Epidemiological Analysis of Lymphoma Subtypes in a Reference Center in João Pessoa

Caminha, Bruno Leão; Vieira, Gabrielle Hyllen Neves Rodrigues; Pimenta, Marcelle Bragante Fernandes; Albuquerque, Tarsyla Medeiros de; Pimenta, Martina Bragante Fernandes; Albuquerque, Mácio Augusto de; Tavares, Nathalia de Alencar Cunha; Cruz, Lafayette Cavalcante Bezerra Dias; Pimenta, Flávia Cristina Fernandes

doi:10.4172/2155-9554.1000473

Cited by 4 publications

(6 citation statements)

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“…The youngest of these patients was four years old and the oldest 80 years old, with a mean age of 41 years. These results were consistent with Caminha et al study [33].…”

Section: Discussionsupporting

confidence: 93%

Relative Frequencies and Patterns of Malignant Lymphoma in a Reference Centre in Khartoum, Sudan: A Descriptive Study Based on the WHO Classification of Lymphoid Neoplasms

Abdalhabib¹

2020

Asian Pac J Cancer Care

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Background: The effective management and choice of appropriate treatment of lymphoma subtypes depend on an accurate diagnosis and differentiation, which require comprehensive haematology and pathology work. Methods: A total of 134 cases of malignant lymphoma, newly diagnosed between January 2017 to January 2020, were selected. For each patient’s samples, complete blood count, immunohistochemistry, and morphological evaluation were done. Results: Clinical data showed that 81 patients (60.4%) were males and 53 (39.6%) females. The age range was 4 to 80 years. NHL lymphoma comprised 87.3% of cases, while HL comprised 12.7% of cases. Diffuse large B cell lymphoma was the most prevalent NHL subtype, representing 39.3% of cases. Among HL subtypes, mixed cellularity was present in 41.2% of cases. B cell lymphoma constituted 93.2% of cases. All HL patients and 74.4% of NHL patients had anaemia. Conclusion: This is the first statistical report of malignant lymphoma patterns in Sudanese patients. These data suggest that malignant lymphoma in Sudanese patients is more frequent in males than females; its incidence increases with age. Further, B cell lymphoma is more common than T cell lymphoma. Diffuse large B cell lymphoma was the most frequent NHL subtype.

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“…The youngest of these patients was four years old and the oldest 80 years old, with a mean age of 41 years. These results were consistent with Caminha et al study [33].…”

Section: Discussionsupporting

confidence: 93%

Relative Frequencies and Patterns of Malignant Lymphoma in a Reference Centre in Khartoum, Sudan: A Descriptive Study Based on the WHO Classification of Lymphoid Neoplasms

Abdalhabib¹

2020

Asian Pac J Cancer Care

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“…Nodular lymphocyte predominant was the most dominant histologic subtype, accounting for 63.6% of cases, this correlates with findings in Maiduguri, North-East Nigeria, where Nodular lymphocyte predominant was equally the dominant histological subtype [44]. The finding is however at variance with the general observation in most studies in which nodular sclerosis is catalogued as the most prevalent subtype [25,26,30,33,45,46]. Nodular sclerosis made up 18.2% of HL seen in this study.…”

Section: Stagesupporting

confidence: 84%

“…This is comparable to 80% observed in Maiduguri [44], though much higher than 57.1% obtained in Kano [51] and lower than 93% reported in a study in Gabon [52]. A predominance of NHL has equally been observed in other studies [42,46]. Small lymphocytic lymphoma formed the vast majority of the NHL cases encountered in our study.…”

Section: Stagesupporting

confidence: 80%

“…No cases of mixed cellularity subtype of HL were seen in the present study. In contrast, mixed cellularity HL constituted 64.3% and 14.7% of HL in Benin [48] and Brazil respectively [46]. Non-Hodgkin lymphoma made up 81.4% of cases seen in the current review.…”

Section: Stagementioning

confidence: 75%

“…The para-aortic nodes, omentum and peritoneum were the least common sites of lymphoma in the present study accounting for 3.6% of cases. However, several studies [41][42][43][44][45][46] have shown cervical lymph nodes to be the commonest nodal site of lymphoma, followed by the axillary nodes and other lymph nodes. The predominance of cervical lymph nodes in the aforementioned studies might be due to the fact that this group of lymph nodes provide ease of access compared to axillary, mesenteric, epitrochlear, supraclavicalar and inguinal lymph nodes.…”

