Epidemiological analysis of dyslipidemia in adults of three ethnicities in Xinjiang, China

Guo, Shuxia; Ma, Rulin; Guo, Huiling; Ding, Yaobin; Liu, J.M.; Zhang, M.; Zhang, J.Y.; Xu, Shangzhi; Li, S.G.; Rui, Dongsheng; Niu, Qiang; Li, Y.P.

doi:10.4238/2014.april.3.11

Cited by 11 publications

(12 citation statements)

References 20 publications

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“…Second, urban participants had the highest prevalence of dyslipidemia compared with farmer and nomads groups, and this trend did not change following an increased age. Unlike some other studies showing that the prevalence of dyslipidemia in adult men changed with age like a "∩" shape [23][24][25], our results showed that young men possessed the highest prevalence of dyslipidemia and decreased significantly thereafter. For urban men, for example, the prevalence of dyslipidemia was 59.1% at age 30-44 years, 52.2% at age 45-59 years, and 33.3% at age ≥ 60 years.…”

Section: Epidemic Of Cardiovascular Risk Factorscontrasting

confidence: 99%

“…With increasing age and reduced social interaction, awareness to protect one's health increases, leading to the reduction of dyslipidemia risk. For women, our results revealed a similar trend with other studies [23][24][25]. The prevalence of dyslipidemia in women initially decreased and subsequently increased, this trend might be closely related to changes in hormone levels [26].…”

Section: Epidemic Of Cardiovascular Risk Factorssupporting

confidence: 90%

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Cardiovascular Risk Factors and its Transition: An Ongoing Cohort Study in Chinese Kazakhs

Jiang¹,

Zhang²,

Hou³

et al. 2017

Recent Trends in Cardiovascular Risks

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Studies on the prevalence of risk factors and the incidence for cardiovascular diseases (CVDs) are limited in Kazakh population. By incorporating nomads, farmers, and urban residents, aged 30 years or older, in a cohort study, we investigated the characteristics of cardiovascular risk factors and their temporal trends that arose from the urbanization and subsequent changes in the lifestyle in a Kazakh population with 1668 participants. We used current guidelines and the monitoring trends and determinants in cardiovascular disease (MONICA) standard to define cardiovascular events. Kazakhs had a high prevalence rate of hypertension (45.3%), and this prevalence was much higher than the national average in China. Prevalence of two or more risk factors was highest among urban people and lowest among nomads. Urban residents have the highest prevalence of hypercholesterolemia and obesity compared with farmers and nomads. However, unlike other studies, our data indicate that young men had the highest prevalence of dyslipidemia, and it decreased significantly thereafter. Crude rates of incidence and mortality for acute cardiovascular events were 742 and 194 per 100,000 people, respectively; the standardized rates were 926 and 272 per 100,000 people, respectively. The findings from this study demonstrate the pervasive burden of cardiovascular risk factors and the related acute cardiovascular events in Kazakhs, particularly BP in Kazakh nomads.

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Section: Epidemic Of Cardiovascular Risk Factorscontrasting

confidence: 99%

Section: Epidemic Of Cardiovascular Risk Factorssupporting

confidence: 90%

Cardiovascular Risk Factors and its Transition: An Ongoing Cohort Study in Chinese Kazakhs

Jiang¹,

Zhang²,

Hou³

et al. 2017

Recent Trends in Cardiovascular Risks

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show abstract

“…Dyslipidemia is associated with serious medical conditions such as coronary artery disease (CAD), hypertension, and stroke (Yin et al, 2011). Pilot data showed that dyslipidemia prevalence was 31.8% in the Kazak nationality, which was higher than that in the Uygur nationality (42.4%) (Guo et al, 2014). The prevalence of disease in Kazaks was significantly higher than in adults (> 18 years old) in eleven cities and provinces in China (18.6%) (Zhao et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Association of APOA1 gene polymorphisms (rs670, rs5069, and rs2070665) with dyslipidemia in the Kazakhs of Xinjiang

