Epidemiologic Characteristics and Risk Factors for Congenital Hypothyroidism from 2009 to 2018 in Xiamen, China

Chen, Jing; Lin, Shaowu; Zeng, Guozhang; Wang, Weixing; Lin, Zhenqiu; Xu, Chao; He, Ying; Shi, Jonathan; Zhou, Xianghui; Niu, Conway; Che, Lin

doi:10.4158/ep-2019-0491

Cited by 12 publications

(16 citation statements)

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“…Female predominance in our study (1.4 to 1) was in accordance with previous studies (19,34) and opposite to first report by Zeinalzadeh and Talebi from East-Azarbaijan, Iran (36). Interpretation of gender differences in our study with contrasting past studies could not be accurate as our sample size was too small.…”

Section: Discussionsupporting

confidence: 60%

“…The prevalence of CH in EMRO region was 1:2934 live births in Turkey (9), 1:3292 in Saudi Arabia (20). In the eastern region of Asia was 1:1136 in Japan (31), 1:1992 in Taiwan (19), and 1:764 in Mongolia (32). In Europe, from 1:1800 live births in Greek Cypriots (33) to 1:1970 in Italy (1).…”

Section: Discussionmentioning

confidence: 99%

“…Although the higher ratio of transient hypothyroidism due to iodine deficiency (17,19) and consanguineous parents (4,20) partly explained incidence rate in our country, timely diagnosis and treatment even in transient cases are mandatory to prevent growth and neurodevelopmental defects. If thyroid hormone deficiency remains unrecognized and untreated for more than 2 weeks after birth, can lead to permanent mental retardation, higher risk of other congenital anomalies, metabolic disruptions and consequently severe social and economic burden on the family and the society (5,6,18,21,22).…”

Section: Introductionmentioning

confidence: 89%

“…In 1972, the initial revision of the test and its questions was carried out and then translated and evaluated by Iranian researchers in a package in 1992, revised thereafter and is still used in Iran for children. WISC could be performed from minimum 3 years of age, for preschooler (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) and adults (26). Besides, WISC also has been used as health screening for readiness to enter primary school at six years of age.…”

Section: Methodsmentioning

confidence: 99%

“…Altogether, estimation of CH prevalence based on such studies could be biased (10,18). Alongside this, a remarkable proportion of the world lack a screening program (4,5,18) or have a poor newborn screening (NBS) coverage or imprecise health information system (4,19).…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of neonatal screening for congenital hypothyroidism

et al. 2021

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Introduction: Congenital hypothyroidism (CH) is the most common preventable cause of mental retardation. Newborn screening program considerably increases probability of CH diagnosis and treatment. Objectives: We aimed to investigate the efficacy of running CH screening program to maintain normal IQ and physical growth of hypothyroid children in Semnan city. Patients and Methods: This study was performed on children with definite CH who were treated and followed up in Semnan health centers. Around 41 children born within 2008-2013 (minimum three years of age) participated. Respective weight and height for age were measured. The Z-scores were calculated based on the WHO-Anthro-Anthro Plus Software. Intelligence Quotient (IQ) was measured with Wechsler Intelligence Score for children-revised (WISC-R). Data analyzed with one-tailed t test compared with age and gender-matched group. Results: The mean IQ Score in our study group was 90.09 (1.73) with no significant difference compared to healthy counterparts (P > 0.05). Z-score for weight and height was -0.46 and -0.45 prospectively and was not significantly different from normal children. Conclusion: Newborn screening program for CH has been effective in preventing mental retardation and growth failure.

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Section: Discussionsupporting

confidence: 60%