Epidemiological Analysis of Antimicrobial Resistance in <i>Staphylococcus epidermidis</i> in Scotland, 2014–2018

Zalewska, Adriana; Wilson, Julie; Kennedy, Sharon; Lockhart, Michael; Macleod, Mairi; Malcolm, William

doi:10.1089/mdr.2019.0502

Cited by 3 publications

(2 citation statements)

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“…According to the study of Høiby et al ( 1997 ), extensive use of quinolone antibiotics and continuous excretion from sweat into the skin can increase the resistance of Staphylococcus epidermidis to quinolone antibiotics, and the increased resistance rates to levofloxacin and ciprofloxacin in this study may be related to this mechanism. Previous studies have shown that rifampicin-resistant Staphylococcus epidermidis strains are more likely to develop resistance to a variety of other antibiotics, and certain rpoB mutant strains have been shown to have heterogeneous resistance to vancomycin (Zalewska et al, 2021 ). In this study, no significant change was showed in the resistance rate of Staphylococcus epidermidis to rifampicin in the past 8 years.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, no significant change was showed in the resistance rate of Staphylococcus epidermidis to rifampicin in the past 8 years. However, it should be noticed that the resistance rate to rifampicin reached 10.2% in 2021, higher than the national level (8.7%) and the level of some regions in Europe (8.9%) (Zalewska et al, 2021 ; Hu Fupin et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

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Analysis of distribution and antibiotic resistance of Gram-positive bacteria isolated from a tertiary-care hospital in southern China: an 8-year retrospective study

Zhang,

Tan,

Ouyang

et al. 2023

Front. Microbiol.

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ObjectiveDue to the severe drug resistance situation of Gram-negative bacteria, especially Gram-negative enterobacter, relatively little attention has been paid to the changes in Gram-positive bacteria species and drug resistance. Therefore, this study analyzed the prevalence and drug resistance of Gram-positive bacteria in a general tertiary-care hospital from 2014 to 2021, in order to discover the changes in Gram-positive bacteria distribution and drug resistance that cannot be easily identified, inform clinicians in their respective regions when selecting antimicrobial agents, and to provide the basis for the diagnosis of Gram-positive bacterial infection, and for the comprehensive and multi-pronged prevention and control of drug-resistant bacteria.MethodsA retrospective study was conducted on Gram-positive bacteria isolated from patients presented to a general tertiary-care hospital from January 2014 to December 2021. A total of 15,217 Gram-positive strains were analyzed.ResultsDuring the 8-year period, the total number and the species of Gram-positive bacteria isolated from clinic increased continuously. The seven most common species were Streptococcus pneumoniae (21.2%), Staphylococcus aureus (15.9%), Enterococcus faecium (20.6%), Enterococcus faecalis (14.0%), and Staphylococcus epidermidis (7.8%), Staphylococcus haemolyticus (4.8%), Streptococcus agalactiae (3.6%). The isolation rates of Staphylococcus aureus and Streptococcus agalactiae increased, and the isolation rate of Enterococcus faecium decreased. The resistance rates of Staphylococcus aureus to erythromycin, clindamycin, tetracycline, rifampicin and furantoin decreased obviously. The resistance rates of Streptococcus pneumoniae to cefepime (non-meningitis) and ceftriaxone (meningitis) decreased significantly. The resistance rates of Enterococcus faecium to penicillin, ampicillin, erythromycin, levofloxacin, ciprofloxacin and furantoin rose rapidly from 50.3, 47.6, 71.5, 44.9, 52.3, and 37.5% in 2014 to 93.1, 91.6, 84.9, 86.8, 86.8, and 60.0% in 2021, respectively.ConclusionThe total number and the species of Gram-positive bacteria isolated during the 8-year period increased continuously. Streptococcus pneumoniae and Staphylococcus aureus are the main causes of positive bacterial infections in this hospital. The resistance rates of Enterococcus faecium to a variety of commonly used antibiotics increased significantly. Therefore, it is very important to monitor the distribution of bacteria and their resistance to antibiotics to timely evaluate and identify changes in drug resistance that are not easily detected.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Analysis of distribution and antibiotic resistance of Gram-positive bacteria isolated from a tertiary-care hospital in southern China: an 8-year retrospective study

Zhang,

Tan,

Ouyang

et al. 2023

Front. Microbiol.

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Antibiotic therapy and awareness of antibiotic resistance problem in medical practice

et al. 2021

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Identification and analysis of CRISPR/Cas systems structures in the genomes of antibiotic-resistant strains of <i>Klebsiella pneumoniae</i>

Stepanenko,

Sukhov,

Kon’kova

et al. 2024

Acta biomedica scientifica

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Background. Klebsiella pneumoniae belongs to a group of opportunistic bacteria that can form multiple resistance to antibiotics and transmit it to various types of bacteria through horizontal gene transfer. These studies examine the structural and functional diversity of CRISPR/Cas systems that protect bacteria from foreign DNA. Their analysis using the example of antibiotic-resistant strains of Klebsiella pneumoniae will demonstrate their resistance to certain bacteriophages, which will make it possible to develop approaches to the treatment of complex infectious diseases caused by these microorganisms by creating targeted phage therapy.The aim. To perform a bioinformatics analysis of the identified structural components of CRISPR/Cas systems for screening bacteriophages through CRISPR cassette spacers using the example of antibiotic-resistant strains of Klebsiella pneumoniae.Materials and methods. The article analyzed 29 full-genome sequences of Klebsiella pneumoniae, in the genome of which the structures of CRISPR/Cas systems and antibiotic resistance genes were determined (according to NCBI). To achieve this goal, using software modeling methods, a search was made for Cas genes and CRISPR cassettes, and their structural and functional characteristics were given.Results. Using bioinformatic search algorithms in the genome of antibiotic-resistant strains, functionally active CRISPR/Cas systems with the presence of one or two CRISPR cassettes and belonging to Type I Subtype IE were identified. Groups of resistant strains with identical spacer composition of CRISPR cassettes have been identified. A phylogenetic analysis was carried out confirming their common origin. By analyzing the spacer sequences of CRISPR cassettes, the spectrum of diversity of phages of bacteria of the genus Klebsiella, Salmonella, belonging to the same family Enterobacteriaceae, was determined. Thus, information was obtained about the bacteriophages that are targeted by the action of CRISPR systems of Klebsiella pneumoniae strains that have antibiotic resistance.Conclusions. Analysis of the functional and structural features of the CRISPR/Cas systems of antibiotic resistant Klebsiella pneumoniae strains made it possible to obtain information about their evolutionary history and about the bacteriophages against which their action is directed, that is, about their phage resistance. The approach used in this study may further serve as the basis for the creation of personalized phage therapy

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Epidemiological Analysis of Antimicrobial Resistance in Staphylococcus epidermidis in Scotland, 2014–2018

Cited by 3 publications

References 20 publications

Analysis of distribution and antibiotic resistance of Gram-positive bacteria isolated from a tertiary-care hospital in southern China: an 8-year retrospective study

Analysis of distribution and antibiotic resistance of Gram-positive bacteria isolated from a tertiary-care hospital in southern China: an 8-year retrospective study

Antibiotic therapy and awareness of antibiotic resistance problem in medical practice

Identification and analysis of CRISPR/Cas systems structures in the genomes of antibiotic-resistant strains of <i>Klebsiella pneumoniae</i>

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