Epidemiological analysis of risk factors for breast cancer in Indonesian females

Budiningsih, Setyawati; Ohno, Yoshiyuki; Prihartono, Joedo; Ramli, Muchlis; Wakai, Kenji; Cornain, Santoso; Darwis, Idral; Suzuki, Sadao; Tjindarbumi, Didid; Watanabe, Susumu; Tjahjadi, Gunawan; Sakamoto, Goi; Soetrisno, Esti; Roostini, Endang S.

doi:10.13181/mji.v4i3.913

Cited by 7 publications

(4 citation statements)

References 11 publications

(1 reference statement)

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“…Although Southeast Asian countries are experiencing a substantial increase in the burden of breast cancer, there have been limited studies in risk factors for breast cancer in these populations. Before the Malaysian Breast Cancer Genetic study, the previous largest study on breast cancer risk factors in Southeast Asia was from Indonesia and included 526 cases and 1,052 controls [ 17 , 18 ]. A large scale prospective cohort study that followed 35,303 women in which 629 developed breast cancer has been conducted in Singapore, however, it focused mainly on soy intake and breast cancer risk and was limited to Chinese only [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

A case-control study of breast cancer risk factors in 7,663 women in Malaysia

Tan

Yoon

et al. 2018

PLoS ONE

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BackgroundBreast cancer risk factors have been examined extensively in Western setting and more developed Asian cities/countries. However, there are limited data on developing Asian countries. The purpose of this study was to examine breast cancer risk factors and the change of selected risk factors across birth cohorts in Malaysian women.MethodsAn unmatched hospital based case-control study was conducted from October 2002 to December 2016 in Selangor, Malaysia. A total of 3,683 cases and 3,980 controls were included in this study. Unconditional logistic regressions, adjusted for potential confounding factors, were conducted. The breast cancer risk factors were compared across four birth cohorts by ethnicity.ResultsEver breastfed, longer breastfeeding duration, a higher soymilk and soy product intake, and a higher level of physical activity were associated with lower risk of breast cancer. Chinese had the lowest breastfeeding rate, shortest breastfeeding duration, lowest parity and highest age of first full term pregnancy.ConclusionsOur study shows that breastfeeding, soy intake and physical activity are modifiable risk factors for breast cancer. With the increasing incidence of breast cancer there is an urgent need to educate the women about lifestyle intervention they can take to reduce their breast cancer risk.

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Section: Discussionmentioning

confidence: 99%

A case-control study of breast cancer risk factors in 7,663 women in Malaysia

Tan

Yoon

et al. 2018

PLoS ONE

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“…Trauma has been considered as risk factor, since 9Vo of breast cancer patients had breast trauma experience and only ZVo in the control group. 8,9 Earlier studies repofted that genetic trait was a significant risk factor. Female …”

Section: Introductionmentioning

confidence: 99%

Comparative study of the two-period of epidemiological analysis of risk factors for breast cancer in Indonesia. Does it change?

et al. 1999

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AbstrakPenelitian kasus kontrol kanker payudara dalam aspek epidemiologi, khuswnya tentang faktor risiko telah dun kali dilakukan di Indonesia. Pertama kali daLam tahun [1980][1981] In the second study, performed under the International Collaborative Study on Breast Cancer betyveen Indonesia and Japan (University of lwlonesiafrom Indonesia and Nagoya University and Cancer Institute Tokyofrom Japan), 300 cases ofbreast cancer were compared to 600 matched controls. [n comparative analysis between the two studies, the following findings were obtained. It was estimated that there wàs no chnnge of age distribution of breast cance4 which peaked at the ege group of 40-49. There was no significant chnnge of the stage distribution of breast cance4 although early detection program pioneered by Indonesia Cancer Foundation had been caruied out since twenty years ago. Tën years dffirence was seen betvveen the first study and the second study, while the distribution of cases according to edtrcation did not chnnge significantly. The result of risk factor analysis showed that only irradiation and history of trauma increased the risk of breast cancer significantly in the first study, while obese, marital status, illiterate, pregnancy and lactation did not cause significant dffirence. In the second study, it was found that marriage and irradiation had protective effect in the development of breast cancer; while separated, widowed status, illiterate, pregnancy, lactation and trauma were found as significant riskfactors in breast cancer development.

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“…Nulliparity can increase the risk of developing breast cancer due to longer exposure to the hormone estrogen. High levels of the hormone estrogen during a woman's reproductive period, especially if not accompanied by hormonal changes (in pregnancy and breastfeeding) increase the chances of growing cells that are genetically damaged and cause cancer [15]. Nulliparous women have a 4.0 times greater risk of developing breast cancer than multiparous women [8], [15].…”

Section: Discussionmentioning

confidence: 99%

“…High levels of the hormone estrogen during a woman's reproductive period, especially if not accompanied by hormonal changes (in pregnancy and breastfeeding) increase the chances of growing cells that are genetically damaged and cause cancer [15]. Nulliparous women have a 4.0 times greater risk of developing breast cancer than multiparous women [8], [15]. Nulliparous women have a higher risk because these women have never breastfed.…”

Section: Discussionmentioning

confidence: 99%

Reproductive Determinants of Breast Cancer in Women in Indonesia

Sukma

Effendi²,

Harahap³

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: The number of breast cancer cases has increased every year both in the world and in Indonesia, so that breast cancer has become a major health problem both in the world and in Indonesia. The specific cause of breast cancer is still not known with certainty, but many factors are thought to influence the development of breast cancer which are called risk factors. In women, reproductive factors are thought to influence the incidence of breast cancer. AIM: This study aims to determine the determinants of breast cancer in women in terms of reproductive factors. METHOD: This research is a quantitative research with a case control study design through a retrospective approach using a questionnaire instrument. The sample size obtained was 100 women with breast cancer (case sample) and 100 women without breast cancer (control sample) (1:1), so the total sample was 200 people. Data were analyzed bivariately using chi-square test, and multivariate using logistic regression test. RESULTS: From this study it is known that the reproductive factor associated with the incidence of breast cancer in women is the age of menarche with a value of p = 0.034 OR = 1.83 CI = 1.045-3.207, the age of giving birth to the first child with a value of p = 0.000 OR = 6.39 CI = 2,521-16,243, parity with p-value = 0.022 OR = 2.14 CI = 1.107-4.152, and history of breastfeeding with p-value = 0.000 OR = 4.16 CI = 1.967-8.830. Meanwhile, the age of menopause had no relationship with the incidence of breast cancer where the p-value was 0.384. Based on the results of multivariate analysis, it was found that the most dominant factor was the age at birth of the first child with a value of p = 0.002, Exp (B) = 5, 11 and CI = 1, 85-14, 10. CONCLUSION: The results of this study indicate that reproductive factors in women (age of menarche, age at first birth, parity, and history of breastfeeding) are risk factors for breast cancer. Based on the results of this study, women must get married immediately if they have entered the ideal age for marriage and do not delay having children so that they can immediately carry out the breastfeeding process to minimize risk factors to avoid breast cancer.

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Epidemiological analysis of risk factors for breast cancer in Indonesian females

Cited by 7 publications

References 11 publications

A case-control study of breast cancer risk factors in 7,663 women in Malaysia

A case-control study of breast cancer risk factors in 7,663 women in Malaysia

Comparative study of the two-period of epidemiological analysis of risk factors for breast cancer in Indonesia. Does it change?

Reproductive Determinants of Breast Cancer in Women in Indonesia

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