Epidemiologic aspects of Crohn's disease: a population based study in Olmsted County, Minnesota, 1943-1982.

Gollop, J H; Phillips, Sidney F.; Melton, L. Joseph; Zinsmeister, Alan R.

doi:10.1136/gut.29.1.49

Cited by 231 publications

(116 citation statements)

References 41 publications

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“…In accordance with descriptions claiming that Crohn’s disease is observed more frequently among urban dwellers of high socioeconomic level [30, 33, 34], a strong relationship between high educational level and urban residency was observed in our series. In 1981, the proportion of the population with a university degree in the whole of Greece was 4%.…”

Section: Discussionsupporting

confidence: 77%

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Clinical Patterns of Crohn’s Disease in Greece: A Follow-Up Study of 155 Cases

Triantafillidis

Emmanouilidis²,

Manousos³

et al. 2000

Digestion

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The aim of this prospective study was to elucidate the clinical features and natural history of Crohn’s disease in Greece. One hundred and fifty-five Greek patients with definite diagnosis of Crohn’s disease were followed-up for a mean period of 9.7 years and evaluated for clinical patterns and course of illness. The male/female ratio was 1.58:1. The peak incidence of the disease was observed between 20 and 30 years of age. The majority of patients were urban dwellers and of higher socio-economic level compared to the general population of Greece. In almost 50% of the patients symptoms of the disease started below the age of 30, although in almost one in every 5 cases, symptoms appeared after the age of 50. Familial clustering of inflammatory bowel disease was observed in 1.3%. The pattern of anatomic involvement was: ileocolic 33.3%, colon 33.3% and small bowel 33.3%. The kind of predominant symptoms at the time of diagnosis was related to the anatomic location of the disease. At least one extraintestinal manifestation appeared in 42% of patients. Perianal disease was noticed in 21.3% with fistulae and abscesses being the most common manifestation. Fifty-one percent of patients were operated upon at least once during the follow-up period because of acute abdomen, bad response to conservative treatment and fistulae and abscesses. Emergency operation was required in 17.3% of the patients. Evolution to cancer was observed in 3 patients (2%). During the follow-up period of 9.7 ± 6.5 years, 18 patients (11.6%) died. A considerable mortality was noticed in the surgically treated group of patients, while in the nonoperated group the disease was running with milder symptoms. It is concluded that some of the clinicoepidemiological characteristics of patients with Crohn’s disease in Greece are in accordance with those reported from western as well as the neighboring Mediterranean countries. However, other parameters such as the higher incidence of the disease in males, the low incidence of familial clustering, and the low incidence of perianal disease, underline the importance of environmental, genetic and other factors on the evolution and behavior of the disease in different parts of the world.

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Section: Discussionsupporting

confidence: 77%

“…So, the ages at onset of symptoms and at diagnosis were similar to those reported from developed and developing countries [2, 33, 34]. However, no bimodal age distribution was observed.…”

Section: Discussionsupporting

confidence: 66%

Clinical Patterns of Crohn’s Disease in Greece: A Follow-Up Study of 155 Cases

Triantafillidis

Emmanouilidis²,

Manousos³

et al. 2000

Digestion

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“…The inflammatory bowel diseases, Crohn's disease (CD) and ulcerative colitis (UC), are chronic, inflammatory diseases of the intestines with a combined prevalence of 200-300͞100,000 in the United States (1)(2)(3). CD may involve any part of the gastrointestinal tract (most frequently the terminal ileum and colon) (4).…”

mentioning

confidence: 99%

Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: Evidence for epistasis between 1p and IBD1

Cho

Nicolae

Gold

et al. 1998

Proc. Natl. Acad. Sci. U.S.A.

362

255

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The idiopathic inf lammatory bowel diseases, Crohn's disease (CD) and ulcerative colitis (UC), are chronic, frequently disabling diseases of the intestines. Segregation analyses, twin concordance, and ethnic differences in familial risks have established that CD and UC are complex, nonMendelian, related genetic disorders. We performed a genome-wide screen using 377 autosomal markers, on 297 CD, UC, or mixed relative pairs from 174 families, 37% Ashkenazim. We observed evidence for linkage at 3q for all families (multipoint logarithm of the odds score (MLod) ‫؍‬ 2.29, P ‫؍‬ 5.7 ؋ 10 ؊4 ), with greatest significance for non-Ashkenazim Caucasians (MLod ‫؍‬ 3.39, P ‫؍‬ 3.92 ؋ 10 ؊5 ), and at chromosome 1p (MLod ‫؍‬ 2.65, P ‫؍‬ 2.4 ؋ 10 ؊4 ) for all families. In a limited subset of mixed families (containing one member with CD and another with UC), evidence for linkage was observed on chromosome 4q (MLod ‫؍‬ 2.76, P ‫؍‬ 1.9 ؋ 10 ؊4 ), especially among Ashkenazim. There was confirmatory evidence for a CD locus, overlapping IBD1, in the pericentromeric region of chromosome 16 (MLod ‫؍‬ 1.69, P ‫؍‬ 2.6 ؋ 10 ؊3 ), particularly among Ashkenazim (MLod ‫؍‬ 1.51, P ‫؍‬ 7.8 ؋ 10 ؊3 ); however, positive MLod scores were observed over a very broad region of chromosome 16. Furthermore, evidence for epistasis between IBD1 and chromosome 1p was observed. Thirteen additional loci demonstrated nominal (MLod > 1.0, P < 0.016) evidence for linkage. This screen provides strong evidence that there are several major susceptibility loci contributing to the genetic risk for CD and UC.

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“…IBD incidence has traditionally been highest in North America and Europe (Gollop et al 1988); however, there has been an increase in the global incidence documented beginning approximately in the middle of the 20th century (Molodecky et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Murine Models of Inflammatory Bowel Disease (IBD)

DeVoss¹,

Diehl²

2013

Toxicol Pathol

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Animal models of human disease are a critical tool in both basic research and drug development. The results of preclinical efficacy studies often inform progression of therapeutic candidates through the drug development pipeline; however, the extent to which results in inflammatory bowel disease (IBD) models predict human drug response is an ongoing concern. This review discusses how murine models are currently being used in IBD research. We focus on the considerations and caveats for commonly used models in preclinical efficacy studies and discuss the value of models that utilize specific pathogenic pathways of interest rather than model all aspects of human disease.

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Epidemiologic aspects of Crohn's disease: a population based study in Olmsted County, Minnesota, 1943-1982.

Cited by 231 publications

References 41 publications

Clinical Patterns of Crohn’s Disease in Greece: A Follow-Up Study of 155 Cases

Clinical Patterns of Crohn’s Disease in Greece: A Follow-Up Study of 155 Cases

Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: Evidence for epistasis between 1p and IBD1

Murine Models of Inflammatory Bowel Disease (IBD)

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