Epidemiologic surveillance of multidrug-resistant bacteria in a teaching hospital: A 3-year experience

Zarpellon, Mirian Nicéa; Viana, Giselle Fukita; Mitsugui, Cecília Saori; Costa, Bruno Buranello; Tamura, Nathalie Kira; Aoki, Elisabeth Eyko; Helbel, César; Nishiyama, Sheila Alexandra Belini; Saalfeld, Silvia Maria dos Santos; Tognim, Maria Cristina Bronharo

doi:10.1016/j.ajic.2017.10.012

Cited by 9 publications

(12 citation statements)

References 24 publications

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“…Zarpellon et al established a Surveillance Program in a teaching hospital during the period from 2012 to 2014 in Southern Brazil (Maringa, PR) (10). The most common isolates from inpatients were almost the same as our study, with E. coli corresponding to 21%, S. aureus 14%, and CoNS 13%, with only one difference-the percentages of CoNS, that represented 22% of inpatient isolates in our study.…”

Section: Discussionsupporting

confidence: 67%

“…Also, we verified K. pneumoniae resistance to gentamicin, to which KPC-producing K. pneumoniae may occasionally be susceptible to, allowing for monotherapy using this drug (32). We observed a resistance rate of 62.1%, higher than rates reported by Sader et al (10). Our results show higher than the calculated average (28.9%) resistance.…”

Section: The Eskape Group-klebsiella Pneumoniaesupporting

confidence: 76%

“…resistance to meropenem to determine the current situation in terms of CRAB. We found a high resistance rate of 81.4%, expressively higher than 8% reported by Sader et al (13), 25% reported by De Carvalho and Gontijo Filho (16), 56.4% reported by Marra et al (12) and comparable to 77.6% reported recently by Zarpellon et al (10). Therefore, we notice a historical pattern of progressive growth in resistance rates that accompanies the timeline of the detection of genetic determinants of resistance.…”

Section: The Eskape Group-acinetobacter Baumanniisupporting

confidence: 70%

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The Experience of Implementing a National Antimicrobial Resistance Surveillance System in Brazil

Pillonetto

Jordão

Andraus

et al. 2021

Front. Public Health

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Antimicrobial resistance (AMR) is a major public health threat of global proportions, which has the potential to lead to approximately ten million deaths per year by 2050. Pressured by this wicked problem, in 2014, the World Health Organization launched a call for member states to share AMR data through the implementation of the Global Antimicrobial Resistance Surveillance System (GLASS), to appropriately scale and monitor the general situation world-widely. In 2017, Brazil joined GLASS and, in 2018, started its own national antimicrobial surveillance program (BR-GLASS) to understand the impact of resistance in the country. We compiled data obtained from the complete routine of three hospitals' microbiology labs during the year of 2018. This pilot data sums up to 200,874 antimicrobial susceptibility test results from 11,347 isolates. It represents 119 different microorganisms recovered from 44 distinct types of clinical samples. Specimens came from patients originating from 301 Brazilian cities, with 4,950 of these isolates from presumed Healthcare-Associated Infections (HAIs) and the other 6,397 community-acquired cases. The female population offered 58% of the collected samples, while the other 42% were of male origin. The urinary tract was the most common topography (6,372/11,347 isolates), followed by blood samples (2,072/11,347). Gram-negative predominated the bacterial isolates: Escherichia coli was the most prevalent in general, representing 4,030 isolates (89.0% of these from the urinary tract). Coagulase-negative Staphylococci were the most prevalent bacteria in blood samples. Besides these two species, the ESKAPE group have consolidated their prevalence. Regarding drug susceptibility results, 141,648 (70.5%) were susceptible, 9,950 (4.9%) intermediate, and 49,276 (24.5%) resistant. Acinetobacter baumannii was the most worrisome microorganism, with 65.3% of the overall antimicrobial susceptibility tests showing resistance, followed by ESBL-producing Klebsiella pneumoniae, with a global resistance rate of 59%. Although this is a pilot project (still limited to one state), this database shows the importance of a nation-wide surveillance program,[153mm][-12mm] Q14 especially considering it already had patients coming from 301 distinct counties and 18 different states. The BR-GLASS Program is an ongoing project that intends to encompass at least 95 hospitals distributed in all five geographical regions in Brazil within the next 5 years.

