Epidemiologic and Clinical Characteristics of Bartonella quintana and Bartonella henselae Endocarditis

Fournier, Pierre‐Edouard; Lelièvre, Hélène; Eykyn, Susannah J.; Mainardi, Jean–Luc; Marrie, Thomas J.; Bruneel, Fabrice; Roure, C.; Nash, James; Clave, D.; James, Edward; Benoit-Lemercier, Catherine; Deforges, Lionel; Tissot‐Dupont, Hervé; Raoult, Didier

doi:10.1097/00005792-200107000-00003

Cited by 223 publications

(226 citation statements)

References 51 publications

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“…For our patients, the common predisposing factors were poor hygiene and low socioeconomic status, which may expose them to ectoparasites including lice and fl eas. In contrast with previous study fi ndings, B. quintana infectious endocarditis developed on preexisting valvular lesions in all patients (10). This fi nding may refl ect a different clinical evolution than in Europe, where studies have suggested that B. quintana infectious endocarditis followed chronic bacteremia in patients who did not have previous valvular defects (10).…”

contrasting

confidence: 87%

Bartonella quintanaandCoxiella burnetiias Causes of Endocarditis, India

Balakrishnan

Menon

Fournier

et al. 2008

Emerg. Infect. Dis.

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contrasting

confidence: 87%

Bartonella quintanaandCoxiella burnetiias Causes of Endocarditis, India

Balakrishnan

Menon

Fournier

et al. 2008

Emerg. Infect. Dis.

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“…(Rochalimaea) henselae [101]. Bartonella species, mainly B. quintana and B. henselae, account for approximately 3% of human endocarditis cases, with more than 100 human cases reported in the international literature since 1993 [85,189,190]. In most human cases of Bartonella endocarditis, the vegetative lesions are preferentially located on the aortic valve [189] and most patients have high antibody titers [86].…”

Section: Humansmentioning

confidence: 99%

“…In most human cases of Bartonella endocarditis, the vegetative lesions are preferentially located on the aortic valve [189] and most patients have high antibody titers [86]. Furthermore, most cases of B. henselae endocarditis are culture negative but positive by DNA amplification [85]. Bartonella henselae and B. quintana DNA were also detected in the cardiac tissue of four young Swedish orienteers who died of unexpected sudden cardiac death [229].…”

Section: Humansmentioning

confidence: 99%

Factors associated with the rapid emergence of zoonotic Bartonella infections

et al. 2005

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-The present manuscript reviews the factors associated with the emergence of these zoonotic pathogens, including better diagnostic tools and methods to identify these fastidious bacteria, host immunosuppression (caused by infectious agents, cancer, aging or induced by immunosuppressive drugs), the interaction of co-infection by several infectious agents that may enhanced the pathogenecity of these bacteria, increased outdoor activity leading to exposure to wildlife reservoirs or vectors, poverty and low income associated with infestation by various ectoparasites, such as body lice and finally the dispersal of Bartonellae around the world. Furthermore, a description of the main epidemiological and clinical features of zoonotic Bartonellae is given. Finally, the main means for diagnosis, treatment and prevention of these diseases are presented.

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“…In these patients, Bartonella henselae can develop bacillary angiomatosis (BA) or peliosis (BP), vasoproliferative tumour lesions of the skin or the inner organs, respectively (Mosepele et al, 2012;Relman et al, 1990), which derive from bacterial colonization and activation of human ECs inducing bacteraemia and fever of unknown cause (Chomel et al, 2009). In addition, Bartonella henselae, as also Bartonella quintana, causes blood-culture-negative endocarditis (BCNE), as indicated by its isolation from native aortic valve tissue of people affected by infectious endocarditis (IE) (Fournier et al, 2001;González et al, 2014;Katsouli & Massad, 2013;Lamas et al, 2013;Que & Moreillon, 2011). Furthermore, because of the negativity of the blood culture, the diagnosis of BCNE is usually considerably delayed; this could be the reason why most patients present acute cardiac failure, cardiac murmur, dyspnoea and bibasilar rales, thus suggesting global cardiac failure (Brouqui & Raoult, 2001;Dimopoulos et al, 2012).…”

Section: Bartonella Henselae: Mechanisms Of Infection and Cardiovascumentioning

confidence: 99%

Infections and cardiovascular disease: is Bartonella henselae contributing to this matter?

Salvatore

Zullo

Sommese

et al. 2015

Journal of Medical Microbiology

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Infections and cardiovascular disease: is Bartonella henselae contributing to this matter? Cardiovascular disease is still the major cause of death worldwide despite the remarkable progress in its prevention and treatment. Endothelial progenitor cells (EPCs) have recently emerged as key players of vascular repair and regenerative medicine applied to cardiovascular disease. A large amount of effort has been put into discovering the factors that could aid or impair the number and function of EPCs, and also into characterizing these cells at the molecular level in order to facilitate their therapeutic applications in vascular disease. Interestingly, the major cardiovascular risk factors have been associated with reduced number and function of EPCs. The bacterial contribution to cardiovascular disease represents a long-standing controversy. The discovery that Bartonella henselae can infect and damage EPCs revitalizes the enduring debate about the microbiological contribution to atherosclerosis, thus allowing the hypothesis that this infection could impair the cardiovascular regenerative potential and increase the risk for cardiovascular disease. In this review, we summarize the rationale suggesting that Bartonella henselae could favour atherogenesis by infecting and damaging EPCs, thus reducing their vascular repair potential. These mechanisms suggest a novel link between communicable and non-communicable human diseases, and put forward the possibility that Bartonella henselae could enhance the susceptibility and worsen the prognosis in cardiovascular disease.

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Epidemiologic and Clinical Characteristics of Bartonella quintana and Bartonella henselae Endocarditis

Cited by 223 publications

References 51 publications

Bartonella quintanaandCoxiella burnetiias Causes of Endocarditis, India

Bartonella quintanaandCoxiella burnetiias Causes of Endocarditis, India

Factors associated with the rapid emergence of zoonotic Bartonella infections

Infections and cardiovascular disease: is Bartonella henselae contributing to this matter?

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