Epidemiologic Features of Severe Fever With Thrombocytopenia Syndrome in China, 2011-2012

Ding, Fan; Zhang, Wenyi; Wang, Li Ya; Hu, Wenbiao; Magalhães, Ricardo J. Soares; Sun, Haiyan; Zhou, Hang; Sha, Sha; Li, Shenlong; Liu, Qiyong; Li, Qun; Yang, Weizhong; Huang, Liuyu; Li, Chengyi; Yin, Wenwu

doi:10.1093/cid/cit100

Cited by 110 publications

(91 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…SFTS patients have been identified in 16 provinces of east China [25] (Figure 2). SFTS has occurred most frequently in central China, especially in Henan, Hubei, and Shandong Province, which have reported 48.2%, 21.9%, and 15.7% of the total SFTS cases, respectively [26].…”

Section: Geographical Distribution and Seasonal Outbreaksmentioning

confidence: 99%

An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV

Zhang

Liu

Zhao

et al. 2013

Sci. China Life Sci.

View full text Add to dashboard Cite

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever in rural areas of China and is caused by a new bunyavirus, SFTSV, named after the disease. The transmission vectors and animal hosts of SFTSV are unclear. Ticks are the most likely transmission vectors and domestic animals, including goats, dogs, and cattle, are potential amplifying hosts of SFTSV. The clinical symptoms of SFTS are nonspecific, but major symptoms include fever, gastrointestinal symptoms, myalgia, dizziness, joint pain, chills, and regional lymphadenopathy. The most common abnormalities in laboratory test results are thrombocytopenia (95%), leukocytopenia (86%), and elevated levels of serum alanine aminotransferase, aspartate aminotransferase, creatine kinase, and lactate dehydrogenase. The fatality rate for SFTS is 12% on average, and the annual incidence of the disease is approximately five per 100000 of the rural population.

show abstract

Section: Geographical Distribution and Seasonal Outbreaksmentioning

confidence: 99%

An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV

Zhang

Liu

Zhao

et al. 2013

Sci. China Life Sci.

View full text Add to dashboard Cite

show abstract

“…This virus was named strain YG1 (7). Recently, SFTSV and other genetically related viruses that are pathogenic for humans have been reported in East Asia and North America (8)(9)(10)(11)(12)(13). However, their molecular biological characteristics and pathogenic mechanisms are not fully understood (5,14,15).…”

Section: Introductionmentioning

confidence: 99%

Establishment of Subclones of the Severe Fever with Thrombocytopenia Syndrome Virus YG1 Strain Selected Using Low pH-Dependent Cell Fusion Activity

et al. 2017

View full text Add to dashboard Cite

“…Since emerging in China in 2009, thousands of infections have been reported in humans throughout China, South Korea, and Japan. Upon zoonosis from ticks to humans, SFTSV causes thrombocytopenia, leukocytopenia, febrile illness, and in severe cases encephalitis (1)(2)(3). SFTSV belongs to the Bhanja phlebovirus serocomplex, and genomic analysis reveals that the virus has evolved extensively over the last 150 y, having diverged into at least five different clusters (4).…”

mentioning

confidence: 99%

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion

Halldorsson

Behrens

Harlos

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

An emergent viral pathogen termed severe fever with thrombocytopenia syndrome virus (SFTSV) is responsible for thousands of clinical cases and associated fatalities in China, Japan, and South Korea. Akin to other phleboviruses, SFTSV relies on a viral glycoprotein, Gc, to catalyze the merger of endosomal host and viral membranes during cell entry. Here, we describe the postfusion structure of SFTSV Gc, revealing that the molecular transformations the phleboviral Gc undergoes upon host cell entry are conserved with otherwise unrelated alpha-and flaviviruses. By comparison of SFTSV Gc with that of the prefusion structure of the related Rift Valley fever virus, we show that these changes involve refolding of the protein into a trimeric state. Reverse genetics and rescue of site-directed histidine mutants enabled localization of histidines likely to be important for triggering this pH-dependent process. These data provide structural and functional evidence that the mechanism of phlebovirushost cell fusion is conserved among genetically and pathophysiologically distinct viral pathogens.emerging virus | phlebovirus | viral membrane fusion | bunyavirus | structure

show abstract

Epidemiologic Features of Severe Fever With Thrombocytopenia Syndrome in China, 2011-2012

Cited by 110 publications

References 7 publications

An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV

An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV

Establishment of Subclones of the Severe Fever with Thrombocytopenia Syndrome Virus YG1 Strain Selected Using Low pH-Dependent Cell Fusion Activity

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion

Contact Info

Product

Resources

About