Epidemiologic picture of Kawasaki disease in Korea, 2000–2002

Park, Yong Won; Han, Jieun; Park, In Sook; Kim, Chang Hwi; Yun, Yong Soo; Ho, Sung; Sook, Jae; Lee, Sang Bum; Kim, Chul Ho; Lee, Heung Jae; Tockgo, Young Chang

doi:10.1111/j.1442-200x.2005.02079.x

Cited by 41 publications

(45 citation statements)

References 14 publications

(38 reference statements)

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“…Moreover, KD is overrepresented in Asian children (1,9-13). The annual incidence of KD in Taiwan is estimated to be 66/100,000 children, the third highest in the world after Japan and Korea (3,14).…”

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confidence: 99%

HLA–E gene polymorphism associated with susceptibility to kawasaki disease and formation of coronary artery aneurysms

Lin¹,

Wan²,

Wu³

et al. 2009

Arthritis & Rheumatism

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Objective. Kawasaki disease (KD) is a pediatric systemic vasculitis of unknown cause for which a genetic influence is supposed. The purpose of this study was to identify possible genetic variants in the major histocompatibility complex (MHC) region that are associated with KD and the development of coronary artery aneurysms (CAAs) in a Taiwanese population.Methods. The 168 genetic variants covering the MHC locus were analyzed in an association study of a Taiwanese cohort of 93 KD patients and 680 unrelated healthy children matched for sex and age with the study patients.Results. Eleven single-nucleotide polymorphisms (SNPs) were associated with the occurrence of KD. The SNP located at the 3 -untranslated region of HLA-E (rs2844724) was highly associated (P < 1 ؋ 10 ؊7 ). In addition, the frequency of the C allele was higher in KD patients without CAAs than in controls (P < 0.001) due to a significantly increased frequency of the CC and CT genotypes. Plasma levels of soluble HLA-E were significantly higher in KD patients than in controls regardless of the presence of CAAs. Furthermore, there was a trend toward higher plasma levels of soluble HLA-E in KD patients with the CT and TT genotypes of the HLA-E gene polymorphism.Conclusion. Our results suggest that the HLA-E gene polymorphism may play a role in the pathogenesis of KD.

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confidence: 99%

HLA–E gene polymorphism associated with susceptibility to kawasaki disease and formation of coronary artery aneurysms

Lin¹,

Wan²,

Wu³

et al. 2009

Arthritis & Rheumatism

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“…First, as mentioned earlier, KD is over-represented among Asian and Asian-American populations. [6][7][8][9][10][11]18 The fact that Japanese ancestries in Hawaii have higher incidence of KD than other ethnic groups and the same level of incidence as Japanese living in Japan confirms the ethnic genetic difference in susceptibility to KD. Second, KD shows familial aggregation.…”

Section: Epidemiological Findings Indicating Genetic Predisposition Fmentioning

confidence: 87%

Susceptibility genes for Kawasaki disease: toward implementation of personalized medicine

Hata

Onouchi

2009

J Hum Genet

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Kawasaki disease (KD) is an acute systemic vasculitis syndrome, which primarily affects in children under the age of 5 years. In 20-25% of cases, if untreated, coronary artery lesions develop, making KD the leading cause of acquired heart disease in children in both Japan and the United States. Since 1970, 19 nationwide surveys of KD in Japan have been conducted every 2 years and the data are stored in a database. Even though the etiology of KD remains unknown, despite enthusiastic research spanning more than 40 years, we have learnt a great deal about KD from this enormous database. These 19 epidemiologic studies indicate a strong genetic influence on the disease susceptibility, prompting us and other researchers to identify the responsible genes for KD by applying either the candidate gene approach or the genome-wide approach. We have employed a genome-wide linkage study using affected sibling pair data of KD in Japan and have identified several susceptibility loci. Further analysis focusing on a region of chromosome 19, where one of the linked loci was detected, identified a predisposing gene, which codes inositol 1,4,5-trisphosphate 3-kinase C (ITPKC). In this review, we summarize the cumulative knowledge regarding KD, and then outline our hypothesis of the role ITPKC plays in KD susceptibility and our trial that aims toward the implementation of personalized medicine for KD.

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“…Moreover, KD is overrepresented in Asian children, with gender differences observed (boy:girl ratio of about 1.5:1) 6,7 . Annual incidence of KD in Taiwan is estimated to be 69/100 000 children, the third highest in the world after Japan and Korea 8,9 . The immune response is characterized by the accumulation and expansion of T-helper 1 (Th1) lymphocytes and increased amounts of several proinflammatory cytokines, such as interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α) and sex hormones [10][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

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Chena¹,

Lina²,

Chang³

et al. 2011

ScienceAsia

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Kawasaki disease (KD) is considered infectious, with immunologic expressions caused by genetic susceptibility of individuals. The 17β-hydroxysteroid dehydrogenase type 8 (17β-HSD8) enzymes are involved in the biosynthesis of oestrogens and androgens and regulate immune responses through hormonal modulation in mammals. To clarify the relationship between 17β-HSD8 gene single nucleotide polymorphisms (SNPs) and the pathogenesis of KD, we investigated association between 17β-HSD8 SNPs (rs421446, rs213213) and KD in Taiwanese children. Genotype analysis involved 93 KD patients and 680 unrelated healthy children. Our findings indicated the frequency of A allele in polymorphisms rs421446 was markedly higher among the patient group (43.3%) than in the control group (34.0%; p = 0.032). Children with the A allele at rs421446 SNP may show higher risk of developing KD, particularly those with AA homozygous genotype. From comparison of haplotype frequencies between case and control, children with AC haplotype appeared more "at-risk" for KD progression (p = 0.022). Our results suggest that rs421446 polymorphism and the haplotypes in 17β-HSD8 gene are associated with the risk of KD in Taiwanese children.

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Epidemiologic picture of Kawasaki disease in Korea, 2000–2002

Abstract: The average annual incidence, 86.4/100 000 in children <5 years old is the second highest rate in the world.

Cited by 41 publications

References 14 publications

HLA–E gene polymorphism associated with susceptibility to kawasaki disease and formation of coronary artery aneurysms

HLA–E gene polymorphism associated with susceptibility to kawasaki disease and formation of coronary artery aneurysms

Susceptibility genes for Kawasaki disease: toward implementation of personalized medicine

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