Epidemiologic trends in lung cancer over two decades in Northern Greece: an analysis of bronchoscopic data

Abstract

Background and Aim. The relative frequency of histological subtypes of lung cancer in Europe has changed dramatically during the 20th century. The aim of this study was to explore the changing epidemiology of lung cancer in Northern Greece over the last two decades. Methods. From the extensive database of the Bronchoscopy Unit of the G. Papanicolaou General Hospital, Thessaloniki, Greece, we identified all patients with a histologic and/or cytologic report positive for lung cancer over two consecutive decades. Results. Between 1/1/1986 and 31/12/2005 we identified 9981 patients with specimens positive for lung cancer. A significant increase in mean patient age was observed during the second decade (64.8±9.4 vs. 62.1±8.9, p=0.001). Men developed lung cancer ten times more often than women. The predominant histological type was squamous cell cancer in males (4203 cases, 45.7%) and adenocarcinoma (418 cases, 52.6%) in females. The number of lung cancer cases was significantly higher during the second decade compared to the first decade (5766 cases [57.8%] vs. 4215 cases [42.2%], respectively, p<0.001). There was a significant decrease in the percentage of squamous cell carcinoma in males in the second decade (2317 cases [44.1%] vs. 1886 cases [48.0%], p<0.001), and an increase in adenocarcinoma (1021 cases [19.4%] vs. 609 [11.6%], p<0.001). In females, the relative incidence of adenocarcinoma was decreased and that of squamous cell carcinoma was increased, but not significantly. There was no obvious change in the incidence of small cell lung cancer. Neoplastic lesions were most often located in the upper lobes. Conclusion. The number of lung cancer cases has increased in the last decade. Squamous lung cancer appears to be decreasing in men and increasing in women. Adenocarcinoma appears to be increasing in men and decreasing in women. There appears to be no change in small cell lung cancer. During the second decade there has been a significant decrease in the male: female ratio.

Epidemiology of lung cancer in Northern Greece: An 18- year hospital-based cohort study focused on the differences between smokers and non-smokers

“…Squamous cell carcinoma, rather than adenocarcinoma, has been traditionally thought to be related to smoking. Similar results have been reported in an earlier analysis of data beginning almost four decades ago from the same Hospital, focusing in two-decade differences in another target population (the region of Thrace included) 18 . In contrast, in other populations, adenocarcinoma has been found to be the most common type 19,20 .…”

Thyroid Gland as a Target of Secondary Malignancies - an Autopsy Study and Review Data

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Distinctive Patterns of Initially Presenting Metastases and Clinical Outcomes According to the Histological Subtypes in Stage IV Non-Small Cell Lung Cancer

“…The results of a more frequent distribution of advanced age (≥65 years) and male sex in SQ were concordant with those of previous publications. 4 , 5 , 20 Metastatic distributions were absolutely distinguishing, with higher metastatic scores being found in Adenoca. The metastatic sites were also significantly and differently distributed to the whole body, with tropism for lung, bone, and brain in Adenoca.…”