et al. 2016

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to investigate the potential association between apolipoprotein A1 (APOA1) gene rs670, rs5069, and rs2070665 polymorphisms and dyslipidemia in the Kazakh population of Xinjiang, China. Matrix-assisted laser desorption/ ionization time of flight mass spectrometry (MALDI-TOF-MS) was used to identify APOA1 (rs670, rs5069, and rs2070665) genotypes in 736 subjects (341 dyslipidemia patients and 395 control subjects). The frequencies of the CC genotype for rs1421085 were found to be 7.2% (obese group), 4.4% (overweight group), and 5.6% (control group). Polymorphisms of the three loci of the APOA1 gene in Kazakh subjects met Hardy-Weinberg equilibrium. The frequencies of the A allele for rs670 were found to be 14.3% (dyslipidemia group) and 12.7% (control group). The frequencies of the T allele for rs5069 and rs2070665 were: dyslipidemia group (7.2 and 30.1%, respectively) and control group (7.7 and 32.5%, respectively). Frequency distributions of the 3 types of genotypes and alleles of the three loci showed no statistically significant difference (P > 0.05). Significant differences were observed in lipoprotein (α) [Lp(α)] between patients with the rs2070665 CT + TT and CC genotypes (P < 0.05); however, none of the other relevant indicators differed significantly between the two genotypes. No significant association was identified between rs670 or rs5069 and the lipid-related metabolic indices assessed in the study. These findings indicate that the polymorphisms in the APOA1 gene (rs670, rs5069, and rs2070665) are not associated with dyslipidemia in the Kazakh population assessed in this study.

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“…Dyslipidemia has become one of the most serious public health problems in the world because of its high prevalence [ 1 , 2 ] and a causal relationship of conditions such as coronary artery disease (CAD) [ 3 ], obesity and metabolic syndrome [ 4 ]. Low high-density lipoprotein-cholesterol (HDL-C) as one of the important phenotype of dyslipidemia and it shows higher prevalence than other three kinds of components in dyslipidemia [ 5 , 6 ]. Low HDL-C damage to health is mainly concentrated in the cardiovascular system.…”

Section: Introductionmentioning

confidence: 99%

Interactions of Six SNPs in ABCA1gene and Obesity in Low HDL-C Disease in Kazakh of China

Yao

Guo

et al. 2016

IJERPH

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Objective: To detect the interactions between six functional polymorphisms in ABCA1 and obesity in Kazakhs with low HDL-C levels. Methods: A total of 204 patients with low HDL-C and 207 health control subjects, which were randomly selected from among 5692 adult Kazakhs, were matched for age and sex. We genotyped ABCA1 single nucleotide polymorphisms of rs2515602, rs3890182, rs2275542, rs2230806, rs1800976, and rs4149313. Results: (1) The genotypic and allelic frequencies of rs2515602, rs2230806 and rs4149313 were different between normal HDL-C and low HDL-C subjects, the genotypic frequency of rs2275542 was also different between normal HDL-C and low HDL-C subjects (p < 0.05); (2) the level of HDL-C (rs2515602 and rs2275542) in normal HDL-C subjects were different among the genotypes (p < 0.05); the levels of TC, LDL-C (rs2515602, rs4149313); TG (rs2515602, rs1800976, rs4149313) in low HDL-C patients were different among the genotypes (p < 0.05); (3) interactions between the rs3890182, rs2275542, rs180096, and rs4149313 polymorphisms in ABCA1 gene and obesity may be associated with low HDL-C disease; (4) the C-C-C-A-A-G, T-C-C-A-A-A, T-C-C-A-A-G, C-C-C-A-A-A, C-T-G-G-A-A, and T-T-C-G-A-A haplotypes were significant between the subjects with normal HDL-C and low HDL-C level (p < 0.05). Conclusions: The differences in serum lipid levels between normal HDL-C and low HDL-C subjects among Kazakhs might partly result from ABCA1 gene polymorphisms; ABCA1 gene polymorphisms may be associated with low HDL-C disease; the low HDL-C disease might partly result from interactions between ABCA1 gene polymorphisms and obesity; the C-C-C-A-A-G, T-C-C-A-A-A, and T-C-C-A-A-G haplotypes may serve as risk factors of low HDL-C disease among Kazakhs, the C-C-C-A-A-A, C-T-G-G-A-A, and T-T-C-G-A-A haplotypes may serve as protective factor of low HDL-C disease among Kazakhs.

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Epidemiological analysis of dyslipidemia in adults of three ethnicities in Xinjiang, China

Cited by 11 publications

References 20 publications

Cardiovascular Risk Factors and its Transition: An Ongoing Cohort Study in Chinese Kazakhs

Cardiovascular Risk Factors and its Transition: An Ongoing Cohort Study in Chinese Kazakhs

Association of APOA1 gene polymorphisms (rs670, rs5069, and rs2070665) with dyslipidemia in the Kazakhs of Xinjiang

Interactions of Six SNPs in ABCA1gene and Obesity in Low HDL-C Disease in Kazakh of China

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