Epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations

Okeleji, L O; Ajayi, Ayodeji Folorunsho; Adebayo-Gege, Grace; Aremu, Victoria Oyetayo; Adebayo, Oluwadunsin Iyanuoluwa; Adebayo, Emmanuel Tayo

doi:10.1016/j.cdtm.2020.11.004

Cited by 7 publications

(6 citation statements)

References 75 publications

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“…A second key regulator is anti-apoptosis synuclein alpha ( SNCA ), which is related to Parkinson disease. However, SNCA also plays a role in the response to oxidative stress and has been related to lung function decline (Okeleji et al 2021); (Singhania et al 2018). A third key regulator is adiponectin receptor 1 ( ADIPOR1 ), which regulates fatty acid catabolism and glucose levels.…”

Section: Resultsmentioning

confidence: 99%

Predicting seasonal influenza vaccine response using systemic gene expression profiling

Gresham

Forst²,

Chung³

et al. 2022

Preprint

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Seasonal influenza is a primary public health burden in the USA and globally. Annual vaccination programs are designed on the basis of circulating influenza viral strains. However, the effectiveness of the seasonal influenza vaccine is highly variable between seasons and among individuals. A number of factors are known to influence vaccination effectiveness including age, sex, and comorbidities. Here, we sought to determine whether whole blood gene expression profiling prior to vaccination is informative about pre-existing immunological status and the immunological response to vaccine. We performed whole transcriptome analysis using RNA sequencing (RNAseq) of whole blood samples obtained prior to vaccination from participants enrolled in an annual influenza vaccine trial. Serological status prior to vaccination and 28 days following vaccination was assessed using the hemagglutination inhibition assay (HAI) to define baseline immune status and the response to vaccination. We find evidence that genes with immunological functions are increased in expression in individuals with higher pre-existing immunity and in those individuals who mount a greater response to vaccination. Using a random forest model we find that this set of genes can be used to predict vaccine response with a performance similar to a model that incorporates physiological and prior vaccination status alone. Our study shows that increased expression of immunological genes, possibly reflecting greater plasmablast cell populations, prior to vaccination is associated with an enhanced response to vaccine. Furthermore, in the absence of physiological information and vaccination history, whole blood gene expression signatures are informative about the immunological response of an individual to seasonal influenza vaccination.

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Section: Resultsmentioning

confidence: 99%

Predicting seasonal influenza vaccine response using systemic gene expression profiling

Gresham

Forst²,

Chung³

et al. 2022

Preprint

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“…UPF are nutritionally inferior, poor sources of essential nutrients such as antioxidants and rich in energy, sugary drinks, saturated and hydrogenated fats [43,44]. These products all cause systemic oxidative stress and breach immunological response [50], which could be the prime mechanism for the development of many non-communicable diseases [56,57], including CRDs and cancer. Epidemiological studies show that dietary antioxidants are paramount for respiratory epithelial cell integration and pulmonary function in antioxidant gene polymorphic forms [58,59].…”

Section: Potential Mechanismsmentioning

confidence: 99%

Ultra-processed food consumption and risk of chronic respiratory diseases mortality among adults: evidence from a prospective cohort study

Mekonnen,

Melaku,

Shi

et al. 2024

Eur J Nutr

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Purpose The purpose of the study was to determine the relationships between ultra-processed food (UPF) consumption and risk of mortality due to chronic respiratory diseases (CRDs) overall, chronic obstructive pulmonary disease (COPD), and lung cancer. Methods A total of 96,607 participants aged 55 years and over were included from the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer trial. Dietary intake was measured using food frequency questionnaire. Cox regression was fitted to estimate the risk of all-cause mortality and mortality due to CRDs overall, COPD and lung cancer associated with UPF intake. Competing risk regression was used to account for deaths from other causes and censoring. Results During the follow-up of 1,379,655.5 person-years (median 16.8 years), 28,700 all-cause, 4092 CRDs, 2015 lung cancer and 1,536 COPD mortality occurred. A higher intake of UPF increased the risk of mortality from CRDs overall by 10% (HR 1.10; 95% CI 1.01, 1.22) and COPD by 26% (HR 1.26; 95% CI 1.06, 1.49) but not associated with lung cancer mortality risk (HR 0.97; 95% CI 0.84, 1.12). However, the risk of lung cancer increased by 16% (HR 1.16; 95% CI 1.01, 1.34) in the highest UPF intake after multiple imputation. Dose–response relationships existed for CRDs and COPD mortality but not lung cancer. Conclusion UPF consumption was associated with an increased risk of CRD mortality. The association between UPF consumption and lung cancer mortality is inconclusive and only significant when multiple imputation was applied.

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“…Asthma is a complex condition that is heterogeneous and is characterized by the critical role of chronic airway inflammation and oxidative stress. The eosinophils, lymphocytes, neutrophils, and mast cells generate inflammatory mediators and ROS/RNS that negatively affect the redox balance [40,41]. Furthermore, these are the basis for identifying the actual Type 2 high and Type 2 low phenotypes [42].…”

Section: Asthmamentioning

confidence: 99%

Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases

Sierra-Vargas

Montero-Vargas

Debray-García

et al. 2023

IJMS

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Redox regulation participates in the control of various aspects of metabolism. Reactive oxygen and nitrogen species participate in many reactions under physiological conditions. When these species overcome the antioxidant defense system, a distressed status emerges, increasing biomolecular damage and leading to functional alterations. Air pollution is one of the exogenous sources of reactive oxygen and nitrogen species. Ambient airborne particulate matter (PM) is important because of its complex composition, which includes transition metals and organic compounds. Once in contact with the lungs’ epithelium, PM components initiate the synthesis of inflammatory mediators, macrophage activation, modulation of gene expression, and the activation of transcription factors, which are all related to the physiopathology of chronic respiratory diseases, including cancer. Even though the pathophysiological pathways that give rise to the development of distress and biological damage are not fully understood, scientific evidence indicates that redox-dependent signaling pathways are involved. This article presents an overview of the redox interaction of air pollution inside the human body and the courses related to chronic respiratory diseases.

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Epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations

Cited by 7 publications

References 75 publications

Predicting seasonal influenza vaccine response using systemic gene expression profiling

Predicting seasonal influenza vaccine response using systemic gene expression profiling

Ultra-processed food consumption and risk of chronic respiratory diseases mortality among adults: evidence from a prospective cohort study

Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases

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