning

confidence: 99%

Nasal Carriage of Multi-Drug Resistant Panton-Valentine Leucocidin-Positive Methicillin-Resistant Staphylococcus aureus in Children in Tripoli-Libya

Al-haddad

Zorgani

Ghenghesh

2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Methicillin-resistant Staphylococcus aureus (MRSA) colonized children are at an increased risk of developing infections than methicillin-sensitive S. aureus colonized children. Nasal specimens from inpatient children, mothers of inpatient children, healthcare workers, and outpatient children at Tripoli Children Hospital (TCH) were examined for MRSA by chromogenic MRSA ID medium. Susceptibility of MRSA isolates to antibiotics was determined by the disc diffusion method. The nasal carriage rate of MRSA among inpatient children (8.3%, 24 of 289), their mothers (11%, 22 of 200), and healthcare workers (12.4%, 22 of 178) was significantly higher than among outpatient children (2.2%, 2 of 91) (P 0.05, P 0.02, and P 0.006, respectively). Of the examined MRSA isolates (N = 35) 10 (28.6%) were positive for Panton-Valentine leucocidin genes by polymerase chain reaction. Multidrug resistance was found in 24.3% (17 of 70) of MRSA isolates. Nasal carriage of multidrug-resistant Panton-Valentine leucocidin-positive MRSA is not uncommon among inpatient children and their mothers in Tripoli.

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“…Moreover, MRSA carriers play an important role in spreading MRSA to their family members and community contacts [4][5][6] , resulting in the in-hospital spread of MRSA at the time of readmission [7][8][9] . In addition, an increasing number of neonates colonized with MRSA are discharged from nurseries [10] and neonatal intensive care units (NICUs). Thus, obtaining better knowledge of MRSA colonization is important…”

mentioning

confidence: 99%

Clinical Outcomes in Methicillin-Resistant <i>Staphylococcus aureus-</i>Colonized Neonates in the Neonatal Intensive Care Unit

Kim

Chang²,

Kim³

et al. 2006

Neonatology

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Background: Methicillin-resistent Staphylococcus aureus (MRSA) colonization can persist for prolonged periods, and patient-related factors are associated with persistent carriage in adults. However, such knowledge is lacking among neonates. Objectives: To better understand the outcome of MRSA-colonized neonates in the neonatal intensive care unit (NICU), we prospectively followed all colonized neonates until decolonization over 39 months and determined the incidence, duration of colonization, clinical outcomes and risk factors associated with prolonged carriage of MRSA. Methods: Nasal and inguinal cultures were obtained from all newly admitted neonates following an outbreak of MRSA. Weekly and 1–2 monthly cultures were obtained from all hospitalized and discharged neonates colonized with MRSA, respectively, until 2 consecutive cultures were negative. Results: 152 of 1,456 (10.4%) neonates became colonized. The mean time to acquire MRSA colonization was 17.1 ± 40.7 (range 1–471) days. The median time to decolonization was 36 days. About 20% of decolonized patients had been colonized for a prolonged period of ≧160 days. 47.5% of colonized patients were sent home colonized, and none with prolonged carriage developed MRSA-related infections in the following 6 months in contrast to 6 infants (3.9%) who developed MRSA sepsis during hospitalization. The only risk factor associated with prolonged carriage was the concurrent colonization of both the inguinal and nasal areas on admission. Conclusion:Nearly all neonates with acquired colonization became decolonized either prior to or after discharge from NICU. A significant percentage failed to decolonize prior to hospital discharge, but almost all decolonized by 30 months in the community without evidence of systemic or local infections.

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Epidemiological analysis of strains of methicillin-resistant Staphylococcus aureus (MRSA) infection in the nursery; prognosis of MRSA carrier infants

Cited by 44 publications

References 20 publications

Duration of methicillin-resistant Staphylococcus aureus colonization after diagnosis: A four-year experience from southern Sweden

Duration of methicillin-resistant Staphylococcus aureus colonization after diagnosis: A four-year experience from southern Sweden

Nasal Carriage of Multi-Drug Resistant Panton-Valentine Leucocidin-Positive Methicillin-Resistant Staphylococcus aureus in Children in Tripoli-Libya

Clinical Outcomes in Methicillin-Resistant <i>Staphylococcus aureus-</i>Colonized Neonates in the Neonatal Intensive Care Unit

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