Epidemiologic Characteristics, Predisposing Factors, and Etiologic Diagnosis of Corneal Ulceration in Nepal

Upadhyay, Madan Prasad; Karmacharya, P C; Koirala, Soniya; Tuladhar, Nhuchhe Ratna; Bryan, L. E.; Smolin, Gilbert; Whitcher, John P.

doi:10.1016/s0002-9394(14)76903-x

Cited by 271 publications

(261 citation statements)

References 14 publications

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“…Cases of paediatric bacterial keratitis have been reported in children with the age of 1 month and onwards by various authors. 12,13 In the present study, bacterial keratitis was found to occur more frequently in boys than in girls. Kunimoto et al 1 did not identify unequal gender distribution in paediatric microbial keratitis cases, whereas Cruz et al 5 have found a male preponderance.…”

Section: Discussionsupporting

confidence: 44%

Paediatric bacterial keratitis cases in Shanghai: microbiological profile, antibiotic susceptibility and visual outcomes

Hong

Chen

Sun

et al. 2012

Eye

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Purpose The purpose of this study was to review the microbiological profile, in vitro antibiotic susceptibility and visual outcomes of paediatric microbial keratitis in Shanghai, China over the past 6 years. Methods Medical records of patients aged r16 years were reviewed, who were diagnosed as having bacterial keratitis between 1 January 2005 and 31 December 2010. Bacterial culture results and in vitro antibiotic susceptibility were analysed. A logistic regression analysis was conducted to evaluate the relationship between visual impairment and possible risk factors. Results Eighty consecutive cases of paediatric bacterial keratitis cases were included, among which 59 were identified as having positive culture. Staphylococcus epidermidis was the most commonly isolated organism (n ¼ 23; 39.0%), followed by Streptococcus pneumoniae (n ¼ 11; 18.6%) and Pseudomonas aeruginosa (n ¼ 6; 10.2%). Antibiotic sensitivities revealed that tested bacteria had low resistance rates to fluoroquinolones and aminoglycosides (8.3-18.4% and 12.5-24.4%, respectively). Multivariate logistic regression analysis proved that visual impairment was significantly associated with Gram-negative bacterial infection (odds ratio (OR) ¼ 7.626; P ¼ 0.043) and an increasing number of resistant antibiotics (OR ¼ 0.385; P ¼ 0.040). Conclusions S. epidermidis was the most common isolated organism in Shanghai paediatric keratitis. The fluoroquinolones and aminoglycosides remained good choices for treating these patients. Gram-negative bacterial infection and an increasing number of resistant antibiotics were associated with worse visual prognoses in paediatric keratitis.

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Section: Discussionsupporting

confidence: 44%

Paediatric bacterial keratitis cases in Shanghai: microbiological profile, antibiotic susceptibility and visual outcomes

Hong

Chen

Sun

et al. 2012

Eye

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“…The Nepal national blindness survey conducted in the year 1981 has revealed 2.4% of the populations were monocular blind due to eye injury. Tribhuwan University Teaching Hospital (TUTH) study showed 21.1% and the Bhaktapur eye survey showed 0.7 % of [7][8] blindness due to trauma. Eye trauma in childhood and its 2 adnexa represent approximately 4-20% of all eye injuries.…”

Section: Methodsmentioning

confidence: 99%

Spectrum of Ocular Trauma Among Children in Tertiary Eye Hospital of Nepal

Kafle

Shrestha

2017

Birat J. Health Sci.

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“…Corneal infections are one of the leading causes of ocular morbidity and blindness world-wide (Saha and Das, 2006;Iyer et al, 2006;Upadhyay et al, 1991;Srinivasan, 2004). Most of the pathogens cause ulceration of the cornea; which if not accurately diagnosed in time, may be devastating.…”

Section: Introductionmentioning

confidence: 99%

“…Middle-aged men are more commonly affected. Trauma with vegetative matter serves as the most important predisposing factor for mycotickeratitis (Saha and Das, 2006;Lisa et al, 2011;Upadhyay et al, 1991).…”

Section: Introductionmentioning

confidence: 99%