Epidemiologic and Clinical Analysis of Cervical Cancer Using Data from the Population-Based Osaka Cancer Registry

Yagi, Akira; Ueda, Yutaka; Kakuda, Mamoru; Tanaka, Yusuke; Ikeda, Sayaka; Matsuzaki, Shinya; Kobayashi, Eiji; Morishima, Toshitaka; Miyashiro, Isao; Fukui, Kiichi; Ito, Yuri; Nakayama, Tomio; Kimura, Tadashi

doi:10.1158/0008-5472.can-18-3109

Cited by 86 publications

(95 citation statements)

References 22 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Japan, the rate of age‐adjusted incidence of cervical cancer had been decreasing significantly in the 1980s and 1990s. However, the rate started to increase clearly after 2000 1 . Many cervical cancers are known to be caused by persistent infection with human papillomavirus (HPV), including HPV 16 and 18.…”

Section: Introductionmentioning

confidence: 99%

Corrected human papillomavirus vaccination rates for each birth fiscal year in Japan

et al. 2020

Self Cite

View full text Add to dashboard Cite

In Japan, the serious adverse events after human papillomavirus (HPV) vaccination were widely reported in the media. The Ministry of Health, Labour and Welfare of Japan (MHLW) announced the suspension of the governmental recommendation of HPV vaccine in 2013, and the inoculation rate has since sharply declined. The estimated inoculation rate for each birth fiscal year (FY) announced by the MHLW and the actual numbers for each birth FY surveyed by local governments were very different. In particular, the cumulative vaccination rate of girls born in FY2000 was regarded to be as high as 42.9% by the Council of the MHLW. However, this estimation included a confusion. When the suspension of the governmental recommendation was announced in FY2013, the girls born in FY2000 turned 13 years old, the targeted starting age of the HPV vaccination. The vaccination rate of this generation is considered to be quite low. The numbers were recalculated in this study. This study revealed that the real vaccination rate is only 14.3%. Female individuals born in or after FY2000 have been confirmed to be exposed to the same cervical cancer risk as before the HPV vaccine was introduced in Japan.

show abstract

Section: Introductionmentioning

confidence: 99%

Corrected human papillomavirus vaccination rates for each birth fiscal year in Japan

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, the high ratio (23,000/11,000 cases) for newly diagnosed patients with CIS and invasive cervical cancer may also reflect the failure of cervical cancer prevention in Japan [ 2 ]. Indeed, a few recent studies have highlighted an increase in the incidence of cervical cancer during the last two decades in this country, contradicting the current global trend [ 7 , 8 , 9 ]. For instance, a significant average annual percent change (AAPC) of 1.2% (95% confidence interval (CI): 0.2–2.2) was observed in the incidence of invasive cervical cancer from 1991 to 2010 [ 7 ], and a substantial increase (AAPC 17.9%, 95% CI: 10.5–25.8) was also observed in the incidence of CIS from 2006 to 2012 [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Increasing Incidence of Early-Stage Cervical Cancers of the Squamous Cell Carcinoma Subtype among Young Women

Noguchi

Zaitsu

Oki

et al. 2020

IJERPH

View full text Add to dashboard Cite

Few studies have reported on the increase in cervical cancer incidence in Japan. We aimed to determine the relevant trends in the metropolitan regions of Japan and to identify the population with the highest risk, based on histological subtype, cancer stage, and diagnostic processes. Using population-based data (2009–2013), we identified 2110 women, aged ≥20 years, with cervical cancer. We estimated the age-standardized and age-specific incidence rates of cervical cancer for the study period based on the 1985 national model population. The average annual percent change (AAPC) and 95% confidence interval (CI) were calculated using the joinpoint regression analysis. We stratified the analyses based on histological subtypes, stage, and diagnostic process via cancer screening. The increase in the overall age-standardized incidence was not significant. However, the increase was significant for women aged 30–39 years (AAPC 20.0%/year, 95% CI: 9.9–31.1), which was attributable to the increase in the incidence of the squamous cell carcinoma (SCC) subtype (AAPC 23.1%/year, 95% CI: 10.7–36.8). Among younger women, aged <50 years, further stratification showed an increase in the undiagnosed early-stage SCC subtype via cancer screening. In Japan, the incidence of HPV-related cervical cancer has been increasing in undiagnosed younger women.

show abstract

“…Changes in sexual lifestyle have been causing the spread of HPV infection in ever younger women, and the consistently low rates of HPV vaccination and cervical cancer screening in Japan have all contributed to the current dismal status. 1 In 2007, Australia became the first country to initiate a national HPV vaccination program; today both HPV vaccination and cervical cancer screening rates are extremely high there. It is projected that the annual incidence of cervical cancer in Australia will decrease to fewer than six new cases per 100,000 women by 2020, and to fewer than four cases per 100,000 women by 2028.…”

Section: Introductionmentioning

confidence: 99%

A survey of Japanese mothers on the effectiveness of the Ministry of Health, Labor and Welfare’s revised HPV vaccine leaflet

Shiomi

Ueda

Abe

et al. 2020

Human Vaccines & Immunotherapeutics

Self Cite

View full text Add to dashboard Cite

Introduction: In June of 2013, Japan's Ministry of Health, Labor and Welfare (MHLW) suspended its position of strong recommendation for the routine immunization of young girls against the Human Papilloma Virus (HPV) because of reports of adverse reactions after the vaccination. For the next four years, the MHLW's website warned about the significance of these adverse events. In January of 2018, MHLW's website was modified to reflect a less negative stance. We have studied public awareness of MHLW's revised leaflet in Japanese women whose daughters were of the targeted age for receiving the HPV vaccine and how this awareness influenced their intentions to get their daughters vaccinated. Materials and Methods: From June to December of 2018, a survey was conducted through the Departments of Obstetrics and Gynecology at 14 different medical facilities. The questionnaire was distributed to women whose daughters were of the HPV-vaccine-targeted age. The survey measured their responses before and after being presented with the 2018-revised MHLW leaflet. Responses from 384 mothers were analyzed. Results: Before being presented with the leaflet, the survey found that the percentage of responder's daughters already vaccinated was 6.5% (24/372). After reading the MHLW leaflet, an additional 6.9% (24/ 346) responded "I want to get my daughter vaccinated immediately", and 37.6% (130/346) responded "I have positive feelings about HPV vaccination". Discussion: By presenting the new MHLW leaflet at obstetrics and gynecology facilities, we expect to be able to effectively increase the HPV vaccination rate in Japan.

show abstract

Epidemiologic and Clinical Analysis of Cervical Cancer Using Data from the Population-Based Osaka Cancer Registry

Cited by 86 publications

References 22 publications

Corrected human papillomavirus vaccination rates for each birth fiscal year in Japan

Corrected human papillomavirus vaccination rates for each birth fiscal year in Japan

Recent Increasing Incidence of Early-Stage Cervical Cancers of the Squamous Cell Carcinoma Subtype among Young Women

A survey of Japanese mothers on the effectiveness of the Ministry of Health, Labor and Welfare’s revised HPV vaccine leaflet

Contact Info

Product

Resources

About