Epidemiologic Study of 20 Cases of Pemphigus at Hospital Clínico Universitario Virgen de la Victoria de Málaga, Spain

Alcaide-Martín, A.J.; Gallardo-Pérez, M.A.; Castillo-Muñoz, R.; Fernández, M.V. Mendiola; Herrera‐Ceballos, Enrique

doi:10.1016/s1578-2190(10)70837-4

Cited by 14 publications

(24 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies registered the highest frequency in females [21,39-46], while a few studies have reported males’ dominance [41,47]. In general, estrogen (exogenous and endogenous) has been accused for the females’ predominance in autoimmune diseases [48].…”

Section: Discussionmentioning

confidence: 99%

Clinical and histological characterization of oral pemphigus lesions in patients with skin diseases: a cross sectional study from Sudan

et al. 2013

View full text Add to dashboard Cite

BackgroundPemphigus is a rare group of life-threatening mucocutaneous autoimmune blistering diseases. Frequently, oral lesions precede the cutaneous ones. This study aimed to describe clinical and histological features of oral pemphigus lesions in patients with skin disease has been canceled aged 18 years and above, attending outpatient’s facility of Khartoum Teaching Hospital - Dermatology Clinic, Sudan. In addition, the study aimed to assess the diagnostic significance of routine histolopathology along with immunohistochemical (IHC) examination of formalin-fixed, paraffin-embedded biopsy specimens in patients with oral pemphigus.MethodsA cross-sectional hospital-based study was conducted from October 2008 to January 2009. A total of 588 patients with confirmed skin has been canceled disease diagnosis completed an oral examination and a personal interview. Clinical evaluations supported with histopathology were the methods of diagnosis. IHC was used to confirm the diagnosis. Location, size, and pain of oral lesions were used to measure the oral disease activity.ResultsTwenty-one patients were diagnosed with pemphigus vulgaris (PV), 19 of them (mean age: 43.0; range: 20–72 yrs) presented with oral manifestations. Pemphigus foliaceus was diagnosed in one patient. In PV, female: male ratio was 1.1:1.0. Buccal mucosa was the most commonly affected site. Exclusive oral lesions were detected in 14.2% (3/21). In patients who experienced both skin and oral lesion during their life time, 50.0% (9/18) had oral mucosa as the initial site of involvement, 33.3% (6/18) had skin as the primary site, and simultaneous involvement of both skin and oral mucosa was reported by 5.5% (1/18). Two patients did not provide information regarding the initial site of involvement. Oral lesion activity score was higher in those who reported to live outside Khartoum state, were outdoor workers, had lower education and belonged to Central and Western tribes compared with their counterparts. Histologically, all tissues except one had suprabasal cleft and acantholytic cells. IHC revealed IgG and C3 intercellularly in the epithelium.ConclusionsPV was the predominating subtype of pemphigus in this study. The majority of patients with PV presented with oral lesions. Clinical and histological pictures of oral PV are in good agreement with the literature. IHC confirmed all diagnoses of PV.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical and histological characterization of oral pemphigus lesions in patients with skin diseases: a cross sectional study from Sudan

et al. 2013

View full text Add to dashboard Cite

show abstract

“…It describes a group of disorders that have varied presentation involving skin and mucous membranes; PV produces blisters in skin and mucous membranes, while pemphigus foliaceus involves skin only, paraneoplastic pemphigus produces blisters in patients with underlying malignancy and endemic pemphigus is seen in Brazilian population 4. PV is an autoimmune, blistering, inflammatory disease of epidermal layer of the skin.…”

Section: Discussionmentioning

confidence: 99%

“…Patients usually seek medical attention because of dysphagia or odynophagia caused by oral mucosal lesions or because of blisters in the skin, as noted in our patient. More than 90% patients present at 40 years of age but it has been reported between 15 and 87 years of age 4. Oral steroids till the lesions heal are sufficient in 40% cases, while in the remaining 60% cases other immunosuppressants are required 4.…”

Section: Discussionmentioning

confidence: 99%

“…More than 90% patients present at 40 years of age but it has been reported between 15 and 87 years of age 4. Oral steroids till the lesions heal are sufficient in 40% cases, while in the remaining 60% cases other immunosuppressants are required 4. The treatment outcomes are measured by PV disease area index as well as pemphigus severity score 13.…”

Section: Discussionmentioning

confidence: 99%

“…The disease requires long-term treatment with a mean of 6 months, up to 36 months 4. The patient is considered to be in remission off therapy, in the absence of new lesions or established lesions for at least 2 months without treatment and remission on therapy, in absence of lesions with minimal therapy; which is defined as requirement of 10 mg/day of prednisolone or 50% of the dose of immunosuppressants as required in therapy failure 13.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Pemphigus vulgaris in a pregnant woman and her neonate

Ibrahim

Yashodhara²,

Umakanth³

et al. 2012

Case Reports

View full text Add to dashboard Cite

A clinical and demographic analysis of oral pemphigus vulgaris: A retrospective cross‐sectional study from 2001 to 2021

Alshami

Aswad

Abdullah

2022

Health Science Reports

View full text Add to dashboard Cite

Background and Aims: Pemphigus vulgaris is an autoimmune vesiculobullous mucocutaneous disorder with life-threatening consequences. Early detection and adequate care are crucial for a good prognosis. This study aimed to determine the demographic data, clinical features, and the prognosis of patients with oral pemphigus vulgaris.Materials and Methods: From 2001 to 2021, all diagnosed oral pemphigus vulgaris cases were extracted. Each patient's demographic and clinical data were gathered.Patients were called via phone to assess the prognosis, treatment type, and specialty of the physician who provided the diagnosis and therapy.Results: The majority of the patients had only oral lesions with higher prevalence in female who also expressed severe pain than male. Only 14 of 29 patients responded phone calls. Except for one, all patients were in active disease. More than half of those respondents said pemphigus negatively affects social behavior and food intake. Correct diagnosis and treatment were decided by dermatology, oral medicine, and maxillofacial surgery specialists. Conclusion:Oral pemphigus vulgaris was prevalent in females. Severe pain was common in females and older people. Even with effective therapy, the prognosis was poor. Medical and dental professionals had little knowledge of pemphigus vulgaris.Patients frequently report poor quality of life.

show abstract

Epidemiologic Study of 20 Cases of Pemphigus at Hospital Clínico Universitario Virgen de la Victoria de Málaga, Spain

Cited by 14 publications

References 23 publications

Clinical and histological characterization of oral pemphigus lesions in patients with skin diseases: a cross sectional study from Sudan

Clinical and histological characterization of oral pemphigus lesions in patients with skin diseases: a cross sectional study from Sudan

Pemphigus vulgaris in a pregnant woman and her neonate

A clinical and demographic analysis of oral pemphigus vulgaris: A retrospective cross‐sectional study from 2001 to 2021

Contact Info

Product

Resources

About