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Section: Discussionsupporting

confidence: 67%

Section: The Eskape Group-klebsiella Pneumoniaesupporting

confidence: 76%

Section: The Eskape Group-acinetobacter Baumanniisupporting

confidence: 70%

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The Experience of Implementing a National Antimicrobial Resistance Surveillance System in Brazil

Pillonetto

Jordão

Andraus

et al. 2021

Front. Public Health

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“…As shown by Figure 3 , resistance patterns differ at the three hospitals, despite all being tertiary-level and located in the same city. Surveillance systems are essential for providing the information needed to develop local therapy guidelines and antibiotic control policies ( 29 – 31 ). Moreover, adequate surveillance would enable individual health care centers to take action against various risk factors and weaknesses to reduce the spread of MDR bacteria and prevent outbreaks ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial resistance profiles of microorganisms isolated from hospitalized patients in Dominican Republic

Luna¹,

Sánchez

Peguero

et al. 2020

Revista Panamericana De Salud Pública

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Objective. To define the antimicrobial resistance profiles of the microorganisms most commonly isolated from hospitalized adult patients in Dominican Republic (DR). Methods. A retrospective, cross-sectional study of phenotypic antimicrobial susceptibility patterns was conducted using data from 3 802 clinical microbiology reports specifying positive bacterial cultures in samples collected from patients admitted to the clinical, surgery, and intensive care units (ICU) at three tertiary-level care hospitals in the city of Santiago de los Caballeros from 1 January 2016 – 31 December 2017. Descriptive statistics and chi-square test (P ≤ 0.05) were used to analyze the qualitative variables. Results. At the three hospitals, there were 932, 1 090, and 1 780 microbiology reports analyzed. Of the total, 1274 were from the ICU, 1 042 from the surgery unit, and 1 486 from the clinical unit. Methicillin resistance was found in 57.3% of the Staphylococcus aureus isolates and 75.3% of the coagulase-negative staphylococci. Third-generation cephalosporin resistance was detected in 54.4% of isolates identified as members of the Enterobacteriaceae family, 67.3% of the Acinetobacter spp., and 91.7% of the Pseudomonas, while carbapenem resistance was shown by 8.0%, 23.8%, and 51.0% of these, respectively. Most of the resistant Acinetobacter spp. isolates were found in just one hospital and the prevalence of Enterobacteriaceae resistant to carbapenems was highest in the ICU. Conclusion. Antimicrobial resistance levels are high among hospitalized patients in Dominican Republic and may cause enhanced risk factors that impact clinical outcomes. Urgent measures are needed to address antimicrobial resistance in DR.

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“…Maringá" (ZARPELLON et al, 2017 Santos (2007), que esta é uma das espécies de maior importância no quadro das infecções hospitalares e comunitárias. (CLSI, 2017).…”

Section: Materials E Métodos Os Dadosunclassified

AVALIAÇÃO DA TENDÊNCIA TEMPORAL DA RESISTÊNCIA BACTERIANA EM ISOLADOS DE Staphylococcus SPP.

Gardelli¹,

Mazucheli²,

Tognim³

et al. 2018

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Epidemiologic surveillance of multidrug-resistant bacteria in a teaching hospital: A 3-year experience

Cited by 9 publications

References 24 publications

The Experience of Implementing a National Antimicrobial Resistance Surveillance System in Brazil

The Experience of Implementing a National Antimicrobial Resistance Surveillance System in Brazil

Antimicrobial resistance profiles of microorganisms isolated from hospitalized patients in Dominican Republic

AVALIAÇÃO DA TENDÊNCIA TEMPORAL DA RESISTÊNCIA BACTERIANA EM ISOLADOS DE Staphylococcus SPP.

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