Epidemiological analysis of mosquito-borne Pogosta disease in Finland, 2009

Sane, Jussi; Guedes, Sandra; Kurkela, Satu; Lyytikäinen, Outi; Vapalahti, Olli

doi:10.2807/ese.15.02.19462-en

Cited by 26 publications

(19 citation statements)

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“…Similarly, SINV infections have increased in Finland since the 1970s [2,9,17] and it could also be the case for neighbouring Sweden. The present study was motivated by the lack of current information concerning SINV infection in Sweden and a possible involvement in jointrelated illnesses, which constitutes a common public health problem.…”

Section: Introductionmentioning

confidence: 93%

Seroprevalence of Sindbis virus and associated risk factors in northern Sweden

et al. 2013

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SUMMARYMosquito-borne Sindbis virus (SINV) cause disease characterized by rash, fever and arthritis which often leads to long-lasting arthralgia. To determine the seroprevalence of SINV and associated risk factors in northern Sweden, a randomly selected population aged between 25 and 74 years were invited to join the MONICA study. Serum from 1611 samples were analysed for specific IgG antibodies. Overall, 2·9% had IgG against SINV. More men (3·7%) than women (2·0%) were SINV seropositive (P = 0·047) and it was more common in subjects with a lower educational level (P = 0·013) and living in small, rural communities (P < 0·001). Seropositivity was associated with higher waist circumference (P = 0·1), elevated diastolic blood pressure (P = 0·037), and history of a previous stroke (P = 0·011). In a multiple logistic regression analysis, adjusting for known risk factors for stroke, seropositivity for SINV was an independent predictor of having had a stroke (odds ratio 4·3, 95% confidence interval 1·4-13·0, P = 0·011).

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Section: Introductionmentioning

confidence: 93%

Seroprevalence of Sindbis virus and associated risk factors in northern Sweden

et al. 2013

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“…SINV is arthropod-borne and is maintained in nature by transmission between vertebrate (bird) hosts and invertebrate (mosquito) vectors (Strauss and Strauss, 1994). In humans, SINV infection is widespread in the Old World and can cause chronic polyarthritis and Pogosta disease (Kurkela et al, 2005; Sane et al, 2010). Many additional alphaviruses infect humans and can cause severe illnesses and are thus considered serious human pathogens, including Chikungunya virus, Ross River virus, and Venezuelan Equine Encephalitis virus (Griffin, 2007; Weaver and Barrett, 2004).…”

Section: Virusesmentioning

confidence: 99%

Viruses and antiviral immunity in Drosophila

Cherry

2014

Developmental & Comparative Immunology

126

123

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Viral pathogens present many challenges to organisms, driving the evolution of a myriad of antiviral strategies to combat infections. A wide variety of viruses infect invertebrates, including both natural pathogens that are insect-restricted, and viruses that are transmitted to vertebrates. Studies using the powerful tools available in the model organism Drosophila have expanded our understanding of antiviral defenses against diverse viruses. In this review, we will cover three major areas. First, we will describe the tools used to study viruses in Drosophila. Second, we will survey the major viruses that have been studied in Drosophila. And lastly, we will discuss the well-characterized mechanisms that are active against these diverse pathogens, focusing on non-RNAi mediated antiviral mechanisms. Antiviral RNAi is discussed in another paper in this issue.

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“…In 1981 Sweden reported 54 cases (Ockelbo), Russia 200 cases (Karelian) and Finland 300 cases (Pogosta) of clinically and serologically diagnosed SINV infection (Brummer-Korvenkontio et al, 2002;Espmark & Niklasson, 1984;L'Vov D et al, 1982). Outbreaks of Pogosta disease have thus far emerged every seven years since the first outbreak was noted in 1974, including a large outbreak in 2002 (Sane et al, 2010).…”

Section: Sindbis Virus (Sinv)mentioning

confidence: 99%