Epidemiologic and virologic characteristics of hepatitis B virus genotype B having the recombination with genotype C

Sugauchi, Fuminaka; Orito, Etsuro; Ichida, Takafumi; Kato, Hideaki; Sakugawa, Hiroshi; Kakumu, Shinichi; Ishida, Takafumi; Chutaputti, Anuchit; Lai, Ching–Lung; Gish, Robert G.; Ueda, Ryuzo; Miyakawa, Yuzo; Mizokami, Masashi

doi:10.1053/gast.2003.50140

Cited by 202 publications

(228 citation statements)

References 35 publications

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“…HBV/B1 and HBV/B5 can therefore be thought of as 'pure' genotype B, a non-recombinant group, while subgenotype HBV/B2-B4 are a recombinant group, clustering closer with genotype C [76]. It has also been shown that subgenotypes HBV/B2-B4 contain genomic sequence corresponding to HBV/C, which includes the core promoter, precore, and core regions [79].…”

Section: Hbv Epidemiologymentioning

confidence: 99%

Serological and molecular epidemiological outcomes after two decades of universal infant hepatitis B virus (HBV) vaccination in Nunavut, Canada

Huynh¹,

Minuk

Uhanova

et al. 2017

Vaccine

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Section: Hbv Epidemiologymentioning

confidence: 99%

Serological and molecular epidemiological outcomes after two decades of universal infant hepatitis B virus (HBV) vaccination in Nunavut, Canada

Huynh¹,

Minuk

Uhanova

et al. 2017

Vaccine

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“…In contrast to the findings of the above studies in Vietnamese, a study by Song et al reported that genotype A was very commonly observed in HBV-infected Vietnamese patients (98.7%), that the pre-core mutation (G1896A) was not found, and dual core promoter mutations (A1762T/G1764A) were very rare in HCC patients (8%) and were not found in LC patients, CH patients or asymptomatic carriers (ASC) (33). The results reported by Song et al were very surprising, since the results of many other studies in East Asia and some in Vietnam, with only the exception of studies in the Philippines, showed that genotypes B and C were the major HBV genotypes in this region and mutations in the core promoter and pre-core regions were frequently found (8)(9)(10)(12)(13)(14)(15)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(34)(35)(36)(37)(38).…”

Section: Introductionmentioning

confidence: 95%

“…In East Asia, HBV genotypes B and C prevail, and recently these genotypes have been divided into sub-genotypes (8)(9)(10). Genotype B is classified into Bj and Ba (8,9); while genotype C is divided into Cs and Ce (10), and these sub-genotypes have different geographical distribution. The HBV genotype has an effect on long-term clinical outcome (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

“…The ELISA method with monoclonal antibodies was carried out in cases in which the genotype was not determined by RFLP (40). In addition, genotype B was sub-classified into Ba or Bj according to the method of Sugauchi et al (9). The quantitation of HBV-DNA level was determined by real-time PCR with a set of primers and Taq Man probe located in the S gene as previously reported (41).…”

Section: Introductionmentioning

confidence: 99%

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Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam

Truong

Seo²,

Yano³

et al. 2007

Int J Mol Med

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Abstract.Vietnam is one of the countries with a high rate of hepatitis B virus (HBV) infection, but there are only a few reports about relation of HBV genotypes and mutations to clinical course in Northern Vietnam. The characteristics of HBV and its relationship to clinical outcome in patients from Northern Vietnam were analyzed. Serum samples were collected from 183 HBV-infected Vietnamese patients. They were clinically categorized into 4 groups: hepatocellular carcinoma (HCC), liver cirrhosis (LC), chronic hepatitis (CH), and asymptomatic carriers (ASC). HBV serology, ·-fetoprotein, HBV genotypes, HBV-DNA level and mutations in the core promoter and pre-core regions of HBV-DNA were examined. The majority of sera contained HBV genotype B (67.8%) and C (27.9%). The median age was matched between genotype B and C (38.2 vs. 42.9 years). The rates of HBeAg seroconversion and G1896A for genotype B were significantly higher than those for genotype C (P<0.05). Genotype C had a higher HBV-DNA level than genotype B. C1858 was frequent, especially in genotype C (62.7%). The most prevalent genotype in ASC and CH was genotype B. The presence of the mutation A1762T/G1764A correlated with disease progression. The triple mutation T1753C/A1762T/ G1764A was quite common and was more prevalent in LC and HCC than in CH and ASC. In Northern Vietnamese, HBV genotypes B and C were prevalent. Genotype C and mutations in the core promoter region were associated with progressive, severe liver diseases.

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“…We compared the precore and core sequences of our five clones from the Philippines and four previous isolates from subgenotypes B1-B4 with HBV/C and HBV/B1 by following the method of Sugauchi et al (2002Sugauchi et al ( , 2003. The GenBank accession numbers and the countries from which they were derived are as follows: HBV/C, AB014378 (Japan) and D23684 (Japan); HBV/B1, AB073845 (Japan) and AB073855 (Japan).…”

mentioning

confidence: 99%

Analysis of the entire nucleotide sequence of hepatitis B virus genotype B in the Philippines reveals a new subgenotype of genotype B

Nagasaki

Niitsuma

Cervantes

et al. 2006

Journal of General Virology

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The entire nucleotide sequences were determined for hepatitis B virus (HBV) genotype B (HBV/B) genomes extracted from five patients in the Philippines and designated GenBank AB219426, AB219427, AB219428, AB219429 and AB219430. The serotype of the first four isolates was ayw and that of GenBank AB219430 was adw. Divergences of entire sequences were 1?0-2?0 % between the first four isolates and 3?8-4?2 % between these four and GenBank AB219430. Phylogenetic-tree analysis revealed that, worldwide, HBV/B comprises five subgenotypes: B1, B2, B3, B4 and the new Philippines group, designated B5. Divergences of the entire genome sequences between four isolates in subgenotype B5 and isolates from other countries (subgenotypes) were 4?4-4?8 % with Vietnam (B4), 2?9-3?5 % with Indonesia (B3), 4?7-5?1 % with China (B2) and 5?4-6?0 % with Japan (B1). Similarly, GenBank AB219430 showed the lowest divergences: 3?4 % with the isolate from Indonesia (B3), 5?0 % with Vietnam (B4), 5?4 % with China (B2) and 6?1 % with Japan (B1). This is the first report of entire nucleotide sequences of HBV/B from the Philippines and the results show that these sequences belong to a new subgenotype, B5. The present study identified that HBV/B isolates throughout the world are divided genetically into five subgenotypes, the relationships between geographical distances and the genetic distances of HBV/B being well-correlated.

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Epidemiologic and virologic characteristics of hepatitis B virus genotype B having the recombination with genotype C

Cited by 202 publications

References 35 publications

Serological and molecular epidemiological outcomes after two decades of universal infant hepatitis B virus (HBV) vaccination in Nunavut, Canada

Serological and molecular epidemiological outcomes after two decades of universal infant hepatitis B virus (HBV) vaccination in Nunavut, Canada

Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam

Analysis of the entire nucleotide sequence of hepatitis B virus genotype B in the Philippines reveals a new subgenotype of genotype B

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