Epidemiologic Study of Kawasaki Disease in Korea, 1997-1999: Comparison with Previous Studies During 1991-1996

Park, Yong Won; Park, In Sook; Kim, Chang Hwi; Suk, Jae; Lee, Sang Bum; Kim, Chul Ho; Yun, Yong Soo; Lee, Heung Jae; Lee, Sung Kyu; Tockgo, Young Chang

doi:10.3346/jkms.2002.17.4.453

Cited by 33 publications

(37 citation statements)

References 6 publications

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“…Similar seasonal summer clustering also has been reported for Japan, Korea, and Beijing, 3,6,16 although in the United States, KD has been reported to occur slightly more frequently in the winter. 9 One cause of this seasonal clustering may be a seasonal viral or bacterial infection, although this would require additional studies.…”

Section: Discussionmentioning

confidence: 51%

Epidemiologic Features of Kawasaki Disease in Taiwan, 1996–2002

Chang

et al. 2004

Pediatrics

104

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ABSTRACT. Objective. Kawasaki disease (KD) is the most common acquired heart disease in children worldwide. The incidence of KD varies among different countries, with Asian countries supposedly having higher incidences than Western countries. However, the incidence of KD in Taiwan has not been well investigated.Methods. Since the implementation of Taiwan's National Health Insurance (NHI) in 1995, NHI has covered health care for >96% its population. Using the NHI database from 1996 to 2002, we investigated epidemiologic features of KD (International Classification of Diseases, Ninth Revision, code 446.1), the rate of coronary artery aneurysm formation (International Classification of Diseases, Ninth Revision, code 414.11), and the change in incidence during the recent 7 years. We also compared the annual incidences in Taiwan with those reported by other countries.Results. During the 7-year study period, KD occurred most frequently in the summer and least frequently in winter. It is interesting that the highest peak occurred in the summer of 1998 at the same time that Taiwan's enterovirus 71 epidemic was occurring. Ninety-one percent of KD cases occurred in children who were <5 years old, and the male-to-female ratio was 1.70:1. Recurrence of KD was found in 1.3% (94 of 7305) of these children, and coronary artery aneurysm was found in 7.3% (536 of 7305). The annual incidence per 100 000 children was 146 in children <1 year old, 98 in 1-year-old children, 51 in 2-year-old children, 28 in 3-year-old children, 19 in 4-year-old children, and 5.3 in 5-to 9-year-old children; the incidence of KD decreased with increased age. The overall incidence was 66 cases per 100 000 children <5 years old from 1996 to 2002 with the annual incidence not differing significantly during the 7-year study period.Conclusions. KD in Taiwan occurs more frequently in boys and in the summer months. During the 7-year study period, the annual KD incidence in Taiwan of 66/100000 in children <5 years old was the second highest in the world after Japan. Kawasaki,1 it is now the most common cause of acquired heart disease in children in the developed world. Although usually self-limiting, KD is associated with a range of complications, the most important being the development of life-threatening coronary artery abnormalities.Reported incidences of KD in different countries vary widely. For example, Japan has the highest annual incidence in the world. It reported 100 to 110 KD cases per 100 000 children Ͻ5 years old between 1995 and 1998 but with ϳ200 cases per 100 000 in times of epidemic. [2][3][4][5] Beijing reported annual citywide incidence of 18.2 to 30.6 per 100 000 from 1995 to 1999, 6 and Hong Kong reported an annual incidence of 25.4 per 100 000 from 1989 to 1994 and 32 from 1994 to 2000. 7,8 Among the annual incidences reported for Western countries, the United States reported 17.6 and 17.1 cases per 100 000 children Ͻ5 years old in 1997 and 2000, respectively, 9 and from 1996 to 1999, the United Kingdom reported 5.5 per 100 000 childre...

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Section: Discussionmentioning

confidence: 51%

Epidemiologic Features of Kawasaki Disease in Taiwan, 1996–2002

Chang

et al. 2004

Pediatrics

104

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“…17 The epidemiologic characteristics of KS patients reported to the KS surveillance system were similar to those reported in many other studies. 8,9,11,18 Although the number of reported KS cases did not substantially increase during the 10-year surveillance period, the proportion of KS patients with CAA showed an increasing trend, particularly after 1999. As shown in Figure 4, the increase was clearly the result of an increase in the proportion of patients with coronary artery dilatations, and not coronary artery aneurysms.…”

Section: Discussionmentioning

confidence: 89%

“…This proportion was similar to that reported for children in Japan (Ն20.1%), Korea (21.0%), and Beijing (21.5%) and Shaanxi Province (19.0%), China. 8,9,18,20 A number of other noncoronary artery complications were reported among the KS patients. Noncoronary cardiac complications included pericarditis, valvular regurgitation and congestive heart failure.…”

Section: Discussionmentioning

confidence: 95%

Kawasaki Syndrome and Risk Factors for Coronary Artery Abnormalities

Belay

Maddox

Holman

et al. 2006

The Pediatric Infectious Disease Journal

123

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“…There was a striking inverse correlation between the incidence of KD [8,10,[25][26][27][28][29][30][31] and the frequency of the CCR5-D32 allele [5,[32][33][34][35][36][37] in different geographic regions (figure 1). Thus, countries with the lowest incidences of KD had the highest frequencies of the CCR5-D32 allele.…”

Section: Resultsmentioning

confidence: 99%

Genetic Variations in the Receptor‐Ligand PairCCR5andCCL3L1Are Important Determinants of Susceptibility to Kawasaki Disease

et al. 2005

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Kawasaki disease (KD) is an enigmatic, self-limited vasculitis of childhood that is complicated by development of coronary-artery aneurysms. The high incidence of KD in Asian versus European populations prompted a search for genetic polymorphisms that are differentially distributed among these populations and that influence KD susceptibility. Here, we demonstrate a striking, inverse relationship between the worldwide distribution of CCR5- Delta 32 allele and the incidence of KD. In 164 KD patient-parent trios, 4 CCR5 haplotypes including the CCR5- Delta 32 allele were differentially transmitted from heterozygous parents to affected children. However, the magnitude of the reduced risk of KD associated with the CCR5- Delta 32 allele and certain CCR5 haplotypes was significantly greater in individuals who also possessed a high copy number of the gene encoding CCL3L1, the most potent CCR5 ligand. These findings, derived from the largest genetic study of any systemic vasculitis, suggest a central role of CCR5-CCL3L1 gene-gene interactions in KD susceptibility and the importance of gene modifiers in infectious diseases.

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Epidemiologic Study of Kawasaki Disease in Korea, 1997-1999: Comparison with Previous Studies During 1991-1996

Cited by 33 publications

References 6 publications

Epidemiologic Features of Kawasaki Disease in Taiwan, 1996–2002

Epidemiologic Features of Kawasaki Disease in Taiwan, 1996–2002

Kawasaki Syndrome and Risk Factors for Coronary Artery Abnormalities

Genetic Variations in the Receptor‐Ligand PairCCR5andCCL3L1Are Important Determinants of Susceptibility to Kawasaki Disease

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