Epidemiologic distribution of cancer in a 10-yearstudy: Retrospective review of hospital records and pathology centers of North Khorasan Province from 2003 to 2012

Abad, Maryam Seyyedi Nasooh; Gangy, R; Sharifian, E; Nikdel, R; Jafarzadeh, M; Jafarzadeh, Fatemeh

doi:10.29252/jnkums.6.4.689

Cited by 4 publications

(2 citation statements)

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“…Epidemiological studies indicate the significant prevalence of skin cancer and mortality in recent years (17). Melanoma, as serious skin cancer, develops in melanocytes.…”

Section: Discussionmentioning

confidence: 99%

Assessment the Effect of Ficus carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3 & Caspase-9 on Induction of Intrinsic Apoptosis Cascade

Sadeghizade

Baharara

Salek

et al. 2021

Jundishapur J Nat Pharm Prod

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Background: Melanoma is the most serious kind of skin cancer which has significantly increased in recent decades, and the importance of its primary treatment is increased widely. Ficus carica leaves have various therapeutic impact such as anti-inflammatory, anti-proliferative and apoptotic activity. Objectives: Hence, regarding the F. carica effect on the treatment of various diseases, the present research was conducted to identify the effect of methanolic extract of F. carica leaf on apoptosis induction in B16F10 melanoma cancer cells. Methods: Cell survival was estimated by MTT assay after treatment of B16F10 cells in various concentrations of F. carica leaf extract (150, 250, 350, 450, 550, 650, 750 and 850 μg /mL) for 24 and 48 h. Cell apoptosis was analysed by AO/PI and DAPI staining, Annexin V/Propidium Iodide flow cytometry. Moreover, Real-time PCR was utilized to evaluate the expression of apoptotic genes including p53, Bax, caspase-3 and caspase-9 genes. Results: MTT assay results indicated that methanolic extract of F. carica leaf prevented the proliferation of B16F10 cells in a dose and time dependent manner. AO/PI staining results showed an elevation in apoptotic cells in treated groups and DAPI indicated that F. carica extract resulted in chromatin condensation and fragmentation. Annexin V revealed the increasing percentage of apoptotic cells after treatment. In addition, the up-regulation of apoptotic genes confirmed the apoptosis inducing potential of F. carica leaves in B16F10 cells by Real-time PCR. Conclusions: Thus, methanolic extract of F. carica leaves could be suggested as an effective anti-cancer agent for further studies on melanoma cancer.

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“…Epidemiological studies indicate the significant prevalence of skin cancer and mortality in recent years (17). Melanoma, as serious skin cancer, develops in melanocytes.…”

Section: Discussionmentioning

confidence: 99%

Assessment the Effect of Ficus carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3 & Caspase-9 on Induction of Intrinsic Apoptosis Cascade

Sadeghizade

Baharara

Salek

et al. 2021

Jundishapur J Nat Pharm Prod

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show abstract

“…Globally, about 1 in 6 deaths is due to cancer [2]. Based on the latest statistical and epidemiological investigations in Iran, cancers are the third mortality cause in Iran after cardiovascular diseases and accident which lead to more than 98 daily deaths [3]. The most prevalent cancers in the world and in Iran were breast cancer, prostate cancer, gastrointestinal cancer, and head and neck cancers in 2012 [4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Patient Education on the Quality of Life Cancer Patients Undergoing Radiotherapy: A Review Article

Pashaie

Estebsari

Matbouei

et al. 2019

JPRI

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Background: Currently, cancer is a major problem of human societies. Different methods are used for cancer treatment including radiotherapy. Radiotherapy affects patients in different ways and makes changes to the quality of life of cancer patients undergoing radiotherapy. Objectives: The purpose of this article is to assess the effect of education on the quality of life of cancer patients undergoing radiotherapy. Methods: This is a review article with key words including “Education”, “Quality of life”, “Patients”, “Cancer”, and “Radiotherapy” in some Data bases such as Medline, Scopus, Science direct and Ovid during 2000 to 2019. Results: Of the 928 original articles, six papers were selected based on the main criteria, such as English and Persian language, articles of clinical relevance, and articles after 2000. In this study, articles were based on clinical trials on women and men patients with different cancers. Results of this study proved that education is the major component in improving these patients’ quality of life. Conclusion: Radiotherapy, alone or in combination with other therapeutic methods, is among main treatments of cancer patients. Despite its beneficial effects, it is associated with some side effects reducing the quality of life of these patients. Physical and mental complications were equally involved in reducing their quality of life. Based on this finding, it is suggested that the use of educational methods and training and rehabilitation programs can influence the quality of cancer patients treated with various methods, especially radiation therapy.

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The Epidemiological Survey of the Cancer Patients Referring to the Radiotherapy Center at Vali-e-Asr Teaching Hospital in Zanjan, Iran (2016-2018)

Chehre

Rezaeejam

Moghaddam

et al. 2019

J. Hum. Environ. Health Promot

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Epidemiologic distribution of cancer in a 10-yearstudy: Retrospective review of hospital records and pathology centers of North Khorasan Province from 2003 to 2012

Cited by 4 publications

References 0 publications

Assessment the Effect of Ficus carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3 & Caspase-9 on Induction of Intrinsic Apoptosis Cascade

Assessment the Effect of Ficus carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3 & Caspase-9 on Induction of Intrinsic Apoptosis Cascade

Evaluation of the Effect of Patient Education on the Quality of Life Cancer Patients Undergoing Radiotherapy: A Review Article

The Epidemiological Survey of the Cancer Patients Referring to the Radiotherapy Center at Vali-e-Asr Teaching Hospital in Zanjan, Iran (2016-2018)

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