In these conditions of Covid-19 pandemic, the design and implementation of an epidemiological modeling platform with an API-type integration with beneficiary entities and data providers is a priority for the healthcare system and other organizations. An epidemiological platform (PLIS), replicable and adaptable for managing an epidemic, based on an integrated extended SIR-type model, is presented in this paper. This solution has an open architecture, respecting the scalability and interoperability, requirements, and is based on international communication standards and protocols, and SOA technology.