Epidemiologic differences in esophageal cancer between Asian and Western populations

Zhang, Hanze; Jin, Guangfu; Shen, Hongbing

doi:10.5732/cjc.011.10390

Cited by 246 publications

(206 citation statements)

References 48 publications

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“…1,2 The 5-year survival rate of esophageal squamous cell carcinoma patients after surgery and chemotherapy remains low owing to highly invasive and metastatic nature of esophageal squamous cell carcinoma. Cancer stem-like cells are a small subpopulation within tumors with the capacities for self-renewal and generating heterogeneous tumor cell lineages.…”

mentioning

confidence: 99%

ALDH1A1 defines invasive cancer stem-like cells and predicts poor prognosis in patients with esophageal squamous cell carcinoma

et al. 2014

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Invasion and metastasis are the major cause of deaths in patients with esophageal cancer. In this study, we isolated cancer stem-like cells from an esophageal squamous cell carcinoma cell line EC109 based on aldehyde dehydrogenase 1A1 (ALDH1A1), and found that ALDH1A1 high cells possessed the capacities of self-renewal, differentiation and tumor initiation, indications of stem cell properties. To support their stemness, ALDH1A1 high cells exhibited increased potential of invasion and metastasis as compared with ALDH1A1 low cells. ALDH1A1 high esophageal squamous cell carcinoma cells expressed increased levels of mRNA for vimentin, matrix metalloproteinase 2, 7 and 9 (MMP2, MMP7 and MMP9), but decreased the level of E-cadherin mRNA, suggesting that epithelial-mesenchymal transition and secretary MMPs may be attributed to the high invasive and metastatic capabilities of ALDH1A1 high cells. Furthermore, we examined esophageal squamous cell carcinoma specimens from 165 patients and found that ALDH1A1 high cells were associated with esophageal squamous dysplasia and the grades, differentiation and invasion depth, lymph node metastasis and UICC stage of esophageal squamous cell carcinoma, as well as poor prognosis of patients. Our results provide the strong evidence that ALDH1A1 high cancer stem-like cells contribute to the invasion, metastasis and poor outcome of human esophageal squamous cell carcinoma. Modern Pathology (2014) 27, 775-783; doi:10.1038/modpathol.2013.189; published online 8 November 2013Keywords: aldehyde dehydrogenase 1A1; cancer stem-like cells; esophageal squamous carcinoma; invasion; metastasis; prognosis Esophageal squamous cell carcinoma is one of the most frequent fatal malignancies in the area from northern Iran to north-central China ('Asian esophageal cancer belt'). 1,2 The 5-year survival rate of esophageal squamous cell carcinoma patients after surgery and chemotherapy remains low owing to highly invasive and metastatic nature of esophageal squamous cell carcinoma. Cancer stem-like cells are a small subpopulation within tumors with the capacities for self-renewal and generating heterogeneous tumor cell lineages. 3 Recent studies suggest that cancer stem-like cells are responsible for invasion and metastasis of many tumor types. We have reported that cancer stem-like cells possess higher capability of invasion and metastasis in solid tumors. [4][5][6] However, the biomarkers related to invasion and metastasis of cancer stem-like cells

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confidence: 99%

ALDH1A1 defines invasive cancer stem-like cells and predicts poor prognosis in patients with esophageal squamous cell carcinoma

et al. 2014

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“…However, squamous cell cancer continues to be the major type of esophageal cancer in Asia. In contrast, adenocarcinoma predominately affects the Caucasian population in Western countries, these two different diseases might need different staging systems, this however is not studied and remains unknown today (37,38). The location of the primary tumor and histopathologic cell type both influence the location of lymph node metastases, resulting in a different surgical approach and lymphadenectomy (39).…”

Section: Lymph Node Classification Systemsmentioning

confidence: 99%

The extent of lymphadenectomy in esophageal resection for cancer should be standardized

et al. 2017

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The incidence of esophageal cancer increases, with approximately 482,000 patients diagnosed with esophageal cancer each year. Despite the growing incidence of esophageal carcinoma, the extent of the lymphadenectomy is still under discussion. Lymph node status is an important prognostic parameter in esophageal cancer and an independent predictor of survival. Surgical strategy depends on the distribution pattern of nodal metastases but consensus on the extent of lymphadenectomy differs worldwide. For squamous cell cancer, Japanese surgeons have standardized the 2-or 3-field lymphadenectomy according to the location of the tumor. For adenocarcinoma, in the Western World accounting for 85% of all esophageal cancers, the type of lymphadenectomy to perform is not clear. Moreover, the use of neoadjuvant therapy may influence the mediastinal lymph nodes and the significance of the lymphadenectomy for survival. These aspects have challenged the traditional policy concerning lymphadenectomy, at least in the Western World. Furthermore, an extensive lymphadenectomy may improve survival but, on the other hand, may cause significant more morbidity. An overview of the literature on the extent of lymphadenectomy for esophageal cancer with respect to the supposed lymph node distribution patterns for squamous cell carcinoma and adenocarcinoma, the different lymph node classification systems, the commonly used surgical techniques and outcomes, and the proposal of observational cohort study to standardize the type of lymphadenectomy according to the type of tumor, location and use of neoadjuvant therapy will be provided.

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“…The signs and symptoms of ESCC are found in the final stage, so mortality is very high. Meanwhile, nearly 40 percent of patients with ESCC significant was found the phenomenon familial aggregation (Zhang et al, 2012). In this study, to clarify the role of STK15 in ESCC of Mongolian population, we performed association studies between 2 nonsynonymous in the coding region of STK15, Phe31Ile (dBSNP reference rs2273535 T/A) and Val57Ile (dBSNP Guang-Lie Chen et al reference rs1047972 G/A) and ESCC.…”

Section: Upregulation Of Stk15 In Esophageal Squamous Cell Carcinomasmentioning

confidence: 99%

Upregulation of STK15 in Esophageal Squamous Cell Carcinomas in a Mongolian Population

Guanglie

Hou²,

Sun³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Epidemiologic differences in esophageal cancer between Asian and Western populations

Cited by 246 publications

References 48 publications

ALDH1A1 defines invasive cancer stem-like cells and predicts poor prognosis in patients with esophageal squamous cell carcinoma

ALDH1A1 defines invasive cancer stem-like cells and predicts poor prognosis in patients with esophageal squamous cell carcinoma

The extent of lymphadenectomy in esophageal resection for cancer should be standardized

Upregulation of STK15 in Esophageal Squamous Cell Carcinomas in a Mongolian Population

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