Epidemiologic patterns of Hodgkin's Disease

Abstract

The epidemiology mid histology of Hodgkin's disease in Cali, Colombia is reported on the basis of data from the Cancer Registry and a review of slides from several of the city's departments of pathology. Comparison of the results with incidence data published by UICC and with other reports on histologic subclassification has led to the identification of several epidemiologic patterns. Pattern I is characterized by high rates in children and predominance of histologic subtypes associated with poor prognosis. Pattern III is characterized by high rates in young adults and predominance of histologic subtypes associated with better prognosis. Pattern II is intermediate. These patterns are related to the economic stratification of the communities studied, and it is suggested that many of the epidemiological variegations of Hodgkin's disease may be explained on the basis of the interplay of environmental and host etiologic factors.

Epstein–Barr virus and Hodgkin’s disease: further evidence for the three disease hypothesis

“…1,2 In developed countries, the first peak in incidence occurs between the ages of 15 and 34 years, the incidence declines in the fourth decade and then peaks or plateaus above the age of 50 years. In contrast, in developing countries the first age incidence peak occurs in childhood, the young adult peak is absent or less pronounced and there is a second peak in the older adult age group.…”

“…In contrast, in developing countries the first age incidence peak occurs in childhood, the young adult peak is absent or less pronounced and there is a second peak in the older adult age group. 2,3 Intermediate patterns of age incidence curve have been described in rural areas and in countries undergoing socio-economic development. 2,4,5 The distribution of the histological subtypes of HD also varies with age; nodular sclerosis HD (HDNS) largely accounts for the young adult age incidence peak whereas the incidence of mixed cellularity HD (HDMC) increases with age and eventually exceeds that of HDNS.…”

“…2,3 Intermediate patterns of age incidence curve have been described in rural areas and in countries undergoing socio-economic development. 2,4,5 The distribution of the histological subtypes of HD also varies with age; nodular sclerosis HD (HDNS) largely accounts for the young adult age incidence peak whereas the incidence of mixed cellularity HD (HDMC) increases with age and eventually exceeds that of HDNS. 6,7 In comparison to young adult HD, HDMC is relatively more common than HDNS in childhood.…”

“…6,7 In comparison to young adult HD, HDMC is relatively more common than HDNS in childhood. 2,6 Lymphocyte-depleted (HDLD) and lymphocyte predominance HD (HDLP) account for only a small proportion of cases. HDLP is now considered to be a disease of B cell origin and is distinguished from other subtypes which are collectively referred to as classical HD.…”

Epidemiological study of socioeconomic factors and clinical findings in Hodgkin's disease, and reanalysis of previous data regarding chemical exposure

“…Twenty-five percent of elderly patients have only infradiaphragmatic lesions at diagnosis, compared with <5% of young adult patients (Li et al, 1973). Furthermore there is marked geographical variation in the age-incidence pattern of HD among the young but not among the elderly, and this variation has been related to socioeconomic factors (Correa & O'Conor, 1971). Different aetiology of HD has been suggested in young and elderly subjects.…”