Section: Stagementioning

confidence: 99%

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Adult Lymphomas in a Tertiary Hospital in South – South Nigeria: A Review of Clinicopathologic Features and Treatment Outcome

Akpan

Tanimowo

Bassey

et al. 2021

IBRR

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Background: There has been an increase in the prevalence of Lymphomas in our environment lately. Thorough literature search reveals a limited number of reports on the prevalence of Lymphoma and no information on the clinicopathologic pattern and outcome of treatment of this disease in our centre. Data on the burden of Lymphoma across different regions are important, as there may be variation in incidence in different locations even within the same country. This will keep healthcare providers informed about the current trend of Lymphomas in the region and facilitate prompt and appropriate diagnosis and treatment as well as assist Government agencies in better healthcare planning. Aim: To determine the burden, clinicopathologic characteristics and treatment outcome of Lymphoma among a cohort of adult patients accessing care in a Referral Hospital in Southern Nigeria Methods: This was a longitudinal prospective study of all lymphoma cases managed in the Department of Haematology, University of Uyo Teaching Hospital, Uyo, between January 1, 2014 and December 31, 2018 Results: There were 59 cases. Forty 40 (67.8%) were males and 19(32.2%)were females giving a male to female ratio of 4.4:1. Hodgkin Lymphoma(HL) accounted for 11(18.6%) of the cases while Non-Hodgkin Lymphoma(NHL) accounted for 48( 81.4%)of the cases , with the mean ages for HL and NHL patients being 32.09 +9.22 years and 40.88 + 12.21 years, respectively. The distribution of the different histologic subtypes of the malignancy were as follows: HL; Nodular Lymphocyte Predominant(7cases;63.6%), Nodular Sclerosis(2 cases;18.2%) and Lymphocyte Depleted(2 cases;18.2%). NHL; Small Lymphocytic Lymphoma(23cases;47.9%),Diffuse Large Cell Lymphoma(15 cases;31.3%),unspecified (4 cases;8.3%), Follicular Lymphoma(2 cases;4.2%),Lymphoblastic Lymphoma(2 cases;4.2%), Mantle Cell Lymphoma(1 case;2.1%) and Adult T-Cell Lymphoma(1 case;2.1%). Fourteen 14 (29.2%) out of all the NHL patients had immunohistochemistry and only nine 9 of them were CD20 positive. Relapse rate among the cohort was 11.9% (7/59), while 15.3% (9/59) were still in remission. The cure rate was 5.1%, loss to follow up was 22.0% and 37.3% of patients died in the course of therapy either from advanced disease, non -compliance to treatment or late presentation. All the HL patients received ABVD (Adriamycin, Bleomycin, Vinblastine and Dacarbazine) regimen alone. Majority of the NHL patients (91.7%, 44/48) received CHOP (Cyclophosphamide, Doxorubicin, Oncovin and Prednisolone) regimen alone, while 8.3% (4/48) received Rituximab with CHOP (R-CHOP). Conclusion: The clinicopathological profile, age and sex distribution of lymphoma in our study were comparable to those reported by other authors with nodular lymphocyte predominant being the most common HL histologic subtype and small lymphocytic lymphoma the predominant NHL histologic subtype in our environment. The general outcome was very poor with a high default rate and unsettling mortality figures.

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Epidemiology and etiology of diffuse large B-cell lymphoma

Wang

2023

Seminars in Hematology

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Epidemiological Analysis of Lymphoma Subtypes in a Reference Center in João Pessoa

Cited by 4 publications

References 0 publications

Relative Frequencies and Patterns of Malignant Lymphoma in a Reference Centre in Khartoum, Sudan: A Descriptive Study Based on the WHO Classification of Lymphoid Neoplasms

Relative Frequencies and Patterns of Malignant Lymphoma in a Reference Centre in Khartoum, Sudan: A Descriptive Study Based on the WHO Classification of Lymphoid Neoplasms

Adult Lymphomas in a Tertiary Hospital in South – South Nigeria: A Review of Clinicopathologic Features and Treatment Outcome

Epidemiology and etiology of diffuse large B-cell lymphoma

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