1979
DOI: 10.1002/jso.2930120403
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Epidemiologic aspects of american kaposi's sarcoma

Abstract: In our series of 37 patients with Kaposi's sarcoma, a larger than expected incidence of Americans of Italian and Jewish lineage was found, with 51% of Italian and 38% of Jewish background. Although a predominance of these two groups has been clearly shown previously, this may be the highest percentage of any series. In addition, 12, or 32%, of the patients were found to have concurrent diabetes mellitus. This association has been observed previously, but is not generally appreciated.

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Cited by 56 publications
(24 citation statements)
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“…Even though only two cases of KS were found among 5692 Scandinavian renal transplant recipients in a recent study (Birkeland et al, 1995), iatrogenic immune suppression, such as in organ transplant recipients, remains a well-established risk factor for KS (Kinlen, 1982;Penn, 1983;Quibini et al, 1988). Similarly, systemic corticosteroid treatment has been suggested to confer an increased risk of KS in non-transplant recipients (Klepp et al, 1978 (Laor and Schwartz, 1979;Friedman-Birnbaum et al, 1990;Kaldor et al, 1994;Grulich et al, 1992;DiGiovanna and Safai, 1981). Although an excess of immigrants has been observed among Danish patients with non-AIDS-related KS in the period (Hjalgrim et al, 1996), less than 5% of the Swedish and Norwegian cases of KS were diagnosed in persons of foreign descents (Dictor and Attewell, 1988;Harvei et al, 1990).…”
Section: Resultsmentioning
confidence: 99%
“…Even though only two cases of KS were found among 5692 Scandinavian renal transplant recipients in a recent study (Birkeland et al, 1995), iatrogenic immune suppression, such as in organ transplant recipients, remains a well-established risk factor for KS (Kinlen, 1982;Penn, 1983;Quibini et al, 1988). Similarly, systemic corticosteroid treatment has been suggested to confer an increased risk of KS in non-transplant recipients (Klepp et al, 1978 (Laor and Schwartz, 1979;Friedman-Birnbaum et al, 1990;Kaldor et al, 1994;Grulich et al, 1992;DiGiovanna and Safai, 1981). Although an excess of immigrants has been observed among Danish patients with non-AIDS-related KS in the period (Hjalgrim et al, 1996), less than 5% of the Swedish and Norwegian cases of KS were diagnosed in persons of foreign descents (Dictor and Attewell, 1988;Harvei et al, 1990).…”
Section: Resultsmentioning
confidence: 99%
“…Classic KS, which appears in the apparent absence of immunosuppression, occurs predominantly on the lower extremities of elderly men, a common site of poor circulation in the elderly. There is also an association of KS with diabetes, which is known to cause circulatory problems (19,33). In addition, KS occurs on the skin, another site where hypoxic conditions have been measured (2), and KS has been described at the site of a surgical wound, yet another hypoxic tissue (62).…”
Section: Discussionmentioning
confidence: 99%
“…Although there are reports that advanced KS may involve a monoclonal proliferation, 42 the best available evidence suggests that spindle cell proliferation induced directly and/or indirectly by KSHV-encoded genes plays an important role in the development and progression of this condition. [43][44][45] Hypoxia-induced KSHV reactivation may contribute to the increased prevalence of KS in patients with diabetes mellitus, 46,47 as this condition is often associated with vascular disease and poor circulation. It may also contribute to the tendency of KS to occur on the lower legs, especially in the elderly men who develop classic KS.…”
Section: Discussionmentioning
confidence: 99%