Epidemiologic study of insecticide exposures, obesity, and risk of bladder cancer in household dogs

Glickman, Lawrence T.; Schofer, Frances S.; McKee, Linda J.; Reif, John S.; Goldschmidt, Michael H.

doi:10.1080/15287398909531360

Cited by 127 publications

(104 citation statements)

References 6 publications

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“…6 Bladder cancer risk was not related to sidestream cigarette smoke and household chemical exposure. There was, however, a significant, dose-related association between topical application of flea and tick dip and TCC.…”

Section: Insecticides Obesity and Sexmentioning

confidence: 99%

“…In addition, risk of TCC was higher in dogs living near marshland sprayed with insecticide(s). 6 The authors speculated that the ''inert'' ingredients, accounting for Ͼ95% of the total product, were the probable carcinogens in these products.…”

Section: Insecticides Obesity and Sexmentioning

confidence: 99%

“…Risk factors that have been identified include exposure to topical insecticides for flea and tick control, exposure to marshes that have been sprayed for mosquito control, obe-sity, possibly cyclophosphamide a administration, female sex, and specific breeds (eg, Scottish Terrier). 4,[6][7][8] In addition to these risk factors, a 1981 study showed a significant positive correlation between the proportional morbidity ratios for canine bladder cancer and the overall level of industrial activity in the host county of the veterinary hospital. 9 Bladder cancer mortality in Caucasian men and women in the same counties showed a similar correlation with industrial activity, 9 thus suggesting a role for environmental pollution.…”

Section: Etiology and Risk Factorsmentioning

confidence: 99%

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Canine Transitional Cell Carcinoma

Mutsaers

Widmer

Knapp

2003

Veterinary Internal Medicne

189

217

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Transitional cell carcinoma (TCC) of the urinary bladder, the most common malignancy of the urinary tract in dogs, is challenging to both diagnose and treat effectively. The prevalence of this disease may be increasing. The etiology of canine TCC is likely multifactorial. Epidemiological studies of TCC in the dog have revealed a number of risk factors, including breed and female gender, as well as environmental factors, such as insecticide exposure. This tumor is difficult to remove surgically and responds poorly to chemotherapy. The efficacy of radiotherapy and other treatment modalities needs further investigation. Cyclooxygenaseinhibiting drugs have some activity against TCC, and studies to further define these effects are ongoing. Use of the tumor/node/ metastasis (TNM) classification scheme for bladder cancer has allowed for the identification of prognostic factors. Urinary tract obstruction and metastatic disease remain challenges to treat. Work with canine TCC has demonstrated how closely this disease resembles human invasive urinary bladder cancer. Therefore, future research has the potential to benefit both dogs and humans with TCC.Key words: Animal models; Bladder cancer; Chemotherapy; Cyclooxygenase; Piroxicam; Risk factors.U rinary bladder cancer in dogs is a challenging disease to diagnose, stage, and treat. Fortunately, urinary bladder cancer is uncommon in the dog, comprising Ͻ2% of all reported canine malignancies. 1 Transitional cell carcinoma (TCC) is the most common neoplasm affecting the urinary bladder of dogs. In this article, we review current knowledge of canine TCC with regard to frequency, etiology, histopathological characteristics, cellular and molecular features, response to therapy, and prognostic factors. We also discuss why canine TCC is a good model of human invasive bladder cancer. FrequencyAlthough the true prevalence of canine TCC is not known, it is the most common form of urinary tract cancer in the dog and comprises 1.5-2% of all canine cancers. 2,3 The hospital prevalence, or proportionate morbidity, of bladder cancer at university-based veterinary hospitals appears to be increasing. 4 A search of the Veterinary Medical Data Base (VMDB) 5 from 1975 to 1995 showed a continuous increase in the prevalence of bladder cancer, with prevalence defined as the number of dogs with bladder cancer divided by the total number of individual dogs seen for any reason at the same participating university veterinary hospitals. 4 Etiology and Risk FactorsThe etiology of canine TCC is most likely multifactorial. Risk factors that have been identified include exposure to topical insecticides for flea and tick control, exposure to marshes that have been sprayed for mosquito control, obe- University, West Lafayette, IN. Reprint requests: Deborah W. Knapp, DVM, MS, DACVIM, Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN 47907-1248; e-mail: knappdw@purdue.edu. Submitted December 28, 2001; Revised April 23, 2002; Accepted June 17, 2002. Copyright ᭧ 2003 sity, ...

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Section: Insecticides Obesity and Sexmentioning

confidence: 99%

Section: Insecticides Obesity and Sexmentioning

confidence: 99%

Section: Etiology and Risk Factorsmentioning

confidence: 99%

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Canine Transitional Cell Carcinoma

Mutsaers

Widmer

Knapp

2003

Veterinary Internal Medicne

189

217

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“…A marginal excess risk of lung cancer was observed in dogs aged 10 years or less and exposed to household tobacco smoke in one study (Reif et al, 1992). Risk of bladder cancer in dogs was not related to exposure to household cigarette smoke in another study (Glickman et al, 1989).…”

Section: Observational Studies Of Companion Animalsmentioning

confidence: 99%

Secondhand Tobacco Smoke

2011

Encyclopedia of Cancer

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“…For example, obesity was identified as a risk factor in association with pesticides for the development of transitional cell carcinomas in Scottish Terrier dogs. 29 Thus, maintaining ideal body weight may also reduce the risk for the development of a variety of tumors and reduce the incidence of pancreatitis, diabetes mellitus, and bone and joint diseases. Recently, studies of lifelong diet restriction in Labrador Retrievers indicated a 1.8-year longer survival in the leaner dogs.…”

Section: Dietary Compounds and Cancer Chemopreventionmentioning

confidence: 99%

Review Paper: Cancer Chemopreventive Compounds and Canine Cancer

2009

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Abstract. Canine cancer has become more prevalent in recent years because of increased life expectancy and greater attention to the health of pets. The range of cancers seen in dogs is as diverse as that in human patients, and despite more intensive therapeutic interventions, fatality rates remain unacceptably high in both species. Chemoprevention is therefore an important means of confronting this disease. Because domestic pets share our environment, greater cross-application and study of the protumorigenic and antitumorigenic factors in our shared environment will benefit all species, leading to the development of new families of less toxic antitumorigenic compounds based on novel and established molecular targets. Currently, the most interesting cancer preventive agents are nonsteroidal antiinflammatory drugs, peroxisome proliferator-activated receptor-c ligands, and dietary compounds. This article provides an overview of what is known about how these agents affect molecular signaling in neoplastic disease, with reference to reported application and/or study in dogs where available.

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Epidemiologic study of insecticide exposures, obesity, and risk of bladder cancer in household dogs

Cited by 127 publications

References 6 publications

Canine Transitional Cell Carcinoma

Canine Transitional Cell Carcinoma

Secondhand Tobacco Smoke

Review Paper: Cancer Chemopreventive Compounds and Canine Cancer

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