Epidemiologic Study and Genotyping in Renal Transplant Recipients BK Virus

Cobos, Marisa; Aquilia, Liliana; Gomez, Tatiana Socarras; Flores, Daniela; Raimondi, J. Clemente

doi:10.1097/01.tp.0000543606.23782.7b

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found that BKV subtype I is the most prevalent subtype among KTx recipients in the United States, followed by BKV subtype IV. These findings are consistent with other countries from different continents . While the data on trend of BK subtypes among other countries were limited, we found a significant positive correlation between year of study and the prevalence of BKV subtype I in the United States, suggesting potential increasing prevalence of BKV subtype I overtime.…”

Section: Discussionsupporting

confidence: 91%

“…After exclusion of 231 articles based on title and abstract for clearly not fulfilling inclusion criteria due to type of article, study design, population or outcome of interest, and 47 articles excluded due to being duplicates, 71 articles were left for full‐length review. Subsequently, 63 articles were additionally excluded (25 articles did not report the outcome of interest; 17 were not observational studies; and 21 articles were excluded because they were from countries outside the United States and/or consisted of a pediatric population). Thus, eight observational studies with a total of 193 samples (urine, blood, and kidney tissues) from 188 BKV‐infected KTX adult recipients in the United States were enrolled.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

BK polyomavirus genotypes in renal transplant recipients in the United States: A meta‐analysis

Khoury

Aeddula

Boonpheng

et al. 2019

J Evidence Based Medicine

View full text Add to dashboard Cite

Background In the United States, increasing ethnic diversity has been apparent. However, the epidemiology and trends of BKV genotypes remain unclear. This meta‐analysis was conducted with the aim to assess the prevalence of BKV genotypes among kidney transplant (KTx) recipients in the United States. Methods A comprehensive literature review was conducted through October 2018 utilizing MEDLINE, Embase, and Cochrane Database to identify studies that reported the prevalence of BKV subtypes and/or subgroups in KTx recipients in the United States. Pooled prevalence rates were combined using random effects, generic inverse variance method. The protocol for this study is registered with PROSPERO (no. CRD42019134582). Results A total of eight observational studies with a total of 193 samples (urine, blood, and kidney tissues) from 188 BKV‐infected KTX recipients were enrolled. Overall, the pooled estimated prevalence rates of BKV subtypes were 72.2% (95% confidence of interval [CI]: 62.7‐80.0%) for subtype I, 6.8% (95% CI: 2.5‐16.9%) for subtype II, 8.3% (95% CI: 4.4‐15.1%) for subtype III, and 16.1% (95% CI: 10.4‐24.2%) for subtype IV, respectively. While metaregression analysis demonstrated a significant positive correlation between year of study and the prevalence of BKV subtype I (slopes = +0.1023, P = .01), there were no significant correlations between year of study and percentages of BKV subtype II‐IV (P > .05). Among KTx recipients with BKV subtype I, the pooled estimated percentages of BKV subgroups were 22.4% (95% CI: 13.7‐34.5%) for subgroup Ia, 30.6% (95% CI: 17.7‐47.5%) for subgroup Ib1, 47.7% (95% CI: 35.8‐59.9%) for subgroup Ib2, and 4.1% (95% CI:1.2‐13.3%) for subgroup Ic, respectively. Conclusion BKV subtype I is the most prevalent subtype among KTx recipients in the United States and its prevalence seems to increasing overtime. Subgroup Ib2 is the most common subgroup among BKV subtype I